Results 31 to 40 of about 2,247 (174)

Synthesis of Complex Thiazoline‐Containing Peptides by Cyclodesulfhydration of N ‐Thioacyl‐2‐Mercaptoethylamine Derivatives [PDF]

, 2023
Herein we report a mild, efficient, and epimerization‐free method for the synthesis of peptide‐derived 2‐thiazolines and 5,6‐dihydro‐4 H ‐1,3‐thiazines based on a cyclodesulfhydration of N ‐thioacyl‐2‐mercaptoethylamine or N ‐thioacyl‐3 ...
Koch, Lukas, Meleshin, Marat, Schutkowski, Mike, Wiedemann, Christoph   +3 more
core   +1 more source

Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

Beilstein Journal of Organic Chemistry, 2016
Ribosomally synthesised and post-translationally modified peptides (RiPPs) are a large class of natural products that are remarkably chemically diverse given an intrinsic requirement to be assembled from proteinogenic amino acids. The vast chemical space
Andrew W. Truman
doaj   +1 more source

Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives

Molecules, 2014
NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at the C ...
Jana Krejzová, Petr Šimon, Lubica Kalachova, Natallia Kulik, Pavla Bojarová, Petr Marhol, Helena Pelantová, Josef Cvačka, Rüdiger Ettrich, Kristýna Slámová, Vladimír Křen   +10 more
doaj   +1 more source

Multicomponent Assembly of Proposed DNA Precursors in Water [PDF]

, 2012
We propose a novel pathway for the prebiotic synthesis of 2′-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic amino acids, serine and ...
Powner, Matthew W., Szostak, Jack William, Zheng, Shao-Liang   +2 more
core   +1 more source

Flavouring Group Evaluation 76 Revision 2 (FGE.76Rev2): Consideration of sulfur-containing heterocyclic compounds, evaluated by JECFA, structurally related to thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev5 [PDF]

, 2023
The Panel on Food Additives and Flavourings (FAF) was requested to consider the JECFA evaluations of 28 flavouring substances in the Flavouring Group Evaluation 76 (FGE.76Rev2). Twenty-one of these substances have been considered in FGE.76Rev1.
Aquilina, G, Benigni, R, Bolognesi, C, Carfi, M, Castle, L, Chipman, K, Cordelli, E, Degen, G, Engel, KH, Fernandez, MJF, Fnrst, P, Fowler, PJ, Gnrtler, R, Gundert-Remy, U, Husoy, T, Manco, M, Mennes, W, Moldeus, P, Norby, K, Passamonti, S, Shah, RMA, Svendsen, C, Vianello, G, Waalkens-Berendsen, I, Wright, M, Younes, M   +25 more
core   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee, Sihyeong Yi, Juhyun Bang, Hyun Choi, Seung Bum Park   +4 more
wiley   +2 more sources

A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis [PDF]

, 2012
PMCID: PMC3617142This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Alling, T, Bailey, MA, Casey, A, Florio, S, Miller, MJ, Moraski, GC, Ollinger, J, Parish, T   +7 more
core   +2 more sources

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides [PDF]

, 2014
Heterocycle-containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine ...
Craik, Donia, Donia, Driggers, Goto, Houssen, Houssen, Kapust, Katoh, Katsara, Koehnke, Koehnke, Koehnke, Leikoski, McClerren, McIntosh, Melby, Milne, Namjoshi, Plat, Schmidt, Skropeta, Tianero, Villar, White, Wipf, Wipf   +26 more
core   +2 more sources

Dissecting Bottromycin Biosynthesis Using Comparative Untargeted Metabolomics. [PDF]

, 2016
Bottromycin A2 is a structurally unique ribosomally synthesized and post-translationally modified peptide (RiPP) that possesses potent antibacterial activity towards multidrug-resistant bacteria.
Arnison, Böttcher, Crone, Dunbar, Dunbar, Duncan, Dunn, Fernández-Martínez, Flühe, Foulston, Frottin, Gomez-Escribano, Grant, Hegde, Hoffmann, Hou, Hou, Huo, Kaneda, Kaneda, Katoh, Kleigrewe, Kobayashi, Koehnke, Kurita, Lee, Liu, Liu, Matsui, Melby, Nguyen, Schramma, Shimamura, Vizcaino, Vizcaino, Watrous, Wilson   +36 more
core   +2 more sources

Crystal structure of endo‐β‐N‐acetylglucosaminidase HSα

Acta Crystallographica Section F, Volume 82, Issue 3, Page 94-100, March 2026.
Structural analysis of the GH85 enzyme endo‐β‐N‐acetylglucosaminidase HSα reveals a novel domain that is potentially involved in complex N‐glycan recognition.The crystal structure of endo‐β‐N‐acetylglucosaminidase HSα (Endo HSα) was determined at 1.8 Å resolution, revealing that the enzyme is composed of five distinct domains.
Ikuya Kurauchi, Kazuki Okura, Chie Hosokawa, Kazuo Ito, Ikuko Miyahara   +4 more
wiley   +1 more source