Results 21 to 30 of about 6,902 (250)

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors

Molecules, 2022
Alzheimer’s disease (AD) is a slowly progressive neurodegenerative disease that causes dementia in people aged 65 and over. In the present study, a series of thiadiazole hybrid compounds with benzothiazine derivatives as acetylcholinesterase inhibitors ...
Sazan Haji Ali, Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Zafer Asım Kaplancıklı   +5 more
doaj   +1 more source

Bioinspired Heterocyclic Partnership in a Cyanine-Type Acidichromic Chromophore

Molecules, 2020
A new red hair-inspired 1,4-benzothiazine-based scaffold is disclosed herein, built upon a modular D-π-A architecture via condensation of the easily accessible 3-phenyl-2H-1,4-benzothiazine with indole-3-carboxaldehyde.
Maria Laura Alfieri, Lucia Panzella, Marco d’Ischia, Alessandra Napolitano   +3 more
doaj   +1 more source

Exploring the therapeutic potential of benzothiazine-pyrazole hybrid molecules against alpha-glucosidase: Pharmacological and molecular modelling based approach

Saudi Journal of Biological Sciences, 2021
Diabetes mellitus (DM) is a metabolic disorder and a significant health problem all over the world. The current study elucidates the inhibitory potentials of the benzothiazine-pyrazole hybrid series against the α-Glucosidase enzyme. The molecular docking
Saman Taj, Matloob Ahmad, Abdulrahman Alshammari, A. Alghamdi, Usman Ali Ashfaq   +4 more
semanticscholar   +1 more source

Sulfoximines-Assisted Rh(III)-Catalyzed C–H Activation and Intramolecular Annulation for the Synthesis of Fused Isochromeno-1,2-Benzothiazines Scaffolds under Room Temperature

Molecules, 2020
A mild and facile Cp*Rh(III)-catalyzed C–H activation and intramolecular cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines scaffolds using S-phenylsulfoximides and 4-diazoisochroman-3-imine as
Bao Wang, Xu Han, Jian Li, Chunpu Li, Hong Liu   +4 more
doaj   +1 more source

Novel applications of the "t-amino effect" in heterocyclic chemistry. Synthesis of a pyrrolo[1,2-a]quinazoline and 5H-pyrrolo[1,2-a][3,1]benzothiazines [PDF]

, 1984
1-(1-Pyrrolidinyl)benzenes substituted with an imino- or an in situ generated thiocarbonyl group in the 2-position rearrange upon heating to quinazoline and benzothiazine derivatives ...
Hamzink, M.R.J., Reinhoudt, D.N., Verboom, W., Visser, R.   +3 more
core   +3 more sources

On the application of knoevenagel condensation for the synthesis of benzylidene benzothiazine compounds and structural study

Química Nova, 2006
The synthesis and physico-chemical properties of new 6-acetylamino or 6-benzoyl-amino 2-benzylidene-4-methyl-4H-benzo[1,4]thiazin-3-ones and 6-benzoylamino or 6-nitro 2-benzylidene-4H-benzo[1,4]thiazin-3-ones are described.
Ana Maria Alves de Souza, Vera Lucia de Miranda Guarda, Lúcia Fernanda Cavalcanti da Costa Leite, José Maria Barbosa Filho, Maria do Carmo Alves de Lima, Suely Lins Galdino, Ivan da Rocha Pitta   +6 more
doaj   +3 more sources

Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives [PDF]

, 2016
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).A number of 1,2 ...
Ann Hunter, Bariş, Buwa, Chandani Patel, Chikhalia, Jatinder Bassin, Jenna Flye, Lee Martin, Madhu Goyal, Maheshwari, Mark Scott, Martinez, Rathod   +12 more
core   +2 more sources

Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2019
According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2&
Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, Galina Sim   +8 more
doaj   +1 more source

Cutaneous Malignant Melanoma Incidences Analyzed Worldwide by Sex, Age, and Skin Type over Personal Ultraviolet-B Dose Shows No Role for Sunburn but Implies One for Vitamin D\u3csub\u3e3\u3c/sub\u3e [PDF]

, 2016
Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290–400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to ...
Godar, Dianne E., Merrill, Stephen, Subramanian, Madhan   +2 more
core   +2 more sources

Synthesis and bioassay of azolyl benzothiazine carboxamides [PDF]

AIP Conference Proceedings, 2020
Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti- inflammatory drugs (NSAIDs) available in the market.
Siva Sankar, P., Sravya, G., Rajeswari, T., Padmavathi, V.   +3 more
openaire   +3 more sources