Results 71 to 80 of about 3,633 (196)

1,4-Benzothiazine ATP-Sensitive Potassium Channel Openers: Modifications at the C-2 and C-6 Positions

, 2013
ATP-sensitive potassium (KATP) channels play a prominent role in controlling cardiovascular function. In this paper, a novel series of 4-(1-oxo-2-cyclopentenyl)-1,4-benzothiazine derivatives modified at the C-2, and C-6 positions were synthesized as ...
Manfroni G, MARTELLI, ALMA, TESTAI, LARA, NOVELLI, MICHELA, Cecchetti V., CALDERONE, VINCENZO, Barreca ML, Sabbatini P, Sabatini S, Massari S, Tabarrini O, MASIELLO, PELLEGRINO   +11 more
core   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri   +6 more
wiley   +1 more source

Molecular docking and simulation of Zika virus NS3 helicase

BMC Chemistry, 2019
The Zika virus (ZIKV) has gained attention for the last few years due to the congenital microcephaly and Guillain–Barre Syndrome that resulted in humans. The non-structural protein-3 (NS3) helicase of ZIKV play an important role in viral RNA replication.
Syed Lal Badshah, Nasir Ahmad, Ashfaq Ur Rehman, Khalid Khan, Asad Ullah, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Yahia N. Mabkhot   +7 more
doaj   +1 more source

Methyl 4-Hydroxy-2,2-Dioxo-1H-2λ⁶,1-Benzothiazine-3-Carboxylate and Its Analogs Modified in the Benzene Moiety of the Molecule as New Analgesics

Scientia Pharmaceutica, 2020
In order to identify new regularities of the “structure−analgesic activity” relationship in the series of 2,1-benzothiazine derivatives, the synthesis of methyl 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate and a group ...
Igor V. Ukrainets, Lidiya A. Petrushova, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Tatiana V. Alekseeva, Inna I. Torianyk, Alexandra A. Davidenko   +6 more
doaj   +1 more source

Synthesis of Heterocyclic Skeletons by the Reaction of N1-(2-Cyanophenyl)-benzimidoyl Chloride with Thioamides

Molecules, 2002
The reaction of N-(2-cyanophenyl)benzimidoyl chloride with reagents containing a thioamide moiety, i.e. thioacetamide, benzylthiourea, symmetrical dialkyl- and diarylthioureas gave different cyclic products: 3,1-benzothiazine, 1,3,5-benzotriazocine and ...
Pavel Pazdera, Walid M. Fathalla
doaj   +1 more source

Pyrano[3,2-c][1,2] Benzothiazine 5,5-dioxide derivatives: Synthesis and Structural Assignment

, 1990
Pyrano[3,2-c][1,2] Benzothiazine 5,5-dioxide derivatives: Synthesis and NMR Structural ...
Dalla Croce P., La Rosa C., MOLINARI, Henriette   +2 more
core   +1 more source

Crystal structure of a 2:1 piroxicam–gentisic acid co-crystal featuring neutral and zwitterionic piroxicam molecules

Acta Crystallographica Section E: Crystallographic Communications, 2016
A new 2:1 co-crystal of piroxicam and gentisic acid [systematic name: 4-hydroxy-1,1-dioxo-N-(pyridin-2-yl)-2H-1λ6,2-benzothiazine-3-carboxamide–2-(4-oxido-1,1-dioxo-2H-1λ6,2-benzothiazine-3-amido)pyridin-1-ium–2,5-dihydroxybenzoic acid, 2C15H13N3O4S ...
Elizabeth M. Horstman, Jeffery A. Bertke, Toby J. Woods, Paul J. A. Kenis   +3 more
doaj   +1 more source

3,3,6-Tribromo-1-methyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide

Acta Crystallographica Section E, 2010
In the title compound, C9H6Br3NO3S, a halogenated benzothiazine derivative, the thiazine ring adopts a sofa conformation. The crystal studied was a racemic twin with a contribution of 72 (1)% of the major domain.
Ghulam Mustafa, Muhammad Nadeem Arshad, Islam Ullah Khan, Muhammad Shafiq   +3 more
doaj   +1 more source

Synthesis and reactivity of cyclic quinonimines of the 2H-1,4-benzothiazine series

, 1990
Periodate oxidn. of cysteinylhydroquinone Et ester gave 2H-1,4-benzothiazine, evidently via rearrangement of the intermediate quinonimine I (R = CO2Et). The relatively more stable quinonimine I (R = H) could be obtained in cryst. form by oxidn.
L. J. Wolfram, PROTA, GIUSEPPE, T. M. Schultz, CRESCENZI, ORLANDO   +3 more
core  

4-Hydroxyquinolones-2. 247*. 4-hydroxy-2-oxo- 1,2-dihydroquinoline or 4-hydroxy-2,2-dioxo- 1н-2λ6,1-benzothiazine [PDF]

, 2015
During the base-catalyzed heterocyclization of alkyl 2-[2-(alkoxycarbonyl)phenylsulfamoyl]acetates into the esters of 1-R-4-hydroxy-2,2-dioxo-1Н-2λ6,1-benzothiazine-3-carboxylic acids [2] it was observed that formation of 2,1-benzothiazine ring was ...
Petrushova, L. A., Davidenko, A. A., Grinevich, L. A., Ukrainets, I. V.   +3 more
core