Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values [PDF]
BMC Research Notes, 2018 Objectives This study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate reference activity values for clinical use.
Ayorinde Adehin, Oluseye O. Bolaji
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Thiopurine methyltransferase screening before azathioprine therapy [PDF]
British Journal of Ophthalmology, 2006 Azathioprine is used to treat various inflammatory eye conditions such as uveitis and dysthyroid orbitopathy. Despite good overall clinical response rates, particularly when used as steroid sparing agent, adverse effects such as severe myelosuppression can lead to early withdrawal in approximately a quarter of patients.1,2 Thiopurine methyltransferase
V Gauba +3 more
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Nomenclature for alleles of the thiopurine methyltransferase gene. [PDF]
Pharmacogenet Genomics, 2013 The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice.
Appell ML +16 more
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The Utility of Thiopurine Methyltransferase Enzyme Testing in Inflammatory Bowel Disease [PDF]
Canadian Journal of Gastroenterology, 2013 OBJECTIVE: To assess the levels of red blood cell thiopurine methyltransferase (TPMT) in subjects with inflammatory bowel disease (IBD) and to determine how these levels impacted thiopurine dosing and leukopenia over the first six months of therapy.
Laura Chisick +2 more
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NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy [PDF]
Medical SciencesThe management of acute lymphoblastic leukemia (ALL), the most common pediatric malignancy, critically relies on thiopurine therapy, such as 6-mercaptopurine (6-MP), during the maintenance phase. However, significant inter-individual response variety and
Isfahan Shah Lubis +5 more
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Thiopurine methyltransferase in acute lymphoblastic leukemia [PDF]
Blood, 2006 We recently reported that specific genetic polymorphisms, particularly polymorphisms in thymidylate synthase (TYMS) and glutathione S -transferase M1 (GSTM1) predicted the risk of relapse among children with acute lymphoblastic leukemia (ALL).[1][1] An accompanying commentary noted surprise that ...
Mary V. Relling +3 more
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Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia
Indian Journal of Medical and Paediatric Oncology, 2014 Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance phase of treatment. Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to
Vijay Gandhi Linga +7 more
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Thiopurine S -methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]
European Journal of Clinical Pharmacology, 2018 Objective: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs.
Fried, M. +5 more
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Thiopurine Methyltransferase Activity and Thiopurine Metabolites in Inflammatory Bowel Disease. [PDF]
Crohns Colitis 360, 2020 El-Matary W.
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A Rapid and Reliable Absorbance Assay to Identify Drug–Drug Interactions with Thiopurine Drugs [PDF]
MetabolitesBackground: Thiopurine methyltransferase (TPMT) plays a crucial role in the detoxification of thiopurine drugs, including the antimetabolites azathioprine and 6-mercaptopurine (6-MP) used to treat autoimmune diseases and various cancers.
Drake A. Russell +2 more
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