Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy [PDF]
Therapeutics and Clinical Risk Management, 2011 Courtney E McIlduff, Seward B RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USABackground: The most common of the neuropathies associated with diabetes mellitus, diabetic sensorimotor polyneuropathy (DSPN) is a ...
McIlduff CE, Rutkove SB
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Frontiers in Pharmacology, 2021 Peripheral neuropathies, characterized by altered nociceptive and muscular functions, are related to oxidative stress. Thioctic acid is a natural antioxidant existing as two optical isomers, but most clinically used as racemic mixture.
Alessandra Pacini +7 more
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Modern Approaches to the Technology of Tablet Dosage Forms of Thioctic Acid (Review)
Разработка и регистрация лекарственных средств, 2021 Introduction. Thioctic (α-lipoic) acid is an endogenous antioxidant and is used for liver diseases, poisoning with salts of heavy metals, hyperlipidemia, atherosclerotic heart disease, neuropathy, insulin-resistant forms of diabetes mellitus, etc ...
S. N. Egorova +4 more
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Comparative Dissolution Kinetics of Several Multisource Thioctic Acid Products
Регуляторные исследования и экспертиза лекарственных средств, 2022 The relationship between dissolution and bioavailability is an example of the interdependency between the quality of a medicinal product and its safety and efficacy.
G. F. Vasilenko +6 more
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Качественная клиническая практика, 2021 Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals.
E. V. Eliseeva +4 more
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INVESTIGATION OF THE PHARMACO-TECHNOLOGICAL PROPERTIES OF SOLID DISPERSIONS OF THIOCTIC ACID, OBTAINED BY MICRONIZATION [PDF]
Annals of Mechnikov's Institute, 2018 Introduction. Thioctic acid is used in the treatment of diseases that are characterized by lack of mitochondrial activity, which is responsible for the formation of free radicals. Widespread use of thioctic acid is due to the chemical structure.
Kovalevska, I. V., Ruban, O. A.
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Spectrophotometric determination of thioctic (α-lipoic) acid in water and pharmaceutical preparations [PDF]
Journal of the Serbian Chemical Society, 2007 A spectrophotometric method is described for the assay of thioctic acid. The method is based on the reaction between the drug and palladium(II) chloride.
Korićanac Zagorka +3 more
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Effects of stereoisomers of thioctic acid on rat renal vasculature microanatomy [PDF]
, 2012 Metabolism of oxygen by cells can generate potentially dangerous reactive oxygen species (ROS). Endothelial cells lining vascular luminal surface are an important site of signalling molecules and a ROS target during ischemia, inflammation and other ...
AMENTA, Francesco +4 more
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Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair
Bioactive Materials, 2023 Hydrogel products for chronic diabetic wounds, a serious and prevalent complication of diabetes, show limited effects on disability and remain nonspecific.
Chunxiao Chai +8 more
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Studies on the sulfation of cellulose α-lipoate and ability of the sulfated product to stabilize colloidal suspensions of gold nanoparticles [PDF]
, 2015 © 2015 Elsevier Ltd. A versatile method for the synthesis of cellulose α-lipoate with a low degree of substitution (DS) has been developed using N,N-dimethylacetamide (DMA)/LiCl as a solvent and N,N′-carbonyldiimidazole (CDI) as an esterification reagent.
Cheng, Fei +4 more
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