Results 101 to 110 of about 2,202,861 (298)

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain [PDF]

, 2011
Objectives: The thickness of the brain’s cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated
Glahn, David C., Jack eKent, Winkler, Anderson, Stein, JL, Curran, Joanne E., Anderson eWinkler, Melany eCarless, Kent, J, Joanne eCurran, Kochunov, Valeria, Kochunov, V, Joanne E. Curran, Paul eThompson, Kochunov, P, Winkler, AM, Jason eStein, John eBlangero, Kent, Jack, Shelley eCole, Glahn, DC, Stein, Jason L., Carless, Melanie A., Johnson, Matthew P., Hong, EL, Nichols, Thomas E., Thompson, PM, Kochunov, Peter, David C. Glahn, Cole, Shelley A., Henry H. Holcomb, Matthew P. Johnson, Paul M. Thompson, Anderson M. Winkler, Rene L. Olvera, Rene eOlvera, Tom eNichols, Holcomb, Henry H., Olvera, RL, Hong, Elliot L., Thomas E. Nichols, Winkler, Anderson M., MP eJohnson, John Blangero, Curran, JE, Nichols, TE, Melanie A. Carless, Thompson, Paul M., Valeria Kochunov, Elliott eHong, Jack Kent, Olvera, Rene L., Peter eKochunov, Johnson, MP, Valeria eKochunov, Henry eHolcomb, Elliot L. Hong, Holcomb, HH, Blangero, J, Peter Kochunov, Cole, SA, Shelley A. Cole, Carless, MA, Blangero, John, David eGlahn, Jason L. Stein   +64 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Clinical versus Histological Assessment of Basal Cell Carcinoma Subtype and Thickness of Tumours Selected for Photodynamic Therapy

Acta Dermato-Venereologica
Photodynamic therapy is an approved treatment for primary, superficial, and small nodular basal cell carcinomas with a thickness of < 2 mm located on low-risk sites.
Erik Mørk, Patricia Mjønes, Olav A. Foss, Cato Mørk, Ingeborg M. Bachmann, Susanne Kroon, Lars K. Dotterud, Per Helsing, Øystein Vatne, Eidi Christensen   +9 more
doaj   +1 more source

Estimation of WSe2 Layer Thickness using Reflectance Spectra and Comparison with Graphene based on Wavelength [PDF]

E3S Web of Conferences
The purpose of this study is to calculate the WSe2 layer thickness using reflectance spectra and comparison with graphene using wavelength in the Novel 2D material reflectance spectra Using nanoHUB.org, the study’s data was gathered.
Bhavyasri V., Chandra Kishore S.
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

The propagation of hydraulic fracture in layered coal seam: a numerical simulation considering the interface thickness based on the distinct element method

Frontiers in Energy Research
The intercalated layer of coal seam plays an important role in the propagation of hydraulic fracturing. To understand the role of the intercalated layer, a composite coal seam model considering the thickness of the intercalated layer was established ...
Hongye Gao, Hongye Gao, Hongye Gao, Baoshan Jia, Baoshan Jia, Yun Lei, Yongxiang Zheng, Yongxiang Zheng, Bin Shi, Haiyang Wei, Tongjing Zhang, Wei Wang, Wei Wang, Qinghe Niu, Qinghe Niu   +14 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source