Results 101 to 110 of about 24,637 (218)

In Silico Evaluation of 5‐Arylidine Glitazone Esters as Potential Antidiabetic Agents: ADMET, Molecular Docking, Dynamics, MMGBSA and DFT Studies

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
This study presents an in silico evaluation of 5‐Arylidine Glitazone Esters 3ai‐ev as Potential Antidiabetic Agents utilizing ADMET, Molecular Docking, Dynamics, MMGBSA, and DFT Studies. The drug‐like characteristics, safety, binding affinity, stability, free binding energy, and electronic properties of 31 compounds were investigated.
Kabelo P. Mokgopa, Mofeli B. Leoma, Tendamudzimu Tshiwawa, Ndivhuwo R. Tshiluka   +3 more
wiley   +1 more source

Correspondence to editorial on “Comparison of glucagon-like peptide-1 receptor agonists and thiazolidinediones on treating nonalcoholic fatty liver disease: a network meta-analysis” [PDF]

Clinical and Molecular Hepatology
Hayeon Kim, Min Jeong Park, Myeong Gyu Kim, Kyungim Kim   +3 more
doaj   +1 more source

GLP‐1 Receptor Agonists in Metabolic Dysfunction‐Associated Steatotic Liver Disease: Bridging Hepatic and Cardiovascular Outcomes

Chronic Diseases and Translational Medicine, Volume 12, Issue 2, Page 85-99, June 2026.
Endogenous GLP‐1 and exogenous GLP‐1 RAs activate GLP‐1R‐expressing vagal afferents in the portal vein, projecting to the nucleus tractus solitarius (NTS). This input engages brainstem–hypothalamic circuits that regulate metabolic homeostasis. Hypothalamic efferent vagal output to the liver suppresses lipogenesis, enhances triglyceride export, and ...
Gabriel Amorim Moreira Alves, Masatoki Teranishi, Rajendranandini Majumdar, Fazal Khan, Mohan Dodeja, Ana Claudia Teixeira de Castro Gonçalves Ortega, Marco Acerboni, Arosh S. Perera Molligoda Arachchige, Frank James   +8 more
wiley   +1 more source

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

eFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang, Ting‐ting Hu, Xiao‐di Zhuang, Yi‐lun Zhou, Xin Qi, Cheng‐bi Cui   +5 more
wiley   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

The Effect of Carvacrol on Lipid Profiles, Oxidative Stress, Inflammatory Markers, and Renal Injury in STZ‐Induced Diabetic Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Carvacrol administration is associated with improvements in lipid profiles, attenuation of oxidative stress, and modulation of inflammatory markers, including C‐reactive protein (CRP). The diagram summarizes systemic effects across major organs, highlighting potential protective roles against inflammation‐related oxidative damage and kidney injury ...
Vida Seyedmousavi Dijvejin, Vahid Asghariazar, Helda Tutunchi, Elnaz Faramarzi, Hamed Shoorei, Rouhallah Moradpour, Mehdi Asghari Vostakolaei   +6 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Alogliptin Reduces Oxidative Stress in Cardiomyocytes and Ameliorates Diabetic Cardiomyopathy via the AURKB/NLGN2 Signaling

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.
ABSTRACT Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus. This study investigated the effects of alogliptin on DCM and its underlying mechanisms. A DCM model was constructed and treated with alogliptin. Downstream targets of alogliptin were screened using bioinformatics analysis.
Li‐Jing Jiao, Jing Zhou, Jing Wang, Si‐Nan Zhao, Zhan‐Sheng Zhao, Qian Wang, Ya‐Nan Xie, Wei Jiao   +7 more
wiley   +1 more source

Fatty Liver Index Shows Poor Discrimination for MRI‐Measured Hepatic Steatosis in African Compared with European Adults

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT Background and Aim The Fatty Liver Index (FLI) is a proxy for hepatic steatosis, but its performance against magnetic resonance imaging (MRI) is unknown in African populations. We evaluated the discriminatory performance of the FLI for detecting hepatic steatosis in European men (EM) and West African men (WAM) in the UK, and Black South ...
Asanda Mtintsilana, Kwazi Gabuza, Melony C. Fortuin‐de Smidt, Jon Hauksson, Oluwatoyosi Bello, Olah Hakim, Gráinne Whelehan, Tommy Olsson, Louise M. Goff, Julia H. Goedecke   +9 more
wiley   +1 more source

Biogenic Silver Nanoparticles in Diabetes: In Vivo Mechanisms, Therapeutic Potential, and Future Perspectives: A Review

MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Biogenic silver nanoparticles exhibit antidiabetic potential by improving glycemic control, enhancing insulin sensitivity, and preserving pancreatic β‐cell function. They act through antioxidant and anti‐inflammatory mechanisms, modulating ROS, NF‐κB, and PI3K/Akt pathways, while providing multi‐organ protection, highlighting their promise as ...
Nourhane A. Darwich, Rana El Hajj, Mahmoud I. Khalil   +2 more
wiley   +1 more source