Results 11 to 20 of about 2,247 (174)

Gems From the Caves: Genomic Insights Into the Biosynthetic Potential of Antimicrobial-Producing Bacteria Associated With Tropical Cave-Dwelling Sponges. [PDF]

Environ Microbiol
Our study reveals that cave‐dwelling marine sponges host bacteria with antimicrobial activity against multidrug‐resistant strains. The bioactive Pseudomonadaceae strains exhibited biosynthetic clusters encoding both characterized and putative antimicrobial compounds and peptides. The findings highlight their potential for discovering novel biomolecules
Dias GR, de Oliveira BFR, Sandes J, Muricy G, Laport MS.   +4 more
europepmc   +2 more sources

Bioactivity of Novel Pyrazole-Thiazolines Scaffolds against Trypanosoma cruzi: Computational Approaches and 3D Spheroid Model on Drug Discovery for Chagas Disease

Pharmaceutics, 2022
Chagas disease, a century-old disease that mainly affects the impoverished population in Latin America, causes high morbidity and mortality in endemic countries.
Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araújo Souto, Maurício Silva dos Santos, Mirian Claudia de Souza Pereira   +6 more
doaj   +1 more source

Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives

Molecules, 2019
A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques.
Yahia N. Mabkhot, H. Algarni, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Nabila A. Kheder, Zainab M. Almarhoon, Faiz A. Al-aizari   +6 more
doaj   +1 more source

Synthesis and Crystal Structure of 1-(3-fluorophenyl)-3-(3,4,5-trimethoxybenzoyl)thiourea [PDF]

, 2011
The title thiourea was synthesized by reaction of 3,4,5-trimethoxybenzoyl isothiocyante with 3-fluoroaniline. The 3,4,5-trimethoxybenzoyl isothiocyante was produced in situ by reaction of 3,4,5-trimethoxybenzoyl chloride with ammonium thiocyanate in dry ...
Bolte, Michael, Saeed, Aamer, Shaheen, Uzma   +2 more
core   +2 more sources

A straightforward metal-free synthesis of 2-substituted thiazolines in air [PDF]

, 2015
The authors are grateful to the Royal Society (University Research Fellowship to CSJC) for financial support.A base-catalysed procedure for the synthesis of 2-substituted thiazolines from nitriles and cysteamine hydrochloride under solvent-free ...
Cazin, Catherine S.J., Lazreg, Faima, Lesieur, Mathieu, Trose, Michael   +3 more
core   +1 more source

Thiazole and Oxazole Alkaloids: Isolation and Synthesis

Marine Drugs, 2010
Thiazoles, oxazole and their corresponding reduced derivatives, thiazolines and oxazolines, are found in marine sources exhibiting significant biological activities.
Gloria Serra, Danilo Davyt
doaj   +1 more source

O-GlcNAcase:promiscuous hexosaminidase or key regulator of O-GlcNAc signalling? [PDF]

, 2014
O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins.
Banerjee, Butkinaree, Cantarel, Cecioni, Cetinba, Comtesse, Copeland, Dennis, Dong, Dorfmueller, Dorfmueller, Drougat, Forsythe, Francisco, Gao, Gong, Graham, Guinez, Hanover, Hart, Hayakawa, He, He, Heckel, Hilgers, Housley, Howerton, Hu, Itkonen, Keembiyehetty, Knapp, Laczy, Lefebvre, Lepage, Libina, Liu, Macauley, Macauley, Macauley, Macauley, Macauley, Mahuran, Martin, Minami, Müller, Nagel, Olszewski, Ostrowski, Pathak, Penton, Radermacher, Rahman, Rao, Rao, Robinson, Ruan, Ruan, Schimpl, Schimpl, Schultz, Sekine, Shen, Slawson, Speakman, Stryke, Swallow, Tews, Toleman, Toleman, Torres, Wang, Wang, Webster, Wells, Whisenhunt, Whitworth, Yang, Yu, Yuzwa, Yuzwa, Zachara, Zachara, Zhu   +82 more
core   +3 more sources

A Facile Synthesis of 2,4-Disubstituted Thiazoles Using MnO2

Molecules, 2009
Structurally diverse thiazoles with electron-donating and electron-withdrawing groups were conveniently synthesized through manganese dioxide (MnO2) oxidation of the corresponding thiazolines.
Bin Fu, Yan-Bo Yu, Hong-Liang Chen, Xin-Zheng Chen, Li-Yi Wang   +4 more
doaj   +1 more source

Structure of the cyanobactin oxidase ThcOx from Cyanothece sp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD [PDF]

, 2016
Acknowledgements We thank Diamond Light Source for providing access to beamline I23. We also thank Thomas Sorensen and his staff for access to and support on beamline I02.
Bent, Andrew F, Duman, Ramona, Houssen, Wael E, Jaspars, Marcel, Mann, Greg, Mykhaylyk, Vitaliy, Naismith, James H, Thomas, Louise, Wagner, Armin   +8 more
core   +1 more source

Synthesis of 2-(2-R1-Hydrazino)-5-(R2-benzyl)-2-thiazolines on the Basis of Meerweins Arylation Products of Allyl Isothiocyanate

Molecules, 2003
3-Aryl-2-chloropropylisothiocyanates (1) are formed by interaction of arenediazonium chlorides with allyl isothiocyanate. Adducts 1 react with monoacylhydrazines to form 1-acyl-4-(3-aryl-2-chloropropyl)thiosemicarbazides (2a–d).
Mykola I. Ganushchak, Mykola D. Obushak, Volodymyr V. Karpyak   +2 more
doaj   +1 more source