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Kinetics of electron transfer from thioredoxin reductase to thioredoxin
Biochemistry, 1991The reduction of Escherichia coli thioredoxin by thioredoxin reductase was studied by stopped-flow spectrophotometry. The reaction showed no dependence on thioredoxin concentration, indicating that complex formation was rapid and occurred during the dead time of the instrument.
J A, Navarro +5 more
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Cytosolic, Mitochondrial Thioredoxins and Thioredoxin Reductases in Arabidopsis Thaliana
Photosynthesis Research, 2004Thioredoxins, by reducing disulfide bridges are one of the main participants that regulate cellular redox balance. In plants, the thioredoxin system is particularly complex. The most well-known thioredoxins are the chloroplastic ones, that participate in the regulation of enzymatic activities during the transition between light and dark phases.
Bréhélin, Claire +4 more
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Rat liver thioredoxin and thioredoxin reductase: purification and characterization
Biochemistry, 1982A reproducible scheme has been developed for the preparation of rat liver thioredoxin and thioredoxin reductase (EC 1.6.4.5) by using assays based on reduction of insulin and 5,5'-dithiobis(2-nitrobenzoic acid), respectively. Both proteins were purified to homogeneity, as judged from polyacrylamide gel electrophoresis.
M, Luthman, A, Holmgren
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Thioredoxin and NADP-thioredoxin reductase from cultured carrot cells
Planta, 1987Dark-grown carrot (Daucus carota L.) tissue cultures were found to contain both protein components of the NADP/thioredoxin system--NADP-thioredoxin reductase and the thioredoxin characteristic of heterotrophic systems, thioredoxin h. Thioredoxin h was purified to apparent homogeneity and, like typical bacterial counterparts, was a 12-kdalton (kDa ...
T C, Johnson +3 more
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Studies toward Novel Peptidomimetic Inhibitors of Thioredoxin–Thioredoxin Reductase System
Journal of Medicinal Chemistry, 2011Thioredoxins (Trx) are ubiquitous multifunctional low-molecular weight proteins that together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis in NADPH-dependent reactions. An increasing number of data reveal that the Trx-TrxR system is an attractive target for anticancer therapies.
Szymon, Kłossowski +6 more
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Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase–Thioredoxin Complex
Journal of Molecular Biology, 2013Over the last decades, malaria parasites have been rapidly developing resistance against antimalarial drugs, which underlines the need for novel drug targets. Thioredoxin reductase (TrxR) is crucially involved in redox homeostasis and essential for Plasmodium falciparum. Here, we report the first crystal structure of P.
Fritz-Wolf, K. +6 more
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Preparation and assay of mammalian thioredoxin and thioredoxin reductase
1999Publisher Summary This chapter describes the preparation and assay of mammalian thioredoxin and thioredoxin reductase (TrxR). The amino acid sequences of mammalian TrxR revealed a strikingly high homology to glutathione reductase. 14,19 The conserved features of all the structural components of glutathione reductase are preserved in mammalian TrxR ...
E S, Arnér, L, Zhong, A, Holmgren
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1997
Abstract Mammalian thioredoxin has been purified from several sources including rat Novikoff hepatoma, calf liver, rat liver, rabbit bone marrow, human placenta (Holmgren, 1985; Holmgren, Bjornstedt, 1995). A protein that was purified from the conditioned medium of human T cell lymphotropic virus type-l (HTLV-l)-trans-formed T cells ...
H Nakamura, M Bjornstedt, A Holmgren
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Abstract Mammalian thioredoxin has been purified from several sources including rat Novikoff hepatoma, calf liver, rat liver, rabbit bone marrow, human placenta (Holmgren, 1985; Holmgren, Bjornstedt, 1995). A protein that was purified from the conditioned medium of human T cell lymphotropic virus type-l (HTLV-l)-trans-formed T cells ...
H Nakamura, M Bjornstedt, A Holmgren
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Nihon rinsho. Japanese journal of clinical medicine, 2005
Aoi, Son, Junji, Yodoi, Hajime, Nakamura
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Aoi, Son, Junji, Yodoi, Hajime, Nakamura
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Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome
Nature, 2023Jiro Kitaura +2 more
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