Results 91 to 100 of about 31,059 (323)

Molecular characterisation of the thioredoxins in the parasitic nematode haemonchus contortus [PDF]

, 2008
University of Technology, Sydney. Faculty of Science.Thioredoxins are a family of small proteins conserved through evolution, essential for cellular homeostasis.
Sotirchos, Irene M
core  

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Metabolic Dependencies in Pancreatic Cancer. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R., Vaziri-Gohar, Ali, Winter, Jordan M., Zarei, Mahsa   +3 more
core   +1 more source

Correlation between Low Temperature Adaptation and Oxidative Stress in Saccharomyces cerevisiae [PDF]

, 2016
Many factors, such as must composition, juice clarification, fermentation temperature, or inoculated yeast strain, strongly affect the alcoholic fermentation and aromatic profile of wine.
García Ríos, Estéfani, Guillamón, José Manuel, Ramos Alonso, Lucía   +2 more
core   +2 more sources

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Stress-triggered redox signalling: What’s in pROSpect? [PDF]

, 2016
Reactive oxygen species (ROS) have a profound influence on almost every aspect of plant biology. Here, we emphasize the fundamental, intimate relationships between light-driven reductant formation, ROS, and oxidative stress, together with compartment ...
Aller, Awad, Ball, Barranco-Medina, Bartoli, Belin, Benina, Birk, Buchanan, Cosio, Costa, Delaunay, Dietz, Dietz, Dominguez-Solis, Esposito-Rodriguez, Farmer, Foyer, Foyer, Foyer, Frottin, Gibbs, Gomez, Gomez-Cabrera, Grzam, Gutscher, Han, Han, Hatem, Hebelstrup, Hirasawa, Jiang, Järvi, Kieselbach, Kolbe, Koornneef, Kovács-Bogdán, König, Laloi, Marchal, Maughan, Meitha, Mhamdi, Mhamdi, Miao, Mittler, Miyaji, Mohyeldin, Mou, Møller, Møller, Møller, Noctor, Noctor, Noctor, Noctor, Nunn, O'Brien, Ohkamu-Ohtsu, Park, Parsons, Perez-Martin, Pignocchi, Queval, Queval, Queval, Radak, Radak, Rahantaniaina, Ramel, Rasmusson, Rautenkranz, Reichheld, Ruban, Río, Sandermann, Schafer, Scheibe, Schnaubelt, Schwarzländer, Sharkey, Strawn, Tada, Vainonen, Vanacker, Veljovic-Jovanovic, Vestergaard, Weits, Xia, Xiao, Zechmann, Zhang   +91 more
core   +2 more sources

Chaperone-like properties of tobacco plastid thioredoxins f and m

Journal of Experimental Botany, 2011
Thioredoxins (Trxs) are ubiquitous disulphide reductases that play important roles in the redox regulation of many cellular processes. However, some redox-independent functions, such as chaperone activity, have also been attributed to Trxs in recent ...
Ruth Sanz-Barrio, A. Fernández-San Millán, J. Carballeda, P. Corral-Martínez, J. M. Seguí-Simarro, Inmaculada Farran   +5 more
semanticscholar   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Thioredoxin H (TrxH) contributes to adversity adaptation and pathogenicity of Edwardsiella piscicida

Veterinary Research, 2019
Thioredoxins (Trxs) play an important role in defending against oxidative stress and keeping disulfide bonding correct to maintain protein function. Edwardsiella piscicida, a severe fish pathogen, has been shown to encode several thioredoxins including ...
Bi-ying Wang, Hui-qin Huang, Shuang Li, Ping Tang, Hao-fu Dai, Jian-an Xian, Dong-mei Sun, Yong-hua Hu   +7 more
doaj   +1 more source

Thioredoxin and evolution [PDF]

Comparisons of primary structure have revealed significant homology between the m type thioredoxins of chloroplasts and the thioredoxins from a variety of bacteria.
Buchanan, B. B.
core   +1 more source