Results 41 to 50 of about 7,079 (242)
Personalized medicine : the impact on chemistry [PDF]
, 2010 An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew +3 more
core +1 more source
Frontiers in Pharmacology, 2022 Despite the growing number of new drugs approved for the treatment of inflammatory bowel disease (IBD), the long-term clinical use of thiopurine therapy and the well-known properties of conventional drugs including azathioprine have made their place in ...
Slavica Lazarević +5 more
doaj +1 more source
Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach
Mediators of Inflammation, 2015 Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model
Misbah Misdaq +4 more
doaj +1 more source
Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms? [PDF]
PLoS ONE, 2013 BACKGROUND AND AIMS: Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy.
Sofie Haglund +3 more
doaj +1 more source
Thiopurine methyltransferase phenotypes and genotypes in Brazilians [PDF]
Pharmacogenetics, 2003 The polymorphism of thiopurine methyltransferase (TPMT) was studied in 306 healthy Brazilians who were classed, on the basis of self-declared colour and ancestry, as Euro-derived (n = 81), Afro-derived (n = 18) or having interethnic admixture (n = 204).
Marcelo, Reis +2 more
openaire +2 more sources
Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID) [PDF]
Intestinal Research, 2015 Background/AimsFor decades, thiopurines have been the mainstay of inflammatory bowel disease (IBD) treatment and will play an important role in the future.
Kang-Moon Lee +5 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2022 Selenium is a chalcogen element that is essential in animals, but is highly toxic when ingested above the nutritional requirement. Selenite is used as a supplement in patients receiving total parenteral nutrition. However, the therapeutic and toxic doses
Yasunori Fukumoto +4 more
doaj +1 more source
Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?
Frontiers in Medicine, 2021 Thiopurines have been a cornerstone in the treatment of inflammatory bowel disease (IBD). Although they have been used for more than 50 years, there are still some unsolved issues about their efficacy and, also, some safety concerns, mainly the risk of ...
Carla J. Gargallo-Puyuelo +5 more
doaj +1 more source
Very important pharmacogene summary: thiopurine S-methyltransferase [PDF]
Pharmacogenetics and Genomics, 2010 Thiopurine S-methyltransferase (TPMT, S-adenosyl-L-methionine : thiopurine S-methyltransferase; EC 2.1.1.67) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and azathioprine as well as other aromatic and heterocyclic sulfhydryl compounds [1,2].Weinshilboum and ...
Liewei, Wang +6 more
openaire +2 more sources
Role of Oxidative Stress Mediated by Glutathione-S-transferase in Thiopurines' Toxic Effects [PDF]
, 2015 Azathioprine (AZA), 6-mercaptopurine (6-MP), and 6-thioguanine (6-TG) are antimetabolite drugs, widely used as immunosuppressants and anticancer agents.
De Iudicibus, Sara +9 more
core +1 more source