Results 81 to 90 of about 2,202,861 (298)
Optimal Design, Reliability And Sensitivity Analysis Of Foundation Plate
Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2015 This paper deals with the optimal design of thickness of a plate rested on Winkler’s foundation. First order method was used for the optimization, while maintaining different restrictive conditions. The aim is to obtain a minimum volume of the foundation Tvrdá Katarínadoaj +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceMeta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]
, 2011 Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.Taylor, K, Rice, K. (Kenneth), Petrovic, K. (Katja), Orru, M, Meisinger, C. (Christa), Fox, Caroline S., Ralph B D'Agostino, Ballantyne, C. (Christie), Rivadeneira Ramirez, F. (Fernando), Demissie, S, Sanna, Serena, Harris, Tamara B, Markus, Hugh S, Petrovic, KE, Huffman, J.E. (Jennifer), White, C.C. (Charles), Heiss, G. (Gerardo), Sanna, S, Eiriksdottir, Gudny, Newman, Anne B, Peltonen, L, Smith, AV, Huffman, JE, Couper, DJ, Huffman, Jennifer E., Blankenberg, Stefan, Baumert, J. (Jens), Lüdemann, Jan, Reinhold Schmidt, Arne Schillert, Sitzer, M, Dörr, M. (Marcus), Manuela Uda, Steve Bevan, Serkalem Demissie, Boerwinkle, Eric, Xia Li, O'Leary, Daniel H, Eiriksdottir, G, Ulf Schminke, O'Donnell, CJ, Wichmann, H.E. (Heinz Erich), Kavousi, M, Halperin, E, Boerwinkle, E, Illig, T. (Thomas), Heiss, G, Heckbert, Susan R, Bis, JC, Tamara B Harris, Harris, T.B. (Tamara), Smith, Albert V, Launer, Lenore J, Ziegler, A, Schmidt, Reinhold, Heckbert, Susan R., Meisinger, Christa, Wild, P.S. (Philipp), Polak, Joseph F., Klopp, Norman, Cupples, L.A. (Adrienne), Joseph F Polak, Aspelund, T. (Thor), Wolf, PA, Couper, David J., Alan R Shuldiner, White, Charles C, Rivadeneira, F, Homuth, G, Gonçalo R Abecasis, Cheng, YC, Maryam Kavousi, Taylor, Kent, White, CC, Li, X. (Xia), ?, ?, Orru, Marco, Wild, PS, Bevan, S, Duijn, Cornelia, Wendy S Post, Abbas Dehghan, Halperin, E. (Eran), Luedemann, Jan, Smith, A.V. (Albert Vernon), Münzel, T, Franceschini, N. (Nora), Kähönen, M, Stoegerer, EM, Baumert, Jens, Reilly, Muredach P., Thomas Illig, Völzke, H. (Henry), Homuth, G. (Georg), D'Agostino, RB, Lenore J Launer, Schminke, Ulf, Christie Ballantyne, Franceschini, N, Uda, Manuela, Wild, Philipp S, Scuteri, Angelo, Huffman, Jennifer E, Rice, Kenneth, Hugh S Markus, Christopher J O'Donnell, Launer, Lenore J., Usala, G, Fernando Rivadeneira, Jacqueline Witteman, Post, WS, Norman Klopp, Gudnason, V. (Vilmundur), Petrovic, Katja E., Mitchell, BD, Uitterlinden, Andre, Post, W.S. (Wendy S.), Wolf, Philip A, Reilly, M.P. (Muredach), Rotter, Jerome I, Franceschini, Nora, Newman, Anne B., Andreas Ziegler, Marco Orru, Uitterlinden, A, Fox, CS, Dörr, Marcus, Schnabel, R.B. (Renate), Edward G Lakatta, Nambi, Vijay, Isaacs, Aaron; id_orcid, Cheng, Yu-Ching, Uitterlinden, A.G. (André), Ben