Results 11 to 20 of about 6,902 (250)

Efficient synthesis of benzothiazine and acrylamide compounds [PDF]

Química Nova, 2010
This article describes the synthesis of the new (2Z)-2-(4-methoxybenzylidene)-6-nitro-4H -benzo[1,4]thiazin-3-one, (2Z)-2-(4-methoxybenzylidene)-4-methyl-6-nitro-4H-benzo[1,4]thiazin-3-one, (2Z)-6-amino-2-(4-methoxybenzylidene)-4H -benzo[1,4]thiazin-3 ...
Ana Maria Alves Souza, Simone Torres Pádua Walfrido, Lúcia Fernanda Costa Leite, Maria Carmo Alves Lima, Suely Lins Galdino, Ivan Rocha Pitta, José Maria Barbosa Filho, Carlos Alberto De Simone, Javier Alcides Ellena   +8 more
doaj   +4 more sources

Design, synthesis, and evaluation of 1,4-benzothiazine-3-one containing bisamide derivatives as dual inhibitors of Staphylococcus aureus with plausible application in a urinary catheter [PDF]

Frontiers in Chemistry
In this study, 1,4-benzothiazine-based bisamide derivatives, a new class of antibacterial agents targeting bacterial peptide deformylase (PDF), were designed and synthesized to combat Staphylococcus aureus infection.
Kaushal Naithani, Arka Das, Mamta Ushare, Subham Nath, Subham Nath, Rashmita Biswas, Rashmita Biswas, Anirban Kundu, Kazi Tawsif Ahmed, Utpal Mohan, Utpal Mohan, Subhendu Bhowmik   +11 more
doaj   +2 more sources

Design, Synthesis and Pharmacological Evaluation of 2-(3-BenzoyI-4-Hydroxy-1,1-Dioxido-2H-Benzo[e][1,2]thiazin-2-yI)-N-(2-Bromophenyl) Acetamide as Antidiabetic Agent [PDF]

Drug Design, Development and Therapy, 2022
Fatima Rashid,1 Matloob Ahmad,2 Usman Ali Ashfaq,1 Aamal A Al-Mutairi,3 Sami A Al-Hussain3 1Department of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan; 2Department of Chemistry, Government College University ...
Rashid F, Ahmad M, Ashfaq UA, Al-Mutairi AA, Al-Hussain SA   +4 more
doaj   +2 more sources

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides [PDF]

Beilstein Journal of Organic Chemistry
The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation.
Ayesha Saeed, Shahana Ehsan, Muhammad Zia-ur-Rehman, Erin M. Marshall, Sandra Loesgen, Abdus Saleem, Simone Giovannuzzi, Claudiu T. Supuran   +7 more
doaj   +2 more sources

Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms

Scientia Pharmaceutica, 2018
Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in ...
Igor V. Ukrainets, Anna A. Burian, Vyacheslav N. Baumer, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Igor A. Tugaibei, Natali I. Voloshchuk, Pavlo S. Bondarenko   +7 more
doaj   +2 more sources

The involvement of the trisulfur radical anion in electron-catalyzed sulfur insertion reactions: facile synthesis of benzothiazine derivatives under transition metal-free conditions

Chemical Science, 2016
An efficient and practical synthesis of benzothiazine by K2S initiated sulfur insertion reaction with enaminones via electron catalysis is developed.
Shun-Yi Wang, Shun-Jun Ji
exaly   +2 more sources

Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2018
The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have ...
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, Galina Sim   +8 more
doaj   +2 more sources

NorA Efflux Pump Inhibitors: Expanding SAR Knowledge of Pyrazolo[4,3-c][1,2]benzothiazine 5,5-Dioxide Derivatives. [PDF]

Arch Pharm (Weinheim)
The pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐dioxide class was investigated with the aim of enlarging the array of Staphylococcus aureus NorA efflux pump inhibitors. The ethidium bromide efflux assay was used as a first indication of NorA inhibition; then, the ability of compounds to synergize with ciprofloxacin (CPX) against both wild‐type and resistant ...
Cernicchi G, Di Gregorio A, Felicetti T, Rampacci E, Casari G, Armeni T, Romaldi B, Zefaj E, Passamonti F, Massari S, Manfroni G, Barreca ML, Tabarrini O, Vignaroli C, Sabatini S.   +14 more
europepmc   +2 more sources

3-Benzoyl-2-hydroxy-3a-[(3-methylquinoxalin-2-yl)methyl]-1H-pyrrolo[2,1-c][1,4]benzothiazine-1,4(3aH)-dione

Molbank, 2023
The reaction of 3-benzoylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-trione with 2,3-dimethylquinoxaline afforded 3-benzoyl-2-hydroxy-3a-[(3-methylquinoxalin-2-yl)methyl]-1H-pyrrolo[2,1-c][1,4]benzothiazine-1,4(3aH)-dione in a moderate yield. The compound was
Ekaterina A. Lystsova, Ekaterina E. Khramtsova   +1 more
doaj   +1 more source

Enantioselective Synthesis of 1,2-Benzothiazine 1-Imines via RuII/Chiral Carboxylic Acid-Catalyzed C-H Alkylation/Cyclization.

Angewandte Chemie, 2023
Sulfondiimines are diaza-analogues of sulfones with a chiral sulfur center. Compared to sulfones and sulfoximines, their synthesis and transformations have so far been studied to a lesser extent.
Long Huang, Yuta Kitakawa, Kodai Yamada, Futa Kamiyama, M. Kojima, Tatsuhiko Yoshino, Shigeki Matsunaga   +6 more
semanticscholar   +1 more source