Results 31 to 40 of about 312,064 (301)

A quasi-3D hyperbolic shear deformation theory for functionally graded plates [PDF]

, 2013
A quasi-3D hyperbolic shear deformation theory for functionally graded plates is developed. The theory accounts for both shear deformation and thickness-stretching effects by a hyperbolic variation of all displacements across the thickness, and satisfies
Bui, Tinh, Nguyen, Trung-Kien, Thai, Huu-Tai, Vo, Thuc   +3 more
core   +1 more source

A 16-node locking-free Mindlin plate resting on two-parameter elastic foundation- static and eigenvalue analysis

Computer Assisted Methods in Engineering and Science, 2017
The Pasternak elastic foundation model is employed to study the statics and natural frequencies of thick plates in the framework of the finite element method.
Ryszard Buczkowski, Maciej Taczała, Michał Kleiber   +2 more
doaj   +1 more source

A new locking-free polygonal plate element for thin and thick plates based on Reissner-Mindlin plate theory and assumed shear strain fields

, 2018
A new $n-$ noded polygonal plate element is proposed for the analysis of plate structures comprising of thin and thick members. The formulation is based on the discrete Kirchhoff Mindlin theory.
Bordas, Stephane PA, Natarajan, Sundararajan, Videla, Javier   +2 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Application of the Method of Initial Functions to Study Dynamics and Stress Distribution in Structural Members

Advances in Civil Engineering
This study investigates plate analyses employing the method of initial functions (MIFs) across various plate geometries and loading conditions. The conclusions derived from thick rectangular plates highlight substantial thickness-induced effects on ...
Jitendra Namdeo, S. K. Dubey, Rahul Biswas, Rakesh Patel   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Electrostatic depletion forces between planar surfaces [PDF]

, 2008
The interaction between two dielectric plates immersed in an electrolyte solution is examined by using a variational perturbation approximation for the grand partition function.
Curtis, R.A., Hatlo, Marius M., Lue, Leo
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Some results on thermal stress of layered plates and shells by using Unified Formulation [PDF]

, 2013
This work presents some results on two-dimensional modelling of thermal stress problems in multilayered structures. The governing equations are written by referring to the Unified Formulation (UF) introduced by the first author.
Argyris J., Bapu Rao M. N., Brischetto S., Carrera E., Carrera E., Carrera E., Carrera E., Erasmo Carrera, Fazzolari F. A., Fiorenzo Adolfo Fazzolari, Khare R. K., Librescu L., Librescu L., Librescu L., Maria Cinefra, Noor A. K., Noor A. K., Reddy J. N., Srinivas S., Thornton E. A.   +19 more
core   +1 more source