Results 21 to 30 of about 3,633 (196)
Derivatives of benzo-1,4-thiazine-3-carboxylic acid and the corresponding amino acid conjugates
Beilstein Journal of Organic Chemistry, 2022 Herein, we present the synthesis and utilization of derivatives of 4H-benzo[b][1,4]thiazine-3-carboxylic acid. These benzothiazine compounds were assembled via the coupling of aminothiols and bromopyruvates.
Péter Kisszékelyi +4 more
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Microglial dynamics and ferroptosis induction in human iPSC-derived neuron-astrocyte-microglia tri-cultures. [PDF]
FEBS Open BioA tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Li HL +6 more
europepmc +2 more sources
Molecules, 2020 A mild and facile Cp*Rh(III)-catalyzed C–H activation and intramolecular cascade annulation protocol has been proposed for the furnishing of highly fused isochromeno-1,2-benzothiazines scaffolds using S-phenylsulfoximides and 4-diazoisochroman-3-imine as
Bao Wang +4 more
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Synthesis of quinazolino‐1,3‐benzothiazine derivatives [PDF]
Journal of Heterocyclic Chemistry, 1992 AbstractThe ring‐closure reactions of N‐(3,4‐dimethoxyphenylthiomethyl)‐2‐nitrobenzamide derivatives 5a,b with phosphoryl chloride gave 4‐(2‐nitrophenyl)‐2H1,3‐benzothiazine derivatives 7a,b, which on reduction yielded 4‐(2′‐aminophenyl)‐3,4‐dihydro‐2H‐1,3‐benzothiazines 8a,b.
Szabó János +5 more
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Benzothiazines in Synthesis. A Total Synthesis of Pseudopteroxazole. [PDF]
ChemInform, 2005 An enantioselective total synthesis of the naturally occurring antitubercular agent pseudopteroxazole is described. The synthesis is organized around the use of a stereoselective, intramolecular addition of a sulfoximine carbanion to an alpha,beta-unsaturated ester to form an enantiomerically pure benzothiazine.
Michael, Harmata, Xuechuan, Hong
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IUCrData, 2023 The title salt, C14H14N3O4S2+·Cl− [systematic name: 2-(4-hydroxy-2-methyl-1,1-dioxo-1,2-benzothiazine-3-amido)-5-methyl-1,3-thiazol-3-ium chloride] is the hydrochloride derivative of meloxicam, a drug used to treat pain and inflammation in rheumatic ...
Fermin Flores Manuel +2 more
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Synthesis and bioassay of azolyl benzothiazine carboxamides [PDF]
AIP Conference Proceedings, 2020 Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti- inflammatory drugs (NSAIDs) available in the market.
Siva Sankar, P. +3 more
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Acta Crystallographica Section E: Crystallographic Communications, 2020 In the title molecule, C12H13N3O2S, the benzothiazine moiety is slightly non-planar, with the imidazolidine portion twisted only a few degrees out of the mean plane of the former.
Mohamed Srhir +6 more
doaj +1 more source
rac-2,3-Diphenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-one 1-oxide
IUCrData, 2017 In the title compound, C19H14N2O2S, the thiazine ring exhibits a screw-boat pucker. The oxygen atom on the sulfur atom of the ring is pseudo-axial on the thiazine ring.
Hemant P. Yennawar +3 more
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(Z)-2-(2-Chlorobenzylidene)-4-(prop-2-ynyl)-2H-1,4-benzothiazin-3(4H)-one
IUCrData, 2017 In the title compound, C18H12ClNOS, the thiazine-3-one ring of the 1,4-thiazin-3-one moiety adopts a slightly distorted twist-boat conformation. The dihedral angle between the benzene rings is 86.2 (1)°.
Nada Kheira Sebbar +5 more
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