Results 51 to 60 of about 8,012 (300)
Advanced Science, EarlyView.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
The paternal genome and the health of the assisted reproductive technology child
Asian Journal of Andrology, 2015 As a number of children born by assisted reproductive technology (ART) are increasing each year across the developed world, the health of such offspring is a matter of public concern.
Sheena EM Lewis, Kishlay Kumar
doaj +1 more source
Comparison of Reduction Activity of three Rice (Oryza sativa) Thioredoxin Isoforms in Reaction with Insulin [PDF]
مجله بیوتکنولوژی کشاورزی, 2012 Thioredoxins (Trxs) are ubiquitous, low-molecular-mass proteins with two cysteins in their active site WC(G/P)PC which are involved in reversible reduction of disulfide bonds. Plants contain several forms of Trxs.
zahra popzan, Azar SHahpiri
doaj +1 more source
PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Frontiers in Veterinary Science, 2021 Toxoplasmosis caused by infection with Toxoplasma gondii is an important parasitic zoonosis with a worldwide distribution. In this study, we examined the functions of two thioredoxins (namely CTrp26 and CTrx1) of T. gondii tachyzoites by generation of HA
Zhi-Wei Zhang +8 more
doaj +1 more source
Thiol Reductases in Deinococcus Bacteria and Roles in Stress Tolerance
Antioxidants, 2022 Deinococcus species possess remarkable tolerance to extreme environmental conditions that generate oxidative damage to macromolecules. Among enzymes fulfilling key functions in metabolism regulation and stress responses, thiol reductases (TRs) harbour ...
Arjan de Groot +3 more
doaj +1 more source
Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae
, 2010 Background. Protein-SH groups are amongst the most easily oxidized residues in proteins, but irreversible oxidation can be prevented by protein glutathionylation, in which protein-SH groups form mixed disulphides with glutathione.
Dawes, IW ; https://orcid.org/ +18 more
core +1 more source
Journal of VirologyDisulfide exchange is underexplored as a mechanism influencing HIV-1 entry. Prior studies demonstrated that redox enzyme inhibition can prevent HIV-1 infection but with limited mechanistic explanation.
Charles G. Ang +7 more
doaj +1 more source
Redox regulation of mammalian sperm capacitation
Asian Journal of Andrology, 2015 Capacitation is a series of morphological and metabolic changes necessary for the spermatozoon to achieve fertilizing ability. One of the earlier happenings during mammalian sperm capacitation is the production of reactive oxygen species (ROS) that will ...
Cristian O′Flaherty
doaj +1 more source
Animal and plant mitochondria contain specific thioredoxins
, 1989 Thioredoxins have been purified from pig heart and potato tuber mitochondria which differ in Chromatographie behaviour, enzyme activating capacity, and slightly higher molecular mass (Mr = 12500) from the major thioredoxin(s) present in mitochondria-free
Angela Buch +5 more
core +1 more source