Results 171 to 180 of about 14,774 (209)
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Deoxythioguanosine and thioguanine
Clinical Pharmacology & Therapeutics, 1973Incorporation of 6‐thioguanine (TG) and β‐2'‐deoxythioguanosine (β‐TGdR) into the DNA and RNA of human bone marrow and tumors were measured. The ratio of incorporation into DNA vs that into RNA was taken as an indication of the extent to which β‐TGdR was a direct precursor for DNA synthesis without conversion to TG.
G A, LePage, J A, Gottlieb
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Fluorometric Assay of Thioguanine
Journal of Pharmaceutical Sciences, 1975A spectrophotofluorometric method is described for the assay of thioguanine. The assay involves the oxidation of thioguanine with potassium permanganate to a fluorescent product. The method is suitable for routine quality control in laboratory preparations of thioguanine.
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Thioguanine-Induced Symptomatic Thrombocytopenia
The American Journal of Gastroenterology, 2004TO THE EDITOR: Currently, the role of thioguanine (6-TG) as an alternative immunosuppressant for the treatment of resistant Crohn’s disease is under investigation. The results from preliminary studies initially suggested that the drug is well tolerated by most of the patients without causing major adverse effects (1–3), whereas in a recent report 26 ...
Heimo H. Wenzl +3 more
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TREATMENT OF PSORIASIS WITH 6‐THIOGUANINE
Australasian Journal of Dermatology, 1988SummaryFifty‐four patients with Psoriasis were treated with the antimetabolite, 6‐thioguanine (TG). Three were early drop‐outs due to side effects. Of 48 evaluable patients with plaque‐type lesions, mostly extensive, 79% achieved over 75% improvement as an initial response, 8% had over 50% improvement and 13% had less than 50% improvement. 65% retained
H S, Zackheim, H I, Maibach
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Transglycosylation Reactions of 6-Thioguanine Acyclonucleosides
Nucleosides, Nucleotides and Nucleic Acids, 20009-(2-Acetoxyethoxy)methyl-N2-acetyl-6-thoguanine (2) undergoes two different transglycosylation reactions: i) the 79 isomerization, which gives the respective 7-regioisomer (3) as the major product, ii) the 9S6 glycosyl migration, which leads to a 9,S6-disubstituted product (4). S6-Methylation completely stopped the reversibility of transglycosylation.
A, Manikowski, J, Boryski
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6-Thioguanine Metabolism in Human Erythrocytes
1991Thiopurines must undergo enzymatic conversion into a variety of nucleotide derivatives in order to display cytotoxic activity [1]; the major ones in human erythrocytes are the 6-thioguanine nucleotides [2]. These compounds derive from the immunosuppressive agent azathioprine as well as from the cytotoxic drugs 6-thioguanine and 6-mercaptopurine [3 ...
A. Lucano, C. Crifo, SALERNO, Costantino
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6-Thioguanine fromErwinia amylovora
Current Microbiology, 1986Erwinia amylovora, the etiological agent of fireblight disease, was found to produce under aerobic conditions in axenic culture 2-amino-1,7-dihydro-6H-purine-6-thion (6-thioguanine, 6-TG), easily recognized by a UV absorbance at 340 nm (pH≤7) and readily distinguished from NADH by both its acid stability and the pH dependence of its UV spectrum.
Gottfried Feistner, Carle M. Staub
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Stability of compounded thioguanine oral suspensions
American Journal of Health-System Pharmacy, 2011PURPOSE. Updated information on the stability of compounded thioguanine oral suspensions prepared with currently available ingredients, as well as results of testing to determine if the addition of an antioxidant could extend shelf life by inhibiting formation of guanine, are presented. METHODS.
Hamidreza Montazeri, Aliabadi +4 more
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Encapsulation of thioguanine in liposomes
International Journal of Pharmaceutics, 1995Abstract Thioguanine, a chemotherapeutic drug employed in the treatment of leukemia, was encapsulated in three kinds of liposomes: extrusion, ethanol injection and dehydration-rehydration vesicles. The degree of entrapment was examined at three different concentrations, 1, 0.1 and 0.01 mM, and three pH values, 4.7, 7.4 and 9.2.
Mercè Foradada, Joan Estelrich
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Correction: Dosage of Thioguanine
Annals of Internal Medicine, 1975Excerpt To the editor: In the letter "Hyperphosphatemia and Hypocalcemia in Myeloproliferative Disorder" (Ann Intern Med81:119-120, 1974), the dose of thioguanine was published as 25 mg/kg body wei...
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