Results 81 to 90 of about 8,012 (300)

Evolutionary modes in protein observable space: the case of Thioredoxins [PDF]

, 2019
In this article, we investigated the structural and dynamical evolutionary behaviour of a set of ten thioredoxin proteins as formed by three extant forms and seven resurrected ones in laboratory.
Amadei, Andrea, Del Galdo S., D'Abramo, Marco, Del Galdo, Sara, Alba, Josephine, Alba J., Amadei A., D’Abramo, Marco, D'Abramo M.   +8 more
core   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Thioredoxin H (TrxH) contributes to adversity adaptation and pathogenicity of Edwardsiella piscicida

Veterinary Research, 2019
Thioredoxins (Trxs) play an important role in defending against oxidative stress and keeping disulfide bonding correct to maintain protein function. Edwardsiella piscicida, a severe fish pathogen, has been shown to encode several thioredoxins including ...
Bi-ying Wang, Hui-qin Huang, Shuang Li, Ping Tang, Hao-fu Dai, Jian-an Xian, Dong-mei Sun, Yong-hua Hu   +7 more
doaj   +1 more source

Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides

, 2002
Glutaredoxins and thioredoxins are highly conserved, small, heat-stable oxidoreductases. The yeast Saccharomyces cerevisiae contains two gene pairs encoding cytoplasmic glutaredoxins (GRX1, GRX2) and thioredoxins (TRX1, TRX2), and we have used multiple ...
Garrido, Ester Ocón, Ester Ocón Garrido, Grant, Chris M., Chris M. Grant   +3 more
core   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Functional characterisation of plant cytosolic thioredoxins. [PDF]

, 2010
Thioredoxins are small, ubiquitous, disulfide oxidoreductase proteins characterised by a conserved dicysteine active site. Within the cell, they are believed to maintain the redox environment and participate in a broad range of biochemical processes ...
Dolman, Fleur Catherine
core  

Plot of denaturation temperature versus environmental temperature including modern thioredoxins (red), resurrected ancestral thioredoxins (blue) and resurrected ancestral elongation factors (yellow).

, 2016
Elongation factor data conform approximately to the continuous line representing Tm = TENV. Modern and ancestral thioredoxins describe a general trend that conforms a common linear dependence at about 50 degrees above the Tm = TENV line (the continuous ...
Eric A. Gaucher (358033), Beatriz Ibarra-Molero (158272), M. Luisa Romero-Romero (347004), Valeria A. Risso (205127), Sergio Martinez-Rodriguez (2814223), Jose M. Sanchez-Ruiz (118283)   +5 more
core   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Overexpression of chloroplast NADPH-dependent thioredoxin reductase in Arabidopsis enhances leaf growth and elucidates in-vivo function of reductase and thioredoxin domains

Frontiers in Plant Science, 2013
Plant chloroplasts have versatile thioredoxin systems including two thioredoxin reductases and multiple types of thioredoxins. Plastid-localized NADPH-dependent thioredoxin reductase (NTRC) contains both reductase (NTRd) and thioredoxin (TRXd) domains in
Jouni eToivola, Lauri eNikkanen, Käthe M. Dahlström, Tiina A. Salminen, Anna eLepistö, Florence eVignols, Eevi eRintamäki   +6 more
doaj   +1 more source

Wine Yeast Peroxiredoxin TSA1 Plays a Role in Growth, Stress Response and Trehalose Metabolism in Biomass Propagation

Microorganisms, 2020
Peroxiredoxins are a family of peroxide-degrading enzymes for challenging oxidative stress. They receive their reducing power from redox-controlling proteins called thioredoxins, and these, in turn, from thioredoxin reductase.
Víctor Garrigós, Cecilia Picazo, Emilia Matallana, Agustín Aranda   +3 more
doaj   +1 more source