Oostra, Wilson, James F, Stefan Blankenberg, Schmidt, Helena, O'Donnell, C.J. (Christopher), Koenig, W, Völzke, H, Reilly, MP, Thomas Münzel, Mika Kähönen, Dehghan, Abbas, Gudnason, V, Bevan, Steve, Raitakari, O, Thorsson, Bolli, Yu-Ching Cheng, Isaacs, A.J. (Aaron), Caroline S Fox, Koenig, Wolfgang, Albert V Smith, Cupples, LA, Rathmann, W, Bruce M Psaty, Andre Uitterlinden, Zeller, T, Smith, Albert V., Shuldiner, Alan R, Florian Ernst, Ballantyne, C, Kavousi, M. (Maryam), Chilukoti, R.K. (Ravi Kumar), Ziegler, Andreas, Duijn, CV, Schillert, A, Lakatta, Edward G., Psaty, B.M. (Bruce), Homuth, Georg, Harris, TB, O'Leary, D.H. (Daniel H.), Ernst, Florian, Raitakari, Olli, Post, Wendy S, Shuldiner, AR, Demissie, S. (Serkalem), Abecasis, GR, Oostra, B.A. (Ben), Schnabel, RB, Joshua C Bis, Wilson, James F., Kathiresan, S. (Sekar), Gerardo Heiss, Thor Aspelund, Hofman, Albert, Eric Boerwinkle, Illig, Thomas, Mitchell, B.D. (Braxton), Schillert, Arne, Hayward, C, Voelzke, Henry, North, K, Polak, Joseph F, Polak, JF, Halperin, Eran, Lehtimäki, T. (Terho), Tanja Zeller, Lakatta, E. (Edward), Joachim Thiery, Helena Schmidt, David J Couper, Aaron Isaacs, Demissie, Serkalem, Rotter, JI, Seissler, J. (Jochen), Petrovic, Katja E, Chilukoti, Ravi Kumar, Duijn, C.M. (Cornelia) van, Thiery, Joachim, Thorsson, B. (Bolli), Schillert, A. (Arne), Psaty, Bruce M., Mitchell, Braxton D., Henry Völzke, Kenneth Rice, Lüdemann, J, Lehtimaki, Terho, Isaacs, A, Marcus Dörr, Matthias Sitzer, Witteman, Jacqueline, Uda, M. (Manuela), Bis, Joshua C, Lehtimäki, T, Shuldiner, A.R. (Alan), Bevan, S. (Steve), null null, Serena Sanna, H Erich Wichmann, Lakatta, EG, Abecasis, G.R. (Gonçalo), Parsa, Afshin, Bis, J.C. (Joshua), Uda, M, Wichmann, H Erich, Blankenberg, S. (Stefan), Shuldiner, Alan R., Anne B Newman, Hofman, Bert, North, Kari, Thiery, J.P. (Joachim), Dörr, M, Afshin Parsa, Vijay Nambi, Zeller, Tanja, Schminke, U. (Ulf), Chilukoti, RK, Leena Peltonen, Rotter, J.I. (Jerome), Psaty, Bruce M, Heckbert, SR, Dehghan, A, Nambi, V, Witteman, J, Polak, J.F. (Joseph F.), Jorma Viikari, Kari North, Eran Halperin, Daniel H O'Leary, Wolf, Philip A., Seissler, Jochen, Usala, G., O'Leary, DH, Heckbert, S.R. (Susan), Ballantyne, Christie, Nora Franceschini, North, K.E. (Kari), Jennifer E Huffman, Jan Lüdemann, Vilmundur Gudnason, Meisinger, C, Jens Baumert, Rivadeneira, Fernando, Ziegler, A. (Andreas), O'Donnell, Christopher J., Eiriksdottir, G. (Gudny), Kathiresan, S, Wolf, P.A. (Philip), Cheng, Y.C. (Yu Ching), van Duijn, Cornelia, Rathmann, Wolfgang, Wolfgang Koenig, Zeller, T. (Tanja), Peltonen, Leena, Kent Taylor, Kähönen, M. (Mika), D'Agostino, Ralph B, Olli Raitakari, Völzke, Henry, Ernst, F, Mitchell, Braxton D, Wichmann, HE, Heiss, Gerardo, Muenzel, Thomas, Abecasis, Goncalo R., Koenig, W. (Wolfgang), James F Wilson, Viikari, J. (Jorma), Wilson, James F; id_orcid, Boerwinkle, E.A. (Eric), Susan