Results 121 to 130 of about 6,964 (243)

Should thiopurine methyltransferase (TPMT) activity be determined before prescribing azathioprine, mercaptopurine, or thioguanine? [PDF]

, 2015
Jennifer DiPiero, Kathryn Teng, J. Kevin Hicks   +2 more
openalex   +1 more source

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine

, 2021
Ahmed B. Bayoumy, Chris J. Mulder, A Loganayagam, Jeremy Sanderson, Simon Anderson, Paul J. Boekema, Luc J. J. Derijks, Azhar Ansari   +7 more
openalex   +1 more source

Farmakogenetiikka saapuu klinikkaan [PDF]

, 2016
English summaryPeer ...
Elenius, Klaus, Elenius, Varpu, Heliste, Juho, Niemi, Mikko   +3 more
core  

High-Throughput Genotyping of Thiopurine S-Methyltransferase by Denaturing HPLC [PDF]

, 2001
Elke Schaeffeler, Thomas Lang, Ulrich M. Zanger, Michel Eichelbaum, Matthias Schwab   +4 more
openalex   +1 more source

Thiopurine S-methyltransferase – An important intersection of drug-drug interactions in thiopurine treatment

Biomedicine & Pharmacotherapy
Understanding the molecular mechanisms of medicines is crucial for developing novel drugs, for repurposing existing medicines, and for predicting toxicities. Thiopurine S-methyltransferase (TPMT) serves as an exemplary case in personalized medicine, as its activity is influenced by genetic variants, co-factors, substrates, and inhibitors, which lead to
Dunja Urbančič, Marko Jukič, Alenka Šmid, Stanislav Gobec, Janez Jazbec, Irena Mlinarič-Raščan   +5 more
openaire   +2 more sources

P670 Identification of new genetic variants related to thiopurineinduced myelotoxicity in inflammatory bowel disease (IBD) patients with normal thiopurine s-methyltransferase (TPMT): a genome-wide association study [PDF]

, 2013
María Chaparro, Anna González‐Neira, Manuel Román, Guillermo Pita, Teresa Cabaleiro, D. Herrero, Belén Herráez, Ricardo Blanco, Carlos Taxonera, Pilar López Serrano, P Martínez Montiel, I. Vera, Fernando Bermejo, Antonio López-San Román, Francisco Abad‐Santos, Javier P. Gisbert   +15 more
openalex   +1 more source

Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia

Pakistan Journal of Medicine and Dentistry
Background: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza, Shamil Ashraf, Soofia Nigar, Itimad Abdelsalam Mohamed Ayed   +3 more
doaj   +1 more source

Elevated liver enzymes in inflammatory bowel disease: the role and safety of infliximab [PDF]

, 2016
BACKGROUND: Abnormal liver enzymes are frequently encountered in inflammatory bowel disease (IBD) patients. Infliximab has been implicated in inducing drug-induced liver injury, autoimmune hepatitis or reactivation of hepatitis B virus.
Burroughs, AK, Epstein, O, Hamilton, M, Manousou, P, Murray, C, O'Beirne, J, Parisi, I, Rossi, RE, Theocharidou, E, Tsochatzis, E   +9 more
core  

Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study

Haematologica
Allopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström, Riita Niinimäki, Johan Fredlund, Hartmut Vogt, Laura Korhonen, Anders Castor, Josefine Palle, Arja Harila, Magnus Borssén, Jonas Abrahamsson, Torben Ek   +10 more
doaj   +1 more source

Genotypic and phenotypic analysis of the thiopurine S-methyltransferase (TPMT) gene with clinical correlation

, 2013
Siu-ping Cheung
openalex   +1 more source