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Toxicokinetics and toxicity of thioacetamide sulfoxide: a metabolite of thioacetamide

Toxicology, 2007
Thioacetamide (TA) is bioactivated by CYP2E1 to TA sulfoxide (TASO), and to the highly reactive sulfdioxide (TASO(2)), which initiates hepatic necrosis by covalent binding. Previously, we have established that TA exhibits saturation toxicokinetics over a 12-fold dose range, which explains the lack of dose-response for bioactivation-based liver injury ...
Ronald Hill   +2 more
exaly   +3 more sources

Review on the genotoxic activity of thioacetamide

Mutation Research - Reviews in Genetic Toxicology, 1989
Article de synthese sur la genotoxicite de la thioacetamide, un fongicide et un substitut du sulfure d'hydrogene en laboratoire en vue d'evaluer le risque mutagenique et l'activite ...
exaly   +3 more sources

Inhibition of δ-aminolevulinic acid synthetase by thioacetamide and thioacetamide-S-oxide

Biochemical Pharmacology, 1978
Abstract Thiocetamide and one of its metabolites, thioacetamide- S -oxide, were shown to inhibit δ-aminolevulinic acid (ALA) synthetase when administered in vivo to adult male mice. Thioacetamide and thioacetamide- S -oxide also inhibited the 3,5-dicarboethoxy-1,4-dihydrocollidine (DDC)-mediated induction of ALA synthetase when given either 1hr ...
T, Yoshida, R A, Neal
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Selection of albumin mRNA by thioacetamide

Biochemical and Biophysical Research Communications, 1976
Summary After thioacetamide administration to rats, most of the labeled aminoacids incorporated into liver proteins are recovered in polypeptides with the same mobility as rat-serum albumin, which can be selectively immunoprecipitated by anti-rat albumin serum.
A M, Stolf   +6 more
openaire   +2 more sources

Argentomctric coulomelric titration of thioacetamide

Talanta, 1968
The coulometric determination of thioacetamide (TAA) with electrogenerated silver is described. The titration is done in a solution 0.1M in both ammonia and sodium hydroxide, and the end-point is detected potentiometncally with a silver-silver sulphide electrode. On repeat analyses of approx.
D M, King, W S, Eaton
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Thioacetamide-Induced Hepatocarcinoma in Rat

Oncology, 2009
Out of 56 thioacetamide (TAA)-fed rats hepatocellular carcinoma were found in four instances after 300, 360, 450 and 495 days in the present experiment. Of the four tumours, two showed lung metastasis. The size of TAA-treated hepatocyte nucleoli increased greatly after several weeks of feeding.
A, Dasgupta   +2 more
openaire   +2 more sources

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