Results 131 to 140 of about 910 (153)

ChemInform Abstract: TOTAL SYNTHESIS OF THIENAMYCIN ANALOGS. 1. SYNTHESIS OF THE THIENAMYCIN NUCLEUS AND DL‐DECYSTEAMINYLTHIENAMYCIN

Chemischer Informationsdienst, 1979
AbstractAusgehend von dem Azetidinon (I) bzw. dem Oxaazabicyclooctanon (Va) wird das Carbapenem‐carboxylat (IVb) bzw. das dl‐Descysteaminylthienamycinsalz dl‐(VIIIb) synthetisiert.
L. D. CAMA, B. G. CHRISTENSEN
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ChemInform Abstract: THIENAMYCIN TOTAL SYNTHESIS. 1. SYNTHESIS OF AZETIDINONE PRECURSORS OF (.+‐.)‐THIENAMYCIN AND ITS STEREOISOMERS

Chemischer Informationsdienst, 1980
AbstractIm Zusammenhang mit der Synthese des antibiotisch wirksamen Thienamycins (XIV) werden verschiedene Modellreaktionen beschrieben.
F. A. BOUFFARD, D. B. R. JOHNSTON, B. G. CHRISTENSEN   +2 more
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Antibacterial Activity of Imipenem: The First Thienamycin Antibiotic

Clinical Infectious Diseases, 1985
Imipenem (N-formimidoyl thienamycin) is the first representative of a new class of beta-lactam antibiotics--the carbapenems. Imipenem has an unusually broad spectrum, high potency, and no cross-resistance with other beta-lactam antibiotics. Susceptible gram-negative species include Pseudomonas aeruginosa, Serratia, and Enterobacter.
H, Kropp, L, Gerckens, J G, Sundelof, F M, Kahan   +3 more
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Thienamycin. A solution of the stereochemical problem

Tetrahedron Letters, 1979
Abstract A new nitrone-based synthesis of β-lactams is described which makes provision for the 1-hydroxyethyl moiety in the potent antibiotic thienamycin. Moreover, the relative stereochemical features of the natural product are defined in a step involving the cycloaddition of a nitrone with methyl crotonate.
Joseph J. Tufariello, George E. Lee, Pushpananda A. Senaratne, Mohammed Al-Nuri   +3 more
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Imipenem: The First Thienamycin Antibiotic

Clinical Infectious Diseases, 1985
A M, Geddes, W, Stille
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Imipenem: the first thienamycin antibiotic.

Postgraduate medical journal, 1987
Imipenem is a new beta-lactam which differs chemically from penicillins and cephalosporins but has a similar mode of action. It is a potent antibacterial agent with a broad spectrum of activity encompassing both aerobes and anaerobes. However, in vitro, it does not appear to offer a great improvement over other available agents for the treatment of ...
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In vitro activity of thienamycin.

Methods and findings in experimental and clinical pharmacology, 1982
The in vitro activity of thienamycin was determined simultaneously in Müller-Hinton broth and peptone broth. Minimum inhibitory and bactericidal concentrations were compared to those of 4 aminoglycosides and 3 cefalosporins. The activity of thienamycin against gram-negative aerobic bacterial was influenced by the media.
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[N-Formimidoyl-thienamycin in Animal Studies].

Arzneimittel-Forschung, 1983
The beta-lactam antibiotic thienamycin is rather unstable and is metabolized in man by renal dehydropeptidase-I. The derivatives of the antibiotic, especially N-formimidoyl-thienamycin (MK-0787) are reported to be more resistant. The antibacterial activity of N-formimidoyl-thienamycin was tested by means of the infection- and therapy model of the acute,
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Thienamycin total synthesis. 3. Total synthesis of (.+-.)-thienamycin and (.+-.)-8-epithienamycin

The Journal of Organic Chemistry, 1980
Susan M. Schmitt, David B. R. Johnston, B. G. Christensen   +2 more
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Total synthesis of (.+-.)-thienamycin

Journal of the American Chemical Society, 1978
David B. R. Johnston, Susan M. Schmitt, F. Aileen Bouffard, B. G. Christensen   +3 more
openaire   +1 more source