Results 91 to 100 of about 2,776 (198)

Conformational Studies on Some Inhibitors of Thermolysin and EC 3.4.24.11 [PDF]

, 1987
Molecular modeling is an exciting new approach in the field of drug design. A molecule's activity as a drug is dependent upon its conformation i.e. the three dimensional arrangement of its functional groups.
Forrest, Fiona Ruth Ferguson
core  

Prodrugs targeting the central nervous system (cns) [PDF]

, 2015
The classical approach for delivery of drugs into the central nervous system (CNS) is associated with adverse effects and it has many limitations. Therefore, extensive efforts have been done in searching and developing novel methods for achieving such
Karaman, Donia, Karaman, Rafik, Salameh, Falasteen   +2 more
core  

Mechanisms involved in the pathogenesis of airway hyperresponsiveness in allergic asthma [PDF]

, 2015
星薬科大学1994年
千葉 義彦
core   +1 more source

Effects of neutral endopeptidase (neprilysin) inhibition on the response to other vasoactive peptides in small human resistance arteries: studies with thiorphan and omapatrilat.

Cardiovascular Therapeutics, 2014
J. Dalzell, A. Seed, C. Berry, C. Whelan, M. Petrie, N. Padmanabhan, Amanda L. Clarke, Fiona Biggerstaff, C. Hillier, J. McMurray   +9 more
semanticscholar   +1 more source

Prediction of Phytochemicals for Their Potential to Inhibit New Delhi Metallo β-Lactamase (NDM-1). [PDF]

Pharmaceuticals (Basel), 2023
Bibi Z, Asghar I, Ashraf NM, Zeb I, Rashid U, Hamid A, Ali MK, Hatamleh AA, Al-Dosary MA, Ahmad R, Ali M.   +10 more
europepmc   +1 more source

Distinct Inhibition Modes of New Delhi Metallo-β-lactamase-1 Revealed by NMR Spectroscopy. [PDF]

JACS Au, 2023
Cheng K, Wu Q, Yao C, Chai Z, Jiang L, Liu M, Li C.   +6 more
europepmc   +1 more source

Expression of neutral endopeptidase activity during clinical and experimental acute lung injury [PDF]

Fumimasa Amaya, Kazutoshi Kiuchi, Kentaro Oh-hashi, Satoru Hashimoto, