Results 1 to 10 of about 6,964 (243)

Nomenclature for alleles of the thiopurine methyltransferase gene. [PDF]

Pharmacogenet Genomics, 2013
The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice.
Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, Lennard L, Marinaki T, McLeod HL, Relling MV, Schaeffeler E, Schwab M, Weinshilboum R, Yeoh AE, McDonagh EM, Hebert JM, Klein TE, Coulthard SA.   +16 more
europepmc   +8 more sources

Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values [PDF]

BMC Research Notes, 2018
Objectives This study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate reference activity values for clinical use.
Ayorinde Adehin, Oluseye O. Bolaji
doaj   +2 more sources

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy [PDF]

Medical Sciences
The management of acute lymphoblastic leukemia (ALL), the most common pediatric malignancy, critically relies on thiopurine therapy, such as 6-mercaptopurine (6-MP), during the maintenance phase. However, significant inter-individual response variety and
Isfahan Shah Lubis, Kusnandar Anggadiredja, Aluicia Anita Artarini, Nur Melani Sari, Nur Suryawan, Zulfan Zazuli   +5 more
doaj   +2 more sources

The Utility of Thiopurine Methyltransferase Enzyme Testing in Inflammatory Bowel Disease [PDF]

Canadian Journal of Gastroenterology, 2013
OBJECTIVE: To assess the levels of red blood cell thiopurine methyltransferase (TPMT) in subjects with inflammatory bowel disease (IBD) and to determine how these levels impacted thiopurine dosing and leukopenia over the first six months of therapy.
Laura Chisick, Curtis Oleschuk, Charles N Bernstein   +2 more
doaj   +2 more sources

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia

Indian Journal of Medical and Paediatric Oncology, 2014
Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance phase of treatment. Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to
Vijay Gandhi Linga, Dorra Babu Patchva, Krishna Mohan Mallavarapu Venkata Tulasi, Krishnamani Iyer Kalpathi, Ashok Pillai, Sadashivudu Gundeti, Senthil J Rajappa, Raghunadharao Digumarti   +7 more
doaj   +2 more sources

A Rapid and Reliable Absorbance Assay to Identify Drug–Drug Interactions with Thiopurine Drugs [PDF]

Metabolites
Background: Thiopurine methyltransferase (TPMT) plays a crucial role in the detoxification of thiopurine drugs, including the antimetabolites azathioprine and 6-mercaptopurine (6-MP) used to treat autoimmune diseases and various cancers.
Drake A. Russell, Carson Stafford, Rheem A. Totah   +2 more
doaj   +2 more sources

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity. [PDF]

Cancer Chemother Pharmacol, 2017
Liu C, Janke LJ, Yang JJ, Evans WE, Schuetz JD, Relling MV.   +5 more
europepmc   +3 more sources

Clinical implication of thiopurine methyltransferase polymorphism in children with acute lymphoblastic leukemia: A preliminary Egyptian study. [PDF]

Indian J Med Paediatr Oncol, 2015
El-Rashedy FH, Ragab SM, Dawood AA, Temraz SA.   +3 more
europepmc   +3 more sources

Thiopurine methyltransferase activity in children with acute myeloid leukemia. [PDF]

Oncol Lett, 2018
Sobiak J, Skalska-Sadowska J, Chrzanowska M, Resztak M, Kołtan S, Wysocki M, Wachowiak J.   +6 more
europepmc   +3 more sources

Utilizing a user-centered approach to develop and assess pharmacogenomic clinical decision support for thiopurine methyltransferase. [PDF]

BMC Med Inform Decis Mak, 2019
Nguyen KA, Nguyen KA, Patel H, Haggstrom DA, Zillich AJ, Imperiale TF, Russ AL.   +6 more
europepmc   +2 more sources