Results 31 to 40 of about 19,535 (281)

Pitfalls of Mitochondrial Redox Signaling Research

Antioxidants, 2023
Redox signaling from mitochondria (mt) to the cytosol and plasma membrane (PM) has been scarcely reported, such as in the case of hypoxic cell adaptation or (2-oxo-) 2-keto-isocaproate (KIC) β-like-oxidation stimulating insulin secretion in pancreatic β ...
Petr Ježek
doaj   +1 more source

Peroxiredoxins in Parasites [PDF]

Antioxidants & Redox Signaling, 2012
Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens.Plasmodial and kinetoplastid Prx systems are the ...
Michael C, Gretes, Leslie B, Poole, P Andrew, Karplus   +2 more
openaire   +2 more sources

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

PRDX1 Influences The Occurrence and Progression of Liver Cancer by Inhibiting Mitochondrial Apoptosis Pathway [PDF]

Cell Journal, 2022
ObjectiveThe aim of this study is to elucidate the role of PRDX1 in hepatocellular carcinoma using hepatomacells.Materials and MethodsIn this experimental study, we elucidated role of PRDX1, using hepatoma cell lines.ResultsPRDX1 was upregulated in ...
Hong-hua Sun, Yang-long Li, Hao Jiang, Xiang-hua Yin, Xing-lin Jin   +4 more
doaj   +1 more source

Insight into metabolic sensors of nitrosative stress protection in Phytophthora infestans

Frontiers in Plant Science, 2023
Phytophthora infestans, a representative of phytopathogenic oomycetes, have been proven to cope with redundant sources of internal and host-derived reactive nitrogen species (RNS).
Joanna Gajewska, Jolanta Floryszak-Wieczorek, Arkadiusz Kosmala, Dawid Perlikowski, Marek Żywicki, Ewa Sobieszczuk-Nowicka, Howard S. Judelson, Magdalena Arasimowicz-Jelonek   +7 more
doaj   +1 more source

The Role of Hydrogen Peroxide and Peroxiredoxins throughout the Cell Cycle

Antioxidants, 2020
Hydrogen peroxide (H2O2) is an oxidizing agent that induces cellular damage at inappropriate concentrations and gives rise to an arrest during cell cycle progression, causing cell death.
Sukyeong Heo, Suree Kim, D. Kang
semanticscholar   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import. [PDF]

Protein Sci
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Hasberg L, Lauterbach VK, Ochsenreiter T, Riemer J.   +3 more
europepmc   +2 more sources

Single molecule mass photometry reveals the dynamic oligomerization of human and plant peroxiredoxins

iScience, 2021
Summary Protein oligomerization is central to biological function and regulation, yet its experimental quantification and measurement of dynamic transitions in solution remain challenging.
Michael Liebthal, Manish S Kushwah, P. Kukura, K. Dietz   +3 more
semanticscholar   +1 more source

Cancer-Associated Function of 2-Cys Peroxiredoxin Subtypes as a Survival Gatekeeper

Antioxidants, 2018
Cancer cells are abnormal cells that do not comply with tissue homeostasis but undergo uncontrolled proliferation. Such abnormality is driven mostly by somatic mutations on oncogenes and tumor suppressors.
Sang Won Kang, Sunmi Lee, Joanna H. S. Lee   +2 more
doaj   +1 more source