Results 11 to 20 of about 9,422 (217)
Peroxiredoxins in Parasites [PDF]
Antioxidants & Redox Signaling, 2012 Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens.Plasmodial and kinetoplastid Prx systems are the ...
Michael C, Gretes +2 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Insight into metabolic sensors of nitrosative stress protection in Phytophthora infestans
Frontiers in Plant Science, 2023 Phytophthora infestans, a representative of phytopathogenic oomycetes, have been proven to cope with redundant sources of internal and host-derived reactive nitrogen species (RNS).
Joanna Gajewska +7 more
doaj +1 more source
Peroxiredoxins in Cancer and Response to Radiation Therapies
Antioxidants, 2019 Peroxiredoxins have a long-established cellular function as regulators of redox metabolism by catalyzing the reduction of peroxides (e.g., H2O2, lipid peroxides) with high catalytic efficiency.
Tom E. Forshaw +8 more
doaj +1 more source
Cancer-Associated Function of 2-Cys Peroxiredoxin Subtypes as a Survival Gatekeeper
Antioxidants, 2018 Cancer cells are abnormal cells that do not comply with tissue homeostasis but undergo uncontrolled proliferation. Such abnormality is driven mostly by somatic mutations on oncogenes and tumor suppressors.
Sang Won Kang +2 more
doaj +1 more source
Peroxiredoxins—The Underrated Actors during Virus-Induced Oxidative Stress
Antioxidants, 2021 Enhanced production of reactive oxygen species (ROS) triggered by various stimuli, including viral infections, has attributed much attention in the past years. It has been shown that different viruses that cause acute or chronic diseases induce oxidative
Inna L. Karpenko +4 more
doaj +1 more source
IUCrJ, 2018 Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidase enzymes. Recently, a new type of Prx, VvPrx3, was identified in the pathogenic bacterium Vibrio vulnificus as being important for survival in macrophages.
Jinsook Ahn +7 more
doaj +1 more source
2-Cys Peroxiredoxins: Emerging Hubs Determining Redox Dependency of Mammalian Signaling Networks
International Journal of Cell Biology, 2014 Mammalian cells have a well-defined set of antioxidant enzymes, which includes superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins.
Jinah Park +3 more
doaj +1 more source
Redox Signaling from Mitochondria: Signal Propagation and Its Targets
Biomolecules, 2020 Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling.
Petr Ježek +2 more
doaj +1 more source