Results 51 to 60 of about 427,077 (192)

The relationship between thiol-disulfide balance and prostate cancer

Medicine Science, 2020
This study aimed to investigatethe possible association of thiol/disulfidehomeostasiswith prostate-specific antigen levelsin prostate cancer patients and to compare the results with a normal healthy population ofa similar age group for the first time in ...
Ayse Ozdemir, Utku Donem Dilli, Salim Neselioglu, Ozcan Erel   +3 more
doaj   +1 more source

Polisitemi Veralı Hastalarda Dinamik Thiol/Disulfit Dengesi ve İskemi Modifiye Albumin Düzeyleri

Düzce Tıp Fakültesi Dergisi, 2021
Aim: Polycythemia vera is a chronic myeloproliferative disease characterized by increased red cell mass and JAK2 mutation positivity. Transformation to myelofibrosis and acute leukemia is possible in patients with polycythemia vera.
Özcan Erel, Hakan Basir, Mustafa Ilgan, Eyüp Naci Tiftik, Mahmut Bakır Koyuncu, Mehmet Ali Uçar, Aydan Akdeniz, Anıl Tombak, Salim Neşelioğlu   +8 more
doaj   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Thiol/disulfide homeostasis in asphalt workers

, 2016
The aim of this study was to investigate thiol/disulfide homeostasis in asphalt workers who are exposed to polycyclic aromatic hydrocarbons occupationally. The study was carried out in 34 nonsmoker asphalt workers.
Buyuksekerci, Murat, Bal, Ceylan, YILMAZ, FATMA MERİÇ, Gunduzoz, Meside, Eren, Funda, Neselioglu, Salim, YILMAZ, ÖMER HINÇ, Tutkun, Lutfiye   +7 more
core   +1 more source

Evaluation of Oxidative Stress with a New Method in Differentiated Thyroid Cancer Patients on Thyrotrophin Suppression Treatment

Endocrinology Research and Practice, 2021
Objective: Thyroid hormone suppression treatment (THST) is an essential modality in treating differentiated thyroid cancer (DTC). This study aimed to evaluate thiol/disulfide homeostasis with a new method in patients on THST, which causes a state of ...
Abbas Ali TAM, Didem ÖZDEMİR, Nagihan BEŞTEPE, Afra ALKAN, Sevgül FAKI, Özcan EREL, Reyhan ERSOY, Bekir ÇAKIR   +7 more
doaj   +1 more source

Intratumoral Hypoxia Triggers Mitochondrial BHLHE40 ROS Sensing Pathway to Promote Radioresistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Hypoxia triggers a dual mechanism for BHLHE40 upregulation: reactive oxygen species (ROS)‐dependent post‐translational modification and hypoxia‐inducible factor (HIF)‐dependent transcriptional activation. Under hypoxic conditions, mitochondrial BHLHE40 accumulates and senses ROS via cysteine thiol oxidation and disulfide‐linked homodimer formation ...
Jia Liu, Ziliang Nie, Xi Chen, Guangyu Ji, Yajing Zhang, Zhiqun Zhao, Yuhong Zhang, Xinlong Du, Zhenzhen Zhou, Jiayi Li, Yaozong Yang, Fengqi Sun, Zhibo Yan, Haiquan Lu   +13 more
wiley   +1 more source

Ddynamic thiol/disulfide homeostasis and oxidant status

, 2019
© 2019 Sciendo. All rights reserved.In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels.
Koca, Arzu Or, Altay, Mustafa, Neşelioǧlu, SALİM, Erel, ÖZCAN, Ateş, Ähsan, Daǧdeviren, Murat, Akkan, Tolga   +6 more
core   +1 more source

Assessment of thiol-disulfide and glutathione homeostasis after levothyroxine replacement in individuals with autoimmune or nonautoimmune hypothyroidism [PDF]

Archives of Endocrinology and Metabolism
Objective Thyroid hormones are known to affect the biosynthesis and degradation of antioxidant compounds, suggesting a possible link between hypothyroidism and oxidative stress.
Almila Senat, Osman Erinc, Soner Yesilyurt, Gamze Gok, Ozcan Erel   +4 more
doaj   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Thiol-disulfide homeostasis in irritable bowel syndrome

, 2023
OBJECTIVE: The etiopathogenesis and pathophysiological mechanism of irritable bowel syndrome (IBS) is not fully known. In this study, evaluating dynamic thiol-disulfide homeostasis (TDH) in patients with IBS was aimed. SUBJECTS AND METHODS: A total of 92
EREL, ÖZCAN, Uyanikoglu, A., Sari, S., Cindoglu, C., Ozkutlu, M.   +4 more
core   +1 more source