Results 61 to 70 of about 3,633 (196)

Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
Synthetic neuromelanin analogs are used to characterize iron and copper binding to the melanin moiety or to conjugated protein (β‐lactoglobulin). The models confirm the presence of paramagnetic mononuclear‐binding sites and iron or mixed‐metal clusters that enhance water proton relaxation to varying degrees.
Niklas Wallstein, Andrea Capucciati, Andreas Pöppl, Claudia S. Schnohr, Michela Sturini, André Pampel, Carsten Jäger, Luigi Zecca, Fabio A. Zucca, Enrico Monzani, Luigi Casella, Harald E. Möller   +11 more
wiley   +1 more source

Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent

Drug Design, Development and Therapy, 2022
Fatima Rashid,1 Matloob Ahmad,2 Usman Ali Ashfaq,1 Aamal A Al-Mutairi,3 Sami A Al-Hussain3 1Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan; 2Department of Chemistry, Government College University ...
Rashid F, Ahmad M, Ashfaq UA, Al-Mutairi AA, Al-Hussain SA   +4 more
doaj  

Crystal structure of (E)-2-benzylidene-4-[(3-phenyl-4,5-dihydroisoxazol-5-yl)methyl]-2H-benzo[b][1,4]thiazin-3(4H)-one

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C25H20N2O2S, the dihydroisoxazole ring exhibits an envelope conformation with the methine atom being the flap, while the 1,4-thiazine ring displays a screw-boat conformation.
Nada Kheira Sebbar, Mohamed Ellouz, El Mokhtar Essassi, Mohamed Saadi, Lahcen El Ammari   +4 more
doaj   +1 more source

Synthesis and antimalarial activity of pyrazolo and pyrimido benzothiazine dioxide derivatives

, 2011
A series of phenylsubstituted pyrazolo and pyrimido benzothiazine dioxide derivatives were synthesized and investigated for their abilities to inhibit b-hematin formation, hemoglobin hydrolysis and in vivo for their antimalarial efficacy in rodent ...
Álvarez-Larena, Ángel, Lobo, Gricela, Barazarte, Arthur, Gamboa, Neira, Charris, Jaime E., Rodrigues, Juan R., López, Simón E., Capparelli, Mario V.   +7 more
core   +1 more source

Organic Electrochemical Transistors Monolithically Integrated with Precise Micro‐Dispensing Enable High‐Performance Biosignals Amplification

Advanced Science, Volume 12, Issue 40, October 27, 2025.
This research showcases a micro‐dispensing strategy for integrating high‐performance organic electrochemical transistors (OECTs) and amplifiers onto flexible substrates. The method achieves precise material deposition, enabling fully micro‐dispensed OECT amplifiers with a record 1 MHz gain‐bandwidth product.
Roberto Granelli, Virginia M. Demartis, Giulia Frusconi, Zsolt M. Kovács‐Vajna, Fabrizio Torricelli   +4 more
wiley   +1 more source

Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2018
The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have ...
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, Galina Sim   +8 more
doaj   +1 more source

1,2-Benzothiazine 1,1-Dioxide P₂−P₃ Peptide Mimetic Aldehyde Calpain I Inhibitors

, 2016
A series of peptide mimetic aldehyde inhibitors of calpain I was prepared in which the P2 and P3 amino acids were replaced by substituted 3,4-dihydro-1,2-benzothiazine-3-carboxylate 1,1-dioxides.
Ron Bihovsky (3012705), Ming Tao (490392), Gregory J. Wells (2125456), Kurt A. Josef (2417461)   +3 more
core   +1 more source

Synthesis of Anthraquinone Mono‐ and Diboron Complexes with Near‐Infrared Panchromatic Absorption

Chemistry – A European Journal, Volume 31, Issue 53, September 19, 2025.
Anthraquinone boron complexes bearing β‐iminoenolate ligand(s) exhibit strongly substituent‐dependent absorption properties. Unsubstituted monoboron and diboron complexes show sharp UV–Vis–NIR absorption spectra resulting from increased molecular rigidity induced by boron coordination.
Yasuhiro Kubota, Ayumi Ogasawara, Shota Mizuno, Toshiyasu Inuzuka, Kazumasa Funabiki   +4 more
wiley   +1 more source

Solid‐Phase Synthesis of 1,3,5,6‐Tetra‐Substituted 3,5‐Dihydroimidazo[4,5‐c][1,2]Thiazin‐4(1 H)‐One 2,2‐Dioxide Derivatives

Journal of Heterocyclic Chemistry, Volume 62, Issue 9, Page 938-943, September 2025.
Through an efficient solid‐phase synthesis method, 32 different 1,3,5,6‐tetra‐substituted 3,5‐dihydroimidazo[4,5‐c][1,2]thiazin‐4(1H)‐one 2,2‐dioxide derivatives were synthesized. The derivative library, with a total of four diversities, showed an overall yield of 7%–32% over 8 steps.
Jimin Moon, Hyojin Lee, Sohee Kim, Taeho Lee   +3 more
wiley   +1 more source

1-Propyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide

Acta Crystallographica Section E, 2010
In the title compound, C11H13NO3S, a benzothiazine derivative, the heterocycle adopts a sofa conformation. In the crystal, weak C—H...O hydrogen bonds connect the molecules into a three-dimensional network.
Islam Ullah Khan, Muhammad Shafiq, Muhammad Nadeem Arshad   +2 more
doaj   +1 more source