Results 91 to 100 of about 6,902 (250)

Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials [PDF]

, 2012
A series of cinnamic acid/4-aminoquinoline conjugates conceived to link, through a proper retro-enantio dipeptide, a heterocyclic core known to prevent hemozoin formation, to a trans-cinnamic acid motif capable of inhibiting enzyme catalytic Cys residues,
Bianca C Perez, Cada Teixeira, Jiri Gut, Jose R B Gomes, Marta Figueiras, Paula Gomes, Philip J Rosenthal   +6 more
core   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri   +6 more
wiley   +1 more source

Preparation of Microcrystals of Piroxicam Monohydrate by Antisolvent Precipitation via Microfabricated Metallic Membranes with Ordered Pore Arrays [PDF]

, 2017
Microcrystals of piroxicam (PRX) monohydrate with a narrow size distribution were prepared from acetone/PRX solutions by antisolvent crystallization via metallic membranes with ordered pore arrays.
Davey R., Elena Simone, Fessi H., Goran T. Vladisavljević, Joshi J. T., Kini A. G., Kurup M., Löbenberg R., Nighute A. B., Rahimah Othman, Richard G. Holdich, Zoltan K. Nagy   +11 more
core   +2 more sources

Tautomeric Equilibria Studies by Mass Spectrometry [PDF]

, 2008
Tautomerism in organic chemistry has been extensively studied in condensed phase by spectrometric methods, mainly by IR and NMR techniques. Mass spectrometry studies start 40 years ago but just recently it has been recognized the importance of the mass ...
Eduardo A. Castro, Jorge J. Furlong, Mercedes M. Schiavonni, Patricia E. Allegretti   +3 more
core   +1 more source

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions [PDF]

, 2016
This work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process.
Adebisi, Adeola O., Al-Hamidi, Hiba, Asare-Addo, Kofi, Conway, Barbara R., Hussain, Tariq, Kaialy, Waseem, Nokhodchi, Ali   +6 more
core   +2 more sources

Novel (Hetero)arylalkenyl propargylamine compounds are protective in toxin-induced models of Parkinson's disease [PDF]

, 2016
Background: Mitochondrial dysfunction, oxidative stress and their interplay are core pathological features of Parkinson's disease. In dopaminergic neurons, monoamines and their metabolites provide an additional source of reactive free radicals during ...
Baranyi, M, Chai, C.l.l., Dunkel, P, FRAU, LUCIA, Goloncser, F, Huleatt, P.b., Khoo, Ml, Kittel, A, Kulcsar, S, Matyus, P, MORELLI, MICAELA, Otrokocsi, L, PINNA, ANNALISA, PORCEDDU, PIER FRANCESCA, Sperlagh, B.   +14 more
core   +1 more source

Prospective Isolation According to Melanin Pigment Content of Melanoma Cells With Heterogeneous Potentials for Disease Propagation

Pigment Cell &Melanoma Research, Volume 38, Issue 4, July 2025.
ABSTRACT Intra‐tumoral heterogeneity poses a major challenge to treating and managing cancer patients. A characteristic feature of melanoma is its composition of cancer cells with typically heterogeneous content of melanin pigment, the production of which is a hallmark of normal melanocytic differentiation but of poorly understood consequence in ...
Clare Fedele, Gamze Kuser‐Abali, Ralph Rossi, Peinan Zhao, Jason Li, Malaka Ameratunga, Pacman Szeto, YouFang Zhang, Miles Andrews, Mark Shackleton   +9 more
wiley   +1 more source

Bio- és gyógyszermolekulák mikrospeciációja = Microspeciation of bio- and drug molecules [PDF]

, 2013
A kutatás csoportosított eredményei az alábbiak: 1) Új elvek és módszerek bio- és gyógyszermolekulák mikrospeciációjában 1)a) A mikroszkópikus lipofilitás meghatározása, különös tekintettel az ikerionos és töltésmentes protonáltsági izomerekre A ...
Béni, Szabolcs, Hosztafi, Sándor, Kovács, Zsuzsanna, Mazák, Károly, Mazákné Kraszni, Márta, Noszál, Béla   +5 more
core  

1-Propyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide

Acta Crystallographica Section E, 2010
In the title compound, C11H13NO3S, a benzothiazine derivative, the heterocycle adopts a sofa conformation. In the crystal, weak C—H...O hydrogen bonds connect the molecules into a three-dimensional network.
Islam Ullah Khan, Muhammad Shafiq, Muhammad Nadeem Arshad   +2 more
doaj   +1 more source

The Pomegranate Flower Water Extract Negatively Regulates Melanogenesis by Suppressing MITF Expression and Its Target Enzymes

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background The aesthetic issues caused by pigmentation are increasing people's demand for skin whitening. Considering its long‐term use, it is very important for searching safe and effective agents. Pomegranate flower, a kind of traditional Chinese medicine, has shown promising anti‐inflammatory, antioxidant, and antidiabetic properties, but ...
Peng Shu, Nannan Xu, Nuermaimaiti Abudukelimu, Parida Aiziti, Deng Zang, Jiangyu Zhao, Yuan Wang   +6 more
wiley   +1 more source