Results 21 to 30 of about 9,422 (217)
Peroxiredoxins in Neurodegenerative Diseases [PDF]
Antioxidants, 2020 Substantial evidence indicates that oxidative/nitrosative stress contributes to the neurodegenerative diseases. Peroxiredoxins (PRDXs) are one of the enzymatic antioxidant mechanisms neutralizing reactive oxygen/nitrogen species. Since mammalian PRDXs were identified 30 years ago, their significance was long overshadowed by the other well-studied ROS ...
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Biobanking efforts and new advances in male fertility preservation for rare and endangered species
Asian Journal of Andrology, 2015 Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials (Genome Resource Banks).
Pierre Comizzoli
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The Peroxiredoxin Repair Proteins [PDF]
, 2007 Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to
Thomas J, Jönsson, W Todd, Lowther
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Antioxidants, 2018 Colorectal cancer (CRC) is the third most common cancer in the Western world, with one-third of cases located in the rectum. Preoperative radiotherapy is the standard of care for many patients with rectal cancer but has a highly variable response rate ...
Jesse Fischer +3 more
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Measurement of Peroxiredoxin Activity [PDF]
Current Protocols in Toxicology, 2011 AbstractPeroxiredoxins are cysteine‐dependent peroxidases that react with hydrogen peroxide, larger hydroperoxide substrates, and peroxynitrite. Protocols are provided to measure Prx activity with peroxide by (1) a coupled reaction with NADPH, thioredoxin reductase, and thioredoxin, (2) the direct monitoring of thioredoxin oxidation, (3) competition ...
Kimberly J, Nelson, Derek, Parsonage
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Urate hydroperoxide oxidizes human peroxiredoxin 1 and peroxiredoxin 2 [PDF]
Journal of Biological Chemistry, 2017 Urate hydroperoxide is a product of the oxidation of uric acid by inflammatory heme peroxidases. The formation of urate hydroperoxide might be a key event in vascular inflammation, where there is large amount of uric acid and inflammatory peroxidases.
Larissa A C, Carvalho +7 more
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Ezrin: a regulator of actin microfilaments in cell junctions of the rat testis
Asian Journal of Andrology, 2015 Ezrin, radixin, moesin and merlin (ERM) proteins are highly homologous actin-binding proteins that share extensive sequence similarity with each other.
N Ece Gungor-Ordueri +2 more
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Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?
Asian Journal of Andrology, 2015 This chapter explores the possibility that capacitation and apoptosis are linked processes joined by their common dependence on the continued generation of reactive oxygen species (ROS).
Robert J Aitken +2 more
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Peroxiredoxins and their expression in ependymomas
Journal of Clinical Pathology, 2012 AimsPeroxiredoxins I–VI (Prxs) have recently been shown to have a role in the tumorigenesis of astrocytic brain tumours. In some tumour types they are associated with Nrf2 (transcription factor NF-E2-related factor), a sensor of oxidative stress, and DJ-1 (also known as PARK7), a protein known to stabilise Nrf2.MethodsWe investigated the ...
Kinnula Vuokko L. +8 more
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The role of peroxiredoxins in cancer
Molecular and Clinical Oncology, 2017 Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite. They are highly involved in the control of various physiological functions, including cell growth, differentiation, apoptosis, embryonic development, lipid ...
NICOLUSSI, Arianna +4 more
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