Results 51 to 60 of about 3,633 (196)

Cutaneous Photoaging: A Review of Melasma and Nanotechnological Approaches to Its Control

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Skin is a complex tissue that performs important functions to protect the body against environmental stressors and also synthesizes melanin, a pigment essential for preventing keratinocyte DNA from UV‐induced damage. Excessive solar radiation triggers skin photoaging, leading to hyperactivation of melanocytes and the development of melasma on the face.
Daniela Mayra de Oliveira Figueiredo, Mateus Freire Leite, Suraiya Saleem   +2 more
wiley   +1 more source

Crystal structures of 2-(4-nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one and 2-(2-nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one

Acta Crystallographica Section E: Crystallographic Communications, 2015
The crystal structures are reported of the isomeric compounds 2-(4-nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one, (I), and 2-(2-nitrophenyl)-3-phenyl-2,3-dihydro-4H-1,3-benzothiazin-4-one, (II), both C20H14N2O3S, being the para-nitro and ...
Hemant Yennawar, Aaron S. Cali, Yiwen Xie, Lee J. Silverberg   +3 more
doaj   +1 more source

2‐Phenyl‐1,2,6,7‐Tetrahydrocyclopenta[D][1,3]Thiazine‐4(5H)‐Thione: Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT Calculations, ADMET Prediction, and Molecular Docking†

Journal of Chemistry, Volume 2026, Issue 1, 2026.
The compound 2‐phenyl‐1,2,6,7‐tetrahydrocyclopenta[d][1,3]thiazine‐4(5H)‐thione (I) was synthesized from benzylideneaniline and 2‐amino‐1‐cyclopentene‐dithiocarboxylic acid. Its molecular structure was confirmed by FT‐IR and NMR spectroscopy, and the crystalline phase was verified by powder X‐ray diffraction.
Gerzon E. Delgado, Jonathan Cisterna, Carla Coy, Asiloé J. Mora, Marilia Guillen, Edward Ávila, Ricardo R. Contreras, Cecilia Chacón, Gustavo Marroquin, Gerson Márquez, Munmun Bardhan   +10 more
wiley   +1 more source

Ethyl 3-methyl-1-oxo-4H-1,4-benzothiazine-2-carboxylate monohydrate

IUCrData, 2018
The organic molecule in the title hydrate, C12H13NO3S·H2O, is folded across the S...N vector. Chains two molecules thick extending along the a-axis direction are formed by N—H...O and O—H...O hydrogen bonds.
Yamna Baryala, Youness El Bakri, El Hassane Anouar, Abdelfettahb Zerzouf, El Mokhtar Essassi, Joel T. Mague   +5 more
doaj   +1 more source

A Direct and an Efficient Regioselective Synthesis of 1,2-Benzothiazine 1,1-dioxides, β-Carbolinones, Indolo[2,3-c]pyran-1-ones, Indolo[3,2-c]pyran-1-ones, Thieno[2,3-c]pyran-7-ones and Pyrano[3’,4’:4,5]imidazo[1,2-a]pyridin-1-ones via Tandem Stille/Heterocyclization Reaction

Molecules, 2020
A general regioselective one-pot synthesis of 1,2-benzothiazine 1,1-dioxides from 2-iodo benzenesulfonamide moieties and allenylstannanes is described using a domino Stille-like/Azacyclization reaction. The conditions developed also opened a novel access
Badr Jismy, Khalil Cherry, Carine Maaliki, Samuel Inack Ngi, Mohamed Abarbri   +4 more
doaj   +1 more source

Trimeric aldolization product of 1,4-benzothiazine

, 1977
2H-1,4-Benzothiazine, the parent system of the mammalian phaeomelanic pigments, is a highly unstable molecule which readily undergoes a reversible aldolization to form, mainly, the cyclic trimer (5)
Prota G., NOVELLINO, ETTORE, Sodano G., Chioccara F.   +3 more
core   +1 more source

Evaluation of a New Riluzole‐Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH‐SY5Y‐ Derived Neurons

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The potential capability of a newly synthesized riluzole‐based compound, VA945, to affect neuronal excitability was tested by assessing its ability to modulate the biophysical properties of voltage‐gated sodium (Nav) and Delayed‐Rectifier Potassium (KDR) channels expressed in SH‐SY5Y human neuroblastoma cells differentiated into neurons.
J. Cazzola, F. Talpo, G. Faravelli, C. Donati, S. Maramai, M. Saletti, G. Giuliani, M. Paolino, A. Cappelli, M. Anzini, P. Sommi, A. Vitali, A. Sala, A. Trucco, G. R. Biella, P. Spaiardi   +15 more
wiley   +1 more source

Modellierung von Neuromelanin des Mittelhirns und Hirnstamms zur Charakterisierung der Metallbindung und des damit verbundenen MRT‐Kontrasts bei der Parkinson‐ und Alzheimer‐Krankheit

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Synthetische Neuromelanin‐Analoga werden verwendet, um die Bindung von Eisen und Kupfer an die Melaninkomponente oder an konjugiertes Protein (β‐Lactoglobulin) zu charakterisieren. Die Modelle bestätigen das Vorhandensein paramagnetischer mononuklearer Bindungsstellen und von Clustern aus aggregiertem Eisen oder gemischten Metalltypen, die jeweils die ...
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller   +11 more
wiley   +1 more source

(2Z)-2-(4-Chlorobenzylidene)-4-[2-(2-oxooxazoliden-3-yl)ethyl]-3,4-dihydro-2H-1,4-benzothiazin-3-one

IUCrData, 2017
In the title molecule, C20H17ClN2O3S, the oxazolidine ring is oriented towards the benzothiazine moiety so that the centroid of the former is ca 5.05 Å from the sulfur atom of the latter.
Mohamed Ellouz, Nada Kheira Sebbar, Mohammed Boulhaoua, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

1,4-Benzothiazine ATP-Sensitive Potassium Channel Openers: Modifications at the C‑2 and C‑6 Positions

, 2016
ATP-sensitive potassium (KATP) channels play a prominent role in controlling cardiovascular function. In this paper, a novel series of 4-(1-oxo-2-cyclopentenyl)-1,4-benzothiazine derivatives modified at the C-2, and C-6 positions were synthesized as ...
Violetta Cecchetti (1316763), Stefano Sabatini (1316760), Oriana Tabarrini (1316745), Paola Sabbatini (1947574), Michela Novelli (77048), Serena Massari (1600582), Vincenzo Calderone (1900531), Pellegrino Masiello (77056), Giuseppe Manfroni (1316766), Lara Testai (1900537), Alma Martelli (1900519), Maria Letizia Barreca (1941994)   +11 more
core   +1 more source