Results 81 to 90 of about 7,079 (242)

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 3, Page 765-815, September 2025.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S. Hudson, Séamus Hussey, Johan van Limbergen, Erasmo Miele, Lorenzo Norsa, Ola Olén, Gianluca Pellino, Patrick van Rheenen, Lissy de Ridder, Richard K. Russell, Dror S. Shouval, Eunice Trindade, Dan Turner, David C. Wilson, Anat Yerushalmy Feler, Amit Assa   +24 more
wiley   +1 more source

Does adult ADHD interact with COMT val 158 met genotype to influence working memory performance? [PDF]

, 2016
Peer ...
Biehl, Stefanie C, Deckert, Jürgen, Gschwendtner, Kathrin M, Guhn, Anne, Herrmann, Martin J, Heupel, Julia, Jacob, Christian P., Muller, Laura D, Reichert, Susanne, Reif, Andreas   +9 more
core   +1 more source

COLLAB: A Global Survey of Clinical and Laboratory Assessment in Alopecia Areata by Hair Specialists

JEADV Clinical Practice, Volume 4, Issue 4, Page 811-820, September 2025.
Guidelines for alopecia areata recommend that baseline investigations are unnecessary, but is this standard practice among hair loss experts worldwide? This global study showed high rates of laboratory testing of patients with alopecia areata, particularly related to autoimmune co‐morbidities.
Cathal O'Connor, Aoife Boyle, Leila Asfour, Bevin Bhoyrul, Laita Bokhari, George Cotsarelis, Chantal Cotter, Brittany Craiglow, Lara Cutlar, Rachita Dhurat, Ncoza Dlova, Isabella Doche, Jeff Donovan, Aaron M. Drucker, Samantha Eisman, Daniel Fernandes Melo, Matthew J. Harries, Maria Hordinsky, Ahmed Kazmi, Brett King, Antonios Kolios, Nekma Meah, Paradi Mirmirani, Arash Mostaghimi, Manabu Ohyama, Yuliya Ovcharenko, Rodrigo Pirmez, Bianca Maria Piraccini, Lidia Rudnicka, David Saceda‐Corralo, Jerry Shapiro, Cathryn Sibbald, Rod Sinclair, Blake R. C. Smith, Michela Starace, Sergio Vaño‐Galván, Wei Liang Koh, Katherine York, Ian McDonald, Dmitri Wall   +39 more
wiley   +1 more source

P791 Up to one third of rapid thiopurine-S-methyltransferase metabolizers manifest clinical and/or laboratory azathioprine side effects: A single centre experience [PDF]

, 2023
N E Lababidi, F Pavel
openalex   +1 more source

Methyltransferases from Ruta graveolens L.: Molecular Biology and Biochemistry [PDF]

, 2005
The common rue, Ruta graveolens L., is an aromatic plant. It contains acridone alkaloids, furoquinolines, coumarins, and numerous volatile compounds with antimicrobial and allelopathic activity.
Burga, Laura, Matern, Ulrich (Prof. Dr.)
core   +1 more source

AlphaFold modeling uncovers global structural features of class I and class II fungal hydrophobins

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Hydrophobins are a family of small fungal proteins that self‐assemble at hydrophobic–hydrophilic interfaces. Hydrophobins not only play crucial roles in filamentous fungal growth and development but also have attracted substantial attention due to their unique material properties.
Li‐Yen Yang, Daniel J. Hicks, Paul S. Russo, Andrew C. McShan   +3 more
wiley   +1 more source

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response

Pharmacogenomics and Personalized Medicine, 2017
Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
doaj  

Importance of genotyping of Thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2008
INTRODUCTION Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood.
Dokmanović Lidija, Janić Dragana, Krstovski Nada, Zukić Branka, Tošić Nataša, Pavlović Sonja   +5 more
doaj   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]

, 2018
Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay, Eadon, Michael T., Gao, Hongyu, Gufford, Brandon T., Lin, Hai, Liu, Yunlong, Robarge, Jason D., Skaar, Todd C.   +7 more
core   +1 more source