Results 61 to 70 of about 8,012 (300)

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Functional studies of multiple thioredoxins from Mycobacterium tuberculosis

, 2008
Cytoplasmic protein reduction via generalized thiol/disulfide exchange reactions and maintenance of cellular redox homeostasis is mediated by the thioredoxin superfamily of proteins.
Tyagi, Anil K., Mande, Shekhar C., Khare, Garima, Akif, Mohd, Sardesai, Abhijit A.   +4 more
core   +1 more source

Behavioral mechanisms of mammalian sperm guidance

Asian Journal of Andrology, 2015
In mammals, sperm guidance in the oviduct appears essential for successful sperm arrival at the oocyte. Hitherto, three different potential sperm guidance mechanisms have been recognized: thermotaxis, rheotaxis, and chemotaxis, each of them using ...
Serafín Pérez Cerezales, Sergii Boryshpolets, Michael Eisenbach   +2 more
doaj   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

A comparative evaluation of semen parameters in pre- and post-Hurricane Katrina human population

Asian Journal of Andrology, 2015
A natural disaster leading to accumulation of environmental contaminants may have substantial effects on the male reproductive system. Our aim was to compare and assess semen parameters in a normospermic population residing in the Southern Louisiana, USA
Caner Baran, Wayne J Hellstrom, Suresh C Sikka   +2 more
doaj   +1 more source

Redox signals and oxidative stress in the control of mitochondrial protein import. [PDF]

Protein Sci
Abstract Mitochondrial protein import is essential for organelle biogenesis and cellular homeostasis. It operates in an environment that is intrinsically shaped by redox chemistry. Mitochondria are major sources of reactive oxygen species (ROS), which arise as by‐products of oxidative phosphorylation. Cells therefore maintain sophisticated ROS‐handling
Hasberg L, Lauterbach VK, Ochsenreiter T, Riemer J.   +3 more
europepmc   +2 more sources

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Thioredoxin–thioredoxin reductase – a system that has come of age [PDF]

European Journal of Biochemistry, 2000
‹12 000 protein having a redoxactive disulfide; thioredoxin was the name assigned to thisprotein [4]. It was shown that thioredoxin was reduced bythioredoxin reductase in a NADPH-dependent reaction and thatin its dithiol form, thioredoxin served as the reductant ofribonucleotides via a ribonucleotide reductase.
openaire   +3 more sources

Structural analysis of thioredoxins.

, 2015
(A) Structural comparison of AfTrx3HP (green) with thioredoxins from S. aureus (magenta), E. coli (orange), T. thermophilus (grey), and A. acidocaldarius (sky blue) with r.m.s.d’s of 0.66 Å, 0.68 Å, 0.40 Å, and 0.70 Å respectively.
Sean J. Elliott (721232), Kathryn D. Bewley (721226), Sangha Mitra (721229), Catherine L. Drennan (721231), Mishtu Dey (721227), Rebekah E. Bjork (721228), Sarah E. Chobot (721230)   +6 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source