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Fish Peroxiredoxins and Their Role in Immunity [PDF]
Biology, 2015 Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The
Yulema Valero +2 more
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The Human 2-Cys Peroxiredoxins form Widespread, Cysteine-Dependent- and Isoform-Specific Protein-Protein Interactions [PDF]
Antioxidants, 2021 Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-translational modification triggered by H2O2 acting as a second messenger.
Loes van Dam +6 more
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Peroxiredoxins—The Underrated Actors during Virus-Induced Oxidative Stress
Antioxidants, 2021 Enhanced production of reactive oxygen species (ROS) triggered by various stimuli, including viral infections, has attributed much attention in the past years. It has been shown that different viruses that cause acute or chronic diseases induce oxidative
Inna L. Karpenko +4 more
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Peroxiredoxins in Cancer and Response to Radiation Therapies
Antioxidants, 2019 Peroxiredoxins have a long-established cellular function as regulators of redox metabolism by catalyzing the reduction of peroxides (e.g., H2O2, lipid peroxides) with high catalytic efficiency.
Tom E. Forshaw +8 more
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Redox Biology, 2023 In the cytosol of human cells under low oxidative loads, hydrogen peroxide is confined to microdomains around its supply sites, due to its fast consumption by peroxiredoxins.
Armindo Salvador
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Peroxiredoxins as Potential Targets for Cardiovascular Disease
Antioxidants, 2021 Increased oxidative stress (OS) is considered a common etiology in the pathogenesis of cardiovascular disease (CVD). Therefore, the precise regulation of reactive oxygen species (ROS) in cardiovascular cells is essential to maintain normal physiological ...
Se-Jin Jeong +2 more
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Redox Regulation of PTEN by Peroxiredoxins
Antioxidants, 2021 Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is known as a tumor suppressor gene that is frequently mutated in numerous human cancers and inherited syndromes.
Thang Nguyen Huu +2 more
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New insights into the roles of peroxiredoxins in cancer
Biomedicine and Pharmacotherapy, 2023 Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of antioxidant expression levels.
Yan Liu, P. Wang, Weina Hu, Dawei Chen
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Oxidative stress in Prymnesium parvum: cellular mechanisms, redox regulation, and implications for harmful algal bloom management [PDF]
Frontiers in Plant SciencePrymnesium parvum is a mixotrophic haptophyte known for its harmful algal blooms (HABs), which are driven by its ability to adapt to fluctuating environmental conditions, particularly osmotic and oxidative stress.
Tomasz Krupnik
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Interplay Between Mitochondrial Peroxiredoxins and ROS in Cancer Development and Progression
International Journal of Molecular Sciences, 2019 Mitochondria are multifunctional cellular organelles that are major producers of reactive oxygen species (ROS) in eukaryotes; to maintain the redox balance, they are supplemented with different ROS scavengers, including mitochondrial peroxiredoxins ...
Tayaba Ismail +2 more
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