Zeitschrift für Naturforschung B, 1976 Treatment of 5-arylidene-2-thiohydantoin (1a-d) with alkyl bromoacetate and chloroacetic acid gave the esters 2a-f and the acids 2g-j, respectively. 2a was refluxed with concentrated hydrochloric acid to give 5-benzylidene hydantoin. 2 was cyclized with acetic anhydride to give the bicyclic product 3. 5-Arylidene-2-thiohydantoin derivatives (1a, b) and
A. F. A. Shalaby +2 more
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Synthesis, characterization and biological evaluation of some substituted thiohydantoins
, 2007 Thiohydantoins have been proven to have anticonvulsant and antidepressant activity. Some derivatives of thiohydantoin containing both aryl group and benzylidene nucleus were synthesised and their anticonvulsant activity were investigated by ...
Ramachandran, S. +3 more
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Sequencing of peptoid peptidomimetics by Edman degradation
, 1998 The direct identification of resin-bound peptoid peptidomimetics by sequencing is described. The N-terminus of the peptoid was treated with phenyl isothiocyanate, after which the N-terminal peptoid residue was cleaved from the resin as its thiohydantoin ...
Boeijen, A., Liskamp, R.M.J.
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One-pot three-step solution phase syntheses of thiohydantoins using microwave heating
, 2001 An efficient one-pot three-step solution phase protocol suitable for library syntheses of thiohydantoins was developed. The reactions included are in the following order, Negishi or Suzuki C-C coupling reactions, reductive amination and finally a ...
Ohberg, L., Westman, J.
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Solution-Phase Synthesis of a Combinatorial Thiohydantoin Library1
, 2016 An efficient one-pot three-component synthesis of thiohydantoins was developed. In the first step, amino acid esters were alkylated by imine formation with aldehydes and reduction by sodium triacetoxyborohydride.
Mui Mui Sim (3030531) +1 more
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Synthesis, antimicrobial and anticancer activities of some 2-thiohydantoin derivatives [PDF]
, 2017 641-648The vital organic compound 3-[(2-hydroxy-3-methoxybenzylidene)- amino]-2-thiohydantoin 3 has been prepared via the reaction of 2-hydroxy-3-methoxybenzaldehyde 1 with thiosemicarbazide to give N-[(2-hydroxy-3-methoxybenzylidene) amino]thiourea 2 ...
Abubshait, Samar A
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Preparação de sais de isotiourônio as partir de brometos alílicos e tioureias: avaliação da atividade antitumoral e aplicações na síntese de 2-iminotiazolidinas e derivados [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015.Este trabalho apresenta o desenvolvimento de métodos simples e eficientes para a síntese de ...
Ferreira, Misael
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1H NMR kinetic and mechanistic study of the formation of amino acid derived N-allyl-2-thiohydantoins
, 2018 The reaction between amino acid esters and allyl isothiocyanate leading to the formation of N-allyl-2-thiohydantoin derivatives is investigated using 1H NMR spectroscopy.
Živković, Marija +3 more
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Hypothyroidism caused by apalutamide. [PDF]
CMAJ, 2023 Daviduck Q, North S, Swaleh R.
europepmc +1 more source
Síntese de sais de isotiourônio e sua versatilidade em reações de acetilação e na preparação de heterociclos multifuncionalizados [PDF]
, 2011 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2011O presente trabalho foi desenvolvido visando à obtenção de novos compostos orgânicos ...
Ferreira, Misael
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