Results 181 to 190 of about 24,637 (218)

Thiazolidinediones in dermatology

International Journal of Dermatology, 2007
AbstractThiazolidinediones, also known as glitazones, represent a relatively new class of medication used for glycemic control in patients with type II diabetes mellitus. These drugs interact with the peroxisome proliferator‐activated receptor γ, a member of the nuclear receptor superfamily, which in turn heterodimerizes with retinoid X receptors to ...
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Hepatotoxicity of thiazolidinediones

Expert Opinion on Drug Safety, 2003
Thiazolidinediones are insulin sensitisers now widely used for the treatment of Type 2 diabetes mellitus. The initial marketed drug in this class, troglitazone, was removed from the market worldwide after approximately 3 years of use due to rare but severe hepatotoxicity, which sometimes resulted in liver failure leading to the need for liver ...
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Nonhypoglycemic Effects of Thiazolidinediones

Annals of Internal Medicine, 2001
The thiazolidinediones are a new class of compounds for treatment of type 2 diabetes. Troglitazone became available in the United States in 1997 but was withdrawn from the market in March 2000 because it caused severe idiosyncratic liver injury. Rosiglitazone and pioglitazone have been available since 1999.
J M, Quesada-Gómez, I, Serrano-Alferez
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Thiazolidinediones☆

Nihon rinsho. Japanese journal of clinical medicine, 2007
Sunder Mudaliar, Robert Henry
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Rosiglitazone, thiazolidinediones and atherosclerosis

Atherosclerosis, 2010
Thiazolidinediones (TZDs) are extensively used in the treatent of type 2 diabetes since this condition is characterized by nsulin resistance and they sensitize patients to the action of nsulin largely through the suppression of hepatic glucose prouction and the suppression of lipolysis at the adipose tissue evel [1].
Paresh, Dandona, Ajay, Chaudhuri, Husam, Ghanim   +2 more
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Thiazolidinediones and cardiovascular disease

Current Atherosclerosis Reports, 2005
Thiazolidinediones hold promise for reducing cardiovascular events and human atherosclerosis. Similar to statins and angiotensin-converting enzyme inhibitors, peroxisome proliferator activated receptor gamma (PPARgamma) exerts anti-inflammatory and antiatherosclerotic actions in the vessel wall.
Robert, Chilton, Elaine, Chiquette
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Vascular reactivity and thiazolidinediones

The American Journal of Medicine, 2003
Endothelial dysfunction is a critical factor in the development of vascular disease in patients with diabetes mellitus. Maintenance of the vascular tone and luminal diameter of a blood vessel is dependent on the net balance of vasoconstrictor and vasodilator forces. In both diabetes and obesity, vascular reactivity is abnormal.
Paresh, Dandona, Ahmad, Aljada, Ajay, Chaudhuri   +2 more
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Thiazolidinediones

Highlights: Introduction Pharmacology Treatment Advantages/Disadvantages Therapeutic Considerations Monographs ...
Kam L. Capoccia, Peggy Soule Odegard
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Cardiovascular effects of the thiazolidinediones

Diabetes/Metabolism Research and Reviews, 2005
AbstractThiazolidinediones, used for the treatment of diabetes mellitus type 2, modulate gene expression by binding to nuclear transcription factor, peroxisome proliferator‐activated receptor‐gamma. Peroxisome proliferator–activated receptor‐gamma is expressed in several tissues, therefore, thiazolidinediones have biological effects on multiple organ ...
Rehan, Qayyum, Peter, Schulman
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Where thiazolidinediones will fit

Diabetes/Metabolism Research and Reviews, 2002
Individuals with type 2 diabetes have two defects: insulin resistance, which occurs in the first stages of disease progression, and pancreatic beta-cell failure, which occurs later in the disease. Insulin resistance is the major pathological defect. During the course of the disease, insulin levels are initially elevated to compensate for the increased ...
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