Results 71 to 80 of about 6,902 (250)

The Pro-Oxidant Activity of Pheomelanin is Significantly Enhanced by UVA Irradiation: Benzothiazole Moieties Are More Reactive than Benzothiazine Moieties

International Journal of Molecular Sciences, 2018
It is generally considered that eumelanin (EM) is photoprotective while pheomelanin (PM) is phototoxic. A recent study using a mouse model demonstrated that PM produces reactive oxygen species (ROS) that cause DNA damage and eventually lead to ...
Hitomi Tanaka, Yui Yamashita, K. Umezawa, T. Hirobe, S. Ito, K. Wakamatsu   +5 more
semanticscholar   +1 more source

Evaluation of a New Riluzole‐Based Compound VA945 on Sodium and Potassium Conductances Expressed by SH‐SY5Y‐ Derived Neurons

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
The potential capability of a newly synthesized riluzole‐based compound, VA945, to affect neuronal excitability was tested by assessing its ability to modulate the biophysical properties of voltage‐gated sodium (Nav) and Delayed‐Rectifier Potassium (KDR) channels expressed in SH‐SY5Y human neuroblastoma cells differentiated into neurons.
J. Cazzola, F. Talpo, G. Faravelli, C. Donati, S. Maramai, M. Saletti, G. Giuliani, M. Paolino, A. Cappelli, M. Anzini, P. Sommi, A. Vitali, A. Sala, A. Trucco, G. R. Biella, P. Spaiardi   +15 more
wiley   +1 more source

Komplexchemie perhalogenierter Cyclopentadiene und Alkine [PDF]

, 1989
Die Darstellung und die Kristallstrukturen von (C5Cl4SPh)Rh-(1,5-COD)(2b), [C5Cl3(SR)2Mn](CO)3 [R = Ph (4a), Me (4b)] und [C5Cl2(SPh)3]Mn(CO)3 (5a) sowie die Darstellung von [C5Cl5-x (SBu)x]Mn(CO)3 [x = 1 (3b), 2 (4c), 3 (5b)], ferner Reaktionen von ...
Steiner, Doris, Sünkel, Karlheinz
core   +2 more sources

Modellierung von Neuromelanin des Mittelhirns und Hirnstamms zur Charakterisierung der Metallbindung und des damit verbundenen MRT‐Kontrasts bei der Parkinson‐ und Alzheimer‐Krankheit

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Synthetische Neuromelanin‐Analoga werden verwendet, um die Bindung von Eisen und Kupfer an die Melaninkomponente oder an konjugiertes Protein (β‐Lactoglobulin) zu charakterisieren. Die Modelle bestätigen das Vorhandensein paramagnetischer mononuklearer Bindungsstellen und von Clustern aus aggregiertem Eisen oder gemischten Metalltypen, die jeweils die ...
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller   +11 more
wiley   +1 more source

(2Z)-2-(4-Chlorobenzylidene)-4-[2-(2-oxooxazoliden-3-yl)ethyl]-3,4-dihydro-2H-1,4-benzothiazin-3-one

IUCrData, 2017
In the title molecule, C20H17ClN2O3S, the oxazolidine ring is oriented towards the benzothiazine moiety so that the centroid of the former is ca 5.05 Å from the sulfur atom of the latter.
Mohamed Ellouz, Nada Kheira Sebbar, Mohammed Boulhaoua, El Mokhtar Essassi, Joel T. Mague   +4 more
doaj   +1 more source

Ferrocenil-származékok, heterovegyületek, poli-, illetve makrociklusos és glükozid-származékaik szintézise, szerkezete, sztereokémiai, molekuladinamikai és szisztematikus spektroszkópiai vizsgálata = Synthesis, structure, molecular dynamic, stereochemical and systematic spectroscopic study of ferrocenyl derivatives, heterocycles and their poly- and macrocyclic derivatives and glycosides. [PDF]

, 2011
Több száz új, várhatóan biológiailag aktív ferrocén (Fc) származékot és heterociklusos vegyületet állítottunk elő. Szerkezetüket komplex nagyműszeres vizsgálatokkal (IR, 1H-, 13C-, 15N NMR, DNOE NMR, MS, X-ray) derítettük fel, a reakciómechanizmust ...
Csámpai, Antal, Sohár, Pál, Zsoldosné dr. Mády, Virág   +2 more
core  

Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
Synthetic neuromelanin analogs are used to characterize iron and copper binding to the melanin moiety or to conjugated protein (β‐lactoglobulin). The models confirm the presence of paramagnetic mononuclear‐binding sites and iron or mixed‐metal clusters that enhance water proton relaxation to varying degrees.
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller   +11 more
wiley   +1 more source

Crystal structure of (E)-2-benzylidene-4-[(3-phenyl-4,5-dihydroisoxazol-5-yl)methyl]-2H-benzo[b][1,4]thiazin-3(4H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C25H20N2O2S, the dihydroisoxazole ring exhibits an envelope conformation with the methine atom being the flap, while the 1,4-thiazine ring displays a screw-boat conformation.
Nada Kheira Sebbar, Mohamed Ellouz, El Mokhtar Essassi, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Eumelanin and pheomelanin are predominant pigments in bumblebee (Apidae: Bombus) pubescence [PDF]

, 2017
Background: Bumblebees (Hymenoptera: Apidae: Bombus) are well known for their important inter- and intra-specific variation in hair (or pubescence) color patterns, but the chemical nature of the pigments associated with these patterns is not fully ...
Alberto, Jorge, Ornosa Gallego, Concepción, Polidori, Carlo   +2 more
core   +2 more sources

Organic Electrochemical Transistors Monolithically Integrated with Precise Micro‐Dispensing Enable High‐Performance Biosignals Amplification

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This research showcases a micro‐dispensing strategy for integrating high‐performance organic electrochemical transistors (OECTs) and amplifiers onto flexible substrates. The method achieves precise material deposition, enabling fully micro‐dispensed OECT amplifiers with a record 1 MHz gain‐bandwidth product.
Roberto Granelli, Virginia M. Demartis, Giulia Frusconi, Zsolt M. Kovács‐Vajna, Fabrizio Torricelli   +4 more
wiley   +1 more source