Results 71 to 80 of about 2,292,500 (303)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Thickness on Ferroelectric Properties of Bi_3.25La_0.75Ti₃O₁₂ Thin Films

Ceramics
The pursuit of low-power/low-voltage operation in devices has prompted a keen interest in the mesoscale effects within ferroelectric thin films. The downsizing of ferroelectrics can significantly influence performance; for instance, the remanent ...
Wenfeng Yue, Yali Cai, Quansheng Guo, Dawei Wang, Tingting Jia   +4 more
doaj   +1 more source

Thickness variations in electrolytes for planar solid oxide fuel cells

Journal of Asian Ceramic Societies, 2019
Shape uniformity is one of the key factors for determining the performance of planar solid oxide fuel cells. Three parameters must be considered to acquire a full picture of shape uniformity: the extent of warpage, surface roughness and thickness ...
Ching-Ti Kao, Wei-Hsing Tuan, Shu-Wei Chang   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Thickness-Dependent Raman Scattering from Thin-Film Systems

, 2023
The intensity of the Raman signal from a thin-film multilayer varies nonmonotonically with the thickness of the thin-film layers due to interference of the excitation and Raman scattered light within the films.
Xinwei Wang (352488), Hamidreza Zobeiri (12060519), Hamidreza Zobeiri, Nathan Van Velson (14563215), Xinwei Wang, Nathan Van Velson   +5 more
core   +1 more source

Preliminary Assessments of Geotechnical Seismic Isolation Design Properties

Infrastructures
This paper proposes a method to investigate the design properties of geotechnical seismic isolation (GSI). This technique has been the object of many research contributions, both experimental and numerical.
Davide Forcellini
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Whale Optimization Algorithm-Based Data Fitting Method to Determine the Parameters of Films Measured by Spectroscopic Ellipsometry

Photonics
A data-fitting method based on the whale optimization algorithm (WOA) is proposed to determine the thickness and refractive index of films measured by spectroscopic ellipsometry (SE).
Liyuan Ma, Xipeng Xu, Changcai Cui, Mai Gao, Tukun Li, Shan Lou, Paul J. Scott, Xiangqian Jiang, Wenhan Zeng   +8 more
doaj   +1 more source

Optimal Design, Reliability And Sensitivity Analysis Of Foundation Plate

Transactions of the VŠB: Technical University of Ostrava, Civil Engineering Series, 2015
This paper deals with the optimal design of thickness of a plate rested on Winkler’s foundation. First order method was used for the optimization, while maintaining different restrictive conditions. The aim is to obtain a minimum volume of the foundation
Tvrdá Katarína
doaj   +1 more source