Results 71 to 80 of about 697 (188)

Synthesis of Thiohydantoin-Castanospermine Glycomimetics as Glycosidase Inhibitors

The Journal of Organic Chemistry, 2009
The preparation of bicyclic carbohydrate mimics related to (+)-castanospermine incorporating a thiohydantoin moiety is reported. The synthetic approach is compatible with molecular diversity-oriented strategies and involves alpha-azidoesters, built at the C-5/C-6 segment in gluco- or galactofuranose scaffolds, as the key precursors.
Aguilar Moncayo, Matilde, Ortiz-Mellet, Carmen, García-Fernández, José Manuel, García Moreno, María Isabel   +3 more
openaire   +3 more sources

Synthesis and characterization of a methacrylate monomer with a thiohydantoin structure

Journal of Oral Science, 2020
The purpose of the current study was to synthesize a methacrylate monomer with a thiohydantoin structure. In a flask, (2-thiohydantoin-4-yl) propionic acid, 10-hyroxydecyl methacrylate, 4-dimethylaminopyridine, and tetrahydrofuran (THF) were placed in a nitrogen atmosphere.
Matsumura, Hideo, Kojima, Katsunori, Mio, Shigeru, Yamamoto, Takashi, Kodaira, Akihisa, Koizumi, Hiroyasu   +5 more
openaire   +3 more sources

Proton magnetic resonance study of the conformation of the pyrrolidine ring in some proline-thiohydantoins

, 1988
The conformational behaviour of a series of N-substituted thiohydantoins of proline was studied by proton NMR. The pseudorotational parameters of the proline moiety were calculated from the ten vicinal proton-proton coupling constants assuming a two ...
Marc J. O. Anteunis, Frans A. M. Borremans, Borremans, Frans, Jef J. M. Sleeckx, Anteunis, Marc, Sleeckx, Jef   +5 more
core   +1 more source

Density Functional Theory Guided Design of Exo-Selective Dehydroalanine Dienophiles for Application Toward the Synthesis of Palau'amine

, 2016
Diels−Alder cycloadditions of dehydroalanine derivatives with cyclopentadiene, applicable to the synthesis of palau'amine, were investigated experimentally and using DFT computations at the B3LYP/6-31G* level of theory.
James L. Gleason (1853971), Timothy A. Cernak (2460220)   +1 more
core   +2 more sources

Synthesis of 3-substituted 5-arylidene-1-methyl-2-thiohydantoins under microwave irradiation

, 2002
A mono-modal microwave oven was used to expedite the synthesis of small libraries of 3-substituted 1-methyl-2-thiohydantoins and 3-substituted 5-arylidene-1-methyl-2-thiohydantoins.
Nielsen, John, Khodair, Ahmed I., Khodari, A.I.   +2 more
core  

Conventional and microwave-assisted synthesis of 1,5-diaryl-2-thiohydantoins

, 2012
891-894A simple and efficient method for synthesis of new 1,5-diaryl-2-thiohydantoins using microwave radiation has been standardized. The compounds have been synthesized from phenyl¬acetic acid by esterification, bromination, amination and cyclization ...
Baile, M B, Mahajan, S S
core  

Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.

, 2005
A set of 30 substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one (thiohydantoins) derivatives was synthesized, and their affinity for the human CB(1) cannabinoid receptor has been evaluated.
Wouters, Johan, Muccioli, Giulio, Martin, Diana, Scriba, Gerhard K E, Wouters, Johan; id_orcid, Poupaert, Jacques, Poppitz, Wolfgang, Lambert, Didier, Poupaert, Jacques H., Muccioli, Giulio G., Lambert, Didier M.   +10 more
core   +1 more source

Kinetics and mechanism of racemisation reactions of configurationally labile stereogenic centres in drug-like molecules in aqueous solutions; thiohydantoins and related compounds [PDF]

In this thesis, studies of the kinetic and mechanism of racemisation of several drug-like molecule have been presented. Chapter 1 provides background information on the general mechanisms of racemisation of drugs in general, and hydantoin derivatives. In
Ahmad, Hiwa Omer
core  

Substituted 5,5‘-Diphenyl-2-thioxoimidazolidin-4-one as CB₁ Cannabinoid Receptor Ligands:  Synthesis and Pharmacological Evaluation

, 2016
A set of 30 substituted 5,5‘-diphenyl-2-thioxoimidazolidin-4-one (thiohydantoins) derivatives was synthesized, and their affinity for the human CB1 cannabinoid receptor has been evaluated.
Jacques H. Poupaert (2069590), Diana Martin (812227), Wolfgang Poppitz (2651602), Johan Wouters (49810), Gerhard K. E. Scriba (2113489), Giulio G. Muccioli (199353), Didier M. Lambert (199355)   +6 more
core   +1 more source

It is “2-imino-4-thiazolidinones” and not thiohydantoins as the reaction product of 1,3-disubstituted thioureas and chloroacetylchloride

, 2008
The products obtained by the reaction of 1,3-disubstituted thioureas with chloroacetylchloride are actually 2-imino-4-thiazolidinone derivatives and not thiohydantoins as previously reported (M. Kidwai, R. Venkataraman and B. Dave, Green. Chem., 2001, 3,
Ghosh, Harisadhan, Yella, Ramesh, Patel, Bhisma K.   +2 more
core   +1 more source