Results 41 to 50 of about 6,902 (250)

The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells [PDF]

, 2005
Deficiencies in Complex I have been observed in Parkinson's disease (PD) patients. Systemic exposure to rotenone, a Complex I inhibitor, has been shown to lead to selective dopaminergic cell death in vivo and toxicity in many in vitro models, including ...
Dukes, AA, Hastings, TG, Korwek, KM
core   +2 more sources

New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates

Scientia Pharmaceutica, 2017
According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics.
Liliana Azotla-Cruz, Irina V. Lijanova, Igor V. Ukrainets, Natalya V. Likhanova, Octavio Olivares-Xometl, Natalya L. Bereznyakova   +5 more
doaj   +1 more source

Meloxicam hydrochloride

IUCrData, 2023
The title salt, C14H14N3O4S2+·Cl− [systematic name: 2-(4-hydroxy-2-methyl-1,1-dioxo-1,2-benzothiazine-3-amido)-5-methyl-1,3-thiazol-3-ium chloride] is the hydrochloride derivative of meloxicam, a drug used to treat pain and inflammation in rheumatic ...
Fermin Flores Manuel, Martha Sosa Rivadeneyra, Sylvain Bernès   +2 more
doaj   +1 more source

Prompt Resolution of Hypoglycemia by Hepatic Transarterial Embolization for Malignant Insulinoma with Multiple Liver Metastases [PDF]

, 2014
A 45-year-old female who presented with loss of consciousness and a cold sweat was found to have a pancreatic tumor and multiple liver metastases. Laboratory studies showed marked hypoglycemia and inappropriately elevated serum insulin, C-peptide, and ...
Fujiwara, Hiroyasu, Harada, Ryo, Kanzaki, Hiromitsu, Kato, Hironari, Matsubara, Minoru, Muro, Shinichiro, Nakarai, Asuka, Nasu, Junichiro, Okada, Hiroyuki, Tanaka, Takehiro, Tsutsumi, Kouichiro, Uno, Masatoshi, Yamamoto, Kazuhide   +12 more
core   +1 more source

(Z)-2-(2-Chlorobenzylidene)-4-(prop-2-ynyl)-2H-1,4-benzothiazin-3(4H)-one

IUCrData, 2017
In the title compound, C18H12ClNOS, the thiazine-3-one ring of the 1,4-thiazin-3-one moiety adopts a slightly distorted twist-boat conformation. The dihedral angle between the benzene rings is 86.2 (1)°.
Nada Kheira Sebbar, Mohamed Ellouz, Younes Ouzidan, Manpreet Kaur, El Mokhtar Essassi, Jerry P. Jasinski   +5 more
doaj   +1 more source

2-[(2Z)-2-Benzylidene-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl]acetic acid

IUCrData, 2016
In the title compound, C17H13NO3S, the thiazine ring displays a screw-boat conformation. The dihedral angle between the terminal benzene ring and the mean plane of the 1,4-benzothiazine fused-ring system is 51.52 (6)°.
Nada Kheira Sebbar, Mohamed Ellouz, Joel T. Mague, Younes Ouzidan, El Mokhtar Essassi, Hafid Zouihri   +5 more
doaj   +1 more source

Crystal structure, Hirshfeld surface analysis and interaction energy, DFT and antibacterial activity studies of (Z)-4-hexyl-2-(4-methylbenzylidene)-2H-benzo[b][1,4]thiazin-3(4H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2020
The title compound, C22H25NOS, consists of methylbenzylidene and benzothiazine units linked to a hexyl moiety, where the thiazine ring adopts a screw-boat conformation.
Ghizlane Sebbar, Brahim Hni, Tuncer Hökelek, Joel T. Mague, Nada Kheira Sebbar, Bouchra Belkadi, El Mokhtar Essassi   +6 more
doaj   +1 more source

Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. [PDF]

, 2004
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by dopaminergic neuron-specific degeneration in the substantia nigra.
Asanuma, Masato, Diaz-Corrales, Francisco J, Miyazaki, Ikuko, Ogawa, Norio   +3 more
core   +1 more source

Study of Heterocyclic Ring Systems: Biopharmaceutical Applications of Substituted 4H-1,4-Benzothiazine and Piperazine

Journal of Physics: Conference Series, 2020
In present work study of biologically important heterocycles such as 4H-1,4-benzothzine and substituted piperazine was carried out. Reaction mixture of substituted 4H-1,4-Benzothiazine and piperazine was examined for their importance as biopharmaceutical
Sumit Saroha, Chhavi, P. Sharma
semanticscholar   +1 more source

Therapeutic paracetamol treatment in older persons induces dietary and metabolic modifications related to sulfur amino acids [PDF]

, 2011
Sulfur amino acids are determinant for the detoxification of paracetamol (N-acetyl-p-aminophenol) through sulfate and glutathione conjugations. Long-term paracetamol treatment is common in the elderly, despite a potential cysteine/glutathione deficiency.
Brandolini-Bunlon, Marion, Dardevet, Dominique, Dubray, Claude, Ducheix, Gilles, Glomot, Françoise, Lyan, Bernard, Papet, Isabelle, Pickering, Gisèle, Pujos-Guillot, Estelle   +8 more
core   +4 more sources