Results 71 to 80 of about 1,228,239 (309)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
PENGARUH PENGGUNAAN METODE GUIDED INQUIRY DAN GAYA BERPIKIR TERHADAP HASIL BELAJAR KOGNITIF KELAS V
Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan, 2017 The research aims to determine the effect of use of guided inquiry method and thinking stlye on cognitive learning outcomes of classroom at 5th grade elementary school. The design of this research used a quasi-experimental design factorial 2x2.
Heri Susanto +2 more
doaj +1 more source
Analysis Students' Critical Thinking Skills in Solving Problems in Terms of Cognitive Style [PDF]
, 2019 Tujuan dari penelitian ini adalah untuk menganalisis kemampuan berpikir kritis siswa dalam menyelesaikan masalah yang ditinjau dari gaya kognitif. Penelitian ini termasuk dalam Penelitian Kualitatif dengan metode deskriptif kualitatif.
Amini, N. U. (Nisa) +2 more
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Frontiers in Psychology, 2019 Background: Metacognitive therapy (MCT) is a modern approach with demonstrated efficacy in current major depressive disorder (MDD). The treatment aims to modify thinking styles of rumination and worry and their underlying metacognitions, which have been ...
Lotta Winter +6 more
doaj +1 more source
The contribution of teamwork, thinking styles, and innovation towards knowledge management [PDF]
, 2009 Knowledge management can be enhanced by creating conditions that facilitate knowledge creation, thus the concepts of teamwork,thinking styles, and innovation are central to the effective utilisationof knowledge.
Ratnasingam, Malini
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source