Results 21 to 30 of about 19,535 (281)

Knockout Mouse Models for Peroxiredoxins

Antioxidants, 2020
Peroxiredoxins (PRDXs) are members of a highly conserved peroxidase family and maintain intracellular reactive oxygen species (ROS) homeostasis. The family members are expressed in most organisms and involved in various biological processes, such as ...
Y. J. Lee
semanticscholar   +2 more sources

Insect Peroxiredoxins: A Comprehensive Review of Their Classification, Distribution, Structural Features, Expression Profiles and Physiological Functions [PDF]

Insects
With the development of technology, an increasing amount of literature regarding the expression profiles and physiological functions of Prxs has been published. Despite this growing interest, there is currently no systematic review of expression profiles
Li Yang, Shaohua Lu, Yujie Lu, Mingshun Chen, Sufen Cui   +4 more
doaj   +2 more sources

The Role of Peroxiredoxins in the Regulation of Sepsis

Antioxidants, 2022
Oxidative stress, a result of a disturbance in redox homeostasis, is considered to be one of the main aggravating events in the pathogenesis of immune disorders.
Toshihiko Aki, Unuma Kana, Uemura Koichi   +2 more
exaly   +3 more sources

Piecing Together How Peroxiredoxins Maintain Genomic Stability

Antioxidants, 2018
Peroxiredoxins, a highly conserved family of thiol oxidoreductases, play a key role in oxidant detoxification by partnering with the thioredoxin system to protect against oxidative stress.
J. D. West, Trevor J. Roston, J. B. David, Kristin M. Allan, M. Loberg   +4 more
semanticscholar   +3 more sources

Peroxiredoxins in colorectal neoplasms [PDF]

Histology and histopathology, 2010
Peroxiredoxins (Prxs) are novel group proteins with efficient antioxidant capacity, and some of them also have effects on cell proliferation, differentiation, apoptosis, and chemotherapy and radiotherapy resistance.
Fu, X.Z., Wang, X.H., Wu, X.Y.
core   +4 more sources

Characterization of the Biochemical Recurrence Prediction Ability and Progression Correlation of Peroxiredoxins Family in Prostate Cancer Based on Integrating Single‐Cell RNA‐Seq and Bulk RNA‐Seq Cohorts [PDF]

Cancer Medicine
Introduction The peroxiredoxins (PRDXs) family plays a crucial role in balancing reactive oxygen species (ROS) levels in tumor cells. However, its potential role in prognosis and therapy response of prostate cancer (PCa) remains unknown.
Shan Tang, Jinchuang Li, Weicheng Tian, Yuanfa Feng, Yulin Deng, Zeheng Tan, Zhaodong Han, Huichan He, Yongding Wu, Chuyang Huang, Keping Ning, Feng Liu, Hongwei Luo, Shanghua Cai, Jianheng Ye, Weide Zhong   +15 more
doaj   +2 more sources

Peroxiredoxins in gametogenesis and embryo development.

, 2007
Reactive oxygen species have been implicated in gametogenesis and embryo development in animals. As peroxiredoxins are now recognized as important protective antioxidant enzymes as well as modulators of hydrogen peroxide-mediated signaling, we addressed ...
Knoops, Bernard, Donnay, Isabelle
core   +3 more sources

Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

Acta Pharmaceutica Sinica B, 2021
Ferroptosis is a form of regulated cell death, characterized by excessive membrane lipid peroxidation in an iron- and ROS-dependent manner. Celastrol, a natural bioactive triterpenoid extracted from Tripterygium wilfordii, shows effective anti-fibrotic ...
Piao Luo, Dandan Liu, Qian Zhang, Fan Yang, Y. Wong, Fei Xia, Junzhe Zhang, Jiayun Chen, Yajing Tian, Chuanbin Yang, Lingyun Dai, Han-Ming Shen, Jigang Wang   +12 more
semanticscholar   +1 more source

Review of Postmortem Protein Oxidation in Skeletal Muscle and the Role of the Peroxiredoxin Family of Endogenous Antioxidants

Meat and Muscle Biology, 2023
The development of fresh meat quality is dictated by biochemical changes during the perimortem and postmortem period. Lipid and protein oxidation in postmortem skeletal muscle and meat products is detrimental to product quality.
Brian M Patterson, Elisabeth J. Huff-Lonergan, Logan G Johnson, Steven M. Lonergan   +3 more
doaj   +2 more sources

Peroxiredoxins wear many hats: Factors that fashion their peroxide sensing personalities

Redox Biology, 2021
Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein interactions. Understanding the role of the multiple structural and post-translational modification (PTM) layers that tunes the peroxiredoxin specificities is still a ...
Jesalyn A. Bolduc, K. Koruza, Ting Luo, Julia Malo Pueyo, Trung Nghia Vo, Daria Ezeriņa, J. Messens   +6 more
semanticscholar   +1 more source