Results 1 to 10 of about 80,380 (385)

Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors

Plants, 2022
Naturally, thiophenes represent a small family of natural metabolites featured by one to five thiophene rings. Numerous plant species belonging to the family Asteraceae commonly produce thiophenes.
Sabrin R. M. Ibrahim, Abdelsattar M. Omar, Alaa A. Bagalagel, Reem M. Diri, Ahmad O. Noor, Diena M. Almasri, Shaimaa G. A. Mohamed, Gamal A. Mohamed   +7 more
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Direct dehydrocoupling facilitates efficient thiophene anchoring on silicon surfaces [PDF]

Nature Communications
Silicon is a cornerstone material in electronics and photovoltaics due to its abundance, tunable semiconducting properties, and chemical versatility. Direct anchoring of thiophenes, with their highly delocalized aromatic backbones, onto silicon surfaces ...
Jingpeng Li, Meiyu Zhang, Wenxuan Li, Zhongshu Li, Tingshun Zhu, Zhenyu Yang   +5 more
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Echinops as a Source of Bioactive Compounds—A Systematic Review [PDF]

Pharmaceuticals
Background: Echinops is a genus of spiny, herbaceous perennials in the Asteraceae family, known for its distinct morphology and broad pharmacological potential.
Simona Ivanova, Alexandra Ivanova, Mina Todorova, Vera Gledacheva, Stoyanka Nikolova   +4 more
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Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

Nature Communications, 2021
Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes.
Xingguang Li, Meng Duan, Peiyuan Yu, K. N. Houk, Jianwei Sun   +4 more
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Inhibition of human cytochromes P450 2A6 and 2A13 by flavonoids, acetylenic thiophenes and sesquiterpene lactones from Pluchea indica and Vernonia cinerea

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
The human liver cytochrome P450 (CYP) 2A6 and the respiratory CYP2A13 enzymes play role in nicotine metabolism and activation of tobacco-specific nitrosamine carcinogens.
Supattra Boonruang, Khanistha Prakobsri, Phisit Pouyfung, Ekaruth Srisook, Aruna Prasopthum, Pornpimol Rongnoparut, Songklod Sarapusit   +6 more
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Revisiting the Rearrangement of Dewar Thiophenes [PDF]

Molecules, 2020
The mechanism for the walk rearrangement in Dewar thiophenes has been clarified theoretically by studying the evolution of chemical bonds along the intrinsic reaction coordinates.
Sara Gómez, Edison Osorio, Eugenia Dzib, Rafael Islas, Albeiro Restrepo, Gabriel Merino   +5 more
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Silica gel-assisted synthesis of benzo[b]thiophenes from o-(alkylsulfanyl)(ethynyl)benzenes

Results in Chemistry, 2022
A variety of 2-substituted benzo[b]thiophenes were prepared from o-(alkylsulfanyl)(ethynyl)benzenes in the presence of silica gel under thermal conditions. Tertiary alkyl-substituted sulfanyl derivatives gave good results.
Kozo Toyota, Hiroki Tanaka, Taisei Hanagasaki   +2 more
doaj   +1 more source

The Ethnopharmacological Uses, Metabolite Diversity, and Bioactivity of Rhaponticum uniflorum (Leuzea uniflora): A Comprehensive Review

Biomolecules, 2022
Rhaponticum uniflorum (L.) DC. (syn. Leuzea uniflora (L.) Holub) is a plant species of the Compositae (Asteraceae) family that is widely used in Asian traditional medicines in China, Siberia, and Mongolia as an anti-inflammatory and stimulant remedy ...
Daniil N. Olennikov
doaj   +1 more source

Synthetic thiophenes induce chromosomal damage and trigger apoptosis in human cancer cell lines

European Journal of Medicinal Chemistry Reports, 2022
Thiophenes are heterocyclic compounds containing a five-membered ring with sulphur as the heteroatom. This class of substances has been shown to have several biological activities, including specific anti-proliferative effects against some cancer cell ...
Filipe N. Franco, Júlia T. Oliveira, Kimberly B. Tecchio, Flaviana A. Santos, Moacyr J.B.M. Rêgo, Francisco J.B. Mendonça-Júnior, Maira G.R. Pitta, Michelly C. Pereira, Rosy I.M.A. Ribeiro, Vanessa J.S.V. Santos, Fabio V. Santos   +10 more
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Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds

Molecules, 2022
Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists.
Sobhi M. Gomha, Sayed M. Riyadh, Bader Huwaimel, Mohie E. M. Zayed, Magda H. Abdellattif   +4 more
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