Results 51 to 60 of about 4,651 (214)

Design, evaluation, cytotoxic activity, molecular docking, ADMET analysis, and dynamic simulations and the preparation of new isoxazoles, thiazoles, 1,3-thiazines, and thiazolopyrimidines derived from quinoline-pyridopyrimidines

Pharmaceutical Biology
Context Quinoline, isoxazole, and pyridothiazolopyrimidinone derivatives are novel compounds with significant biological activity, exhibiting anticancer properties and holding promising therapeutic applications.Objective This investigation synthesized ...
Ameen A. Abu-Hashem, Nasser Amri, Ahmed F. El-Sayed   +2 more
doaj   +1 more source

2-[(2Z)-2-Benzylidene-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl]acetic acid

IUCrData, 2016
In the title compound, C17H13NO3S, the thiazine ring displays a screw-boat conformation. The dihedral angle between the terminal benzene ring and the mean plane of the 1,4-benzothiazine fused-ring system is 51.52 (6)°.
Nada Kheira Sebbar, Mohamed Ellouz, Joel T. Mague, Younes Ouzidan, El Mokhtar Essassi, Hafid Zouihri   +5 more
doaj   +1 more source

Synthesis, Characterization, In Vitro and In Silico Investigation of Azo‐Based Co(III), Zn(II), and Pd(II) Complexes Against Human Leukemia

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
A novel azo ligand (IDB) and its Co(III), Zn(II), and Pd(II) complexes were synthesized and characterized. The Pd(II) complex demonstrated potent activity against HL‐60 leukemia cells, modulated oxidative stress markers (MDA, CAT), and showed strong binding affinity (−6.6367 kcal/mol) to the Aurora kinase enzyme in molecular docking studies.
Yareeb J. Sahar, Abbas F. Yasir, Hussein A. K. Kyhoiesh   +2 more
wiley   +1 more source

2-(3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl)acetohydrazide

Acta Crystallographica Section E, 2010
In the title compound, C10H11N3O2S, the thiazine ring exists in a conformation intermediate between twist-boat and half-chair. The dihedral angle between the mean plane of the thiazine ring and the hydrazide group is 89.45 (13)°.
Azher Saeed, Zaid Mahmood, Shiyao Yang, Saeed Ahmad, Muhammad Salim   +4 more
doaj   +1 more source

Stereoselective Construction of Benzo‐Fused Tetrahydropyrrole Thiazines From Saccharin

European Journal of Organic Chemistry, Volume 29, Issue 33, 1 September 2026.
Saccharin was used as a template to construct a series of 10a‐substituted, benzo‐fused, pyrrolo thiazinone dioxides. Thereafter, diastereo‐divergent 10‐keto reduction gave either diastereomeric alcohol in a process that did not rely on the substituent at 10a's identity.
Seanán Doyle, Matthew Kiernan, Jordan Smyth, Ajay Mathew, Conor J. Crawford, Julia Bruno‐Colmenarez, Patrick J. Guiry, Aisha Khalifa, Paul Evans   +8 more
wiley   +1 more source

Synthesis of a 6‑CF₃‑Substituted 2‑Amino-dihydro-1,3-thiazine β‑Secretase Inhibitor by N,N‑Diethylaminosulfur Trifluoride-Mediated Chemoselective Cyclization

, 2018
The synthesis of a 6-CF3-substituted 2-amino-dihydro-1,3-thiazine via N,N-diethylaminosulfur trifluoride (DAST)-mediated cyclization of N-hydroxypropyl thiourea 6 is described.
Masayoshi Ogawa, Masayoshi Ogawa (2023135), Shinji Suzuki, Shinya Hisakawa (2532121), Takuya Oguma, Kosuke Anan, Ken-ichi Kusakabe, Ken-ichi Kusakabe (1648057), Kosuke Anan (2673073), Akihiro Takada (5904227), Shinji Suzuki (2277829), Takuya Oguma (2013787), Shinya Hisakawa, Akihiro Takada   +13 more
core   +2 more sources

(Z)-(1,3-Thiazinan-2-ylideneamino)formonitrile

Acta Crystallographica Section E, 2009
In the title molecule, C5H7N3S, the thiazine ring shows a conformation close to a half-boat. The Cremer & Pople puckering parameters of the thiazine ring are q2 = 0.4645 (2) Å, θ = 132.4 (3) and ...
Yu-wen Peng, Lin-hai Wu
doaj   +1 more source

A Hierarchical Framework for In Vitro Models of Alzheimer's Disease

WIREs Mechanisms of Disease, Volume 18, Issue 5, September/October 2026.
There is no “best” in vitro model of Alzheimer's disease. Instead, different experimental platforms address different biological questions, and their combined use may improve mechanistic understanding and translational success. ABSTRACT Alzheimer's disease (AD) remains a major global health challenge, with a high rate of clinical trial failures often ...
Florencia B. Balverde‐Caballero, Jordi Pérez‐Tur, Fernando Cardona   +2 more
wiley   +1 more source

2-(3-Oxo-3,4-dihydro-2H-1,4-benzothiazin-4-yl)acetamide

Acta Crystallographica Section E, 2010
In the title compound, C10H10N2O2S, the thiazine ring approximates to an envelope form with the S atom in the flap position. The amide group attached to the acetate group is almost perpendicular to the mean plane of the thiazine ring [dihedral angle = 88.
Muhammad Salim, Shiyao Yang, Zaid Mahmood, Azher Saeed, Muhammad Saleem Akhtar   +4 more
doaj   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source