R Heckbert, Markus, HS, Seissler, J, Bis, Joshua C., O'Leary, Daniel H., Klopp, N, Ravi Kumar Chilukoti, Stoegerer, E.M. (Eva Maria), Usala, Gianluca, Fox, C.S. (Caroline), Caroline Hayward, Harris, Tamara B., Li, X, Parsa, A, Jochen Seissler, Abecasis, Gonçalo R, Illig, T, Jerome I Rotter, Cupples, L Adrienne, Cupples, L. Adrienne, Launer, LJ (Lenore), Gudnason, Vilmundur, Lakatta, Edward G, Schmidt, R, Scuteri, A, Bolli Thorsson, Stoegerer, Eva-Maria, Uitterlinden, André; id_orcid, Post, Wendy S., Schmidt, R. (Reinhold), Schmidt, H, Kahonen, Mika, Cornelia van Duijn, Angelo Scuteri, Philipp S Wild, Viikari, J, Schnabel, Renate B, Baumert, J, Peltonen, L. (Leena Johanna), Renate B Schnabel, Sekar Kathiresan, Muredach P Reilly, D'Agostino, Ralph Sr., Rice, K, Philip A Wolf, Parsa, A. (Afshin), Doerr, Marcus, Orrù, M. (Marco), White, Charles C., Dehghan, A. (Abbas), Hayward, Caroline, Hofman, A. (Albert), Münzel, Thomas, Witteman, JCM, Blankenberg, S, Albert Hofman, Schnabel, Renate B., O'Donnell, Christopher J, D'Agostino, Ralph B., Sr., Sitzer, Matthias, CARDIoGRAM Consortium, Katja E Petrovic, Viikari, Jorma, Oostra, B, Ernst, F.D.J. (Florian), Aspelund, T, Rathmann, W. (Wolfgang), D'Agostino, R.B. (Ralph), Couper, D.J. (David), Couper, David J, Thorsson, B, Psaty, BM, Wolfgang Rathmann, Hayward, C. (Caroline), Oostra, Ben, Aspelund, Thor, Reilly, Muredach P, Georg Homuth, Markus, H.S. (Hugh S.), Lüdemann, J. (Jan), Gianluca Usala, Taylor, K.D. (Kent), Isaacs, Aaron, Wichmann, H. Erich, Raitakari, O. (Olli), Hofman, A, Kathiresan, Sekar, Wilson, JF, Launer, L.J. (Lenore), Markus, Hugh S., Schminke, U, Charles C White, Launer, LJ, Thiery, J, Sanna, S. (Serena), Duijn, Cornelia van, Newman, AB, Newman, A.B. (Anne), Christa Meisinger, Witteman, J.C.M. (Jacqueline), Klopp, N. (Norman), Wild, Philipp S., Wilson, J.F. (James), Eva-Maria Stoegerer, Hayward, Caroline; id_orcid, Kavousi, Maryam, Nambi, V. (Vijay), Sitzer, M. (Matthias), Rotter, Jerome I., Münzel, T. (Thomas), Gudny Eiriksdottir, Braxton D Mitchell, L Adrienne Cupples, Terho Lehtimäki, Li, Xia, Scuteri, A. (Angelo), Fox, Caroline S +417 morecore +1 more sourceSpatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours +11 morewiley +1 more sourceDouble Laser for Depth Measurement of Thin Films of Ice
Sensors, 2015 The use of thin films is extensive in both science and industry. We have created an experimental system that allows us to measure the thicknesses of thin films (with typical thicknesses of around 1 µm) in real time without the need for any prior ...Manuel Domingo Beltrán, Ramón Luna Molina, Miguel Ángel Satorre Aznar, Carmina Santonja Moltó, Carlos Millán Verdú +4 moredoaj +1 more sourceZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach +11 morewiley +1 more sourceCirculating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong +6 morewiley +1 more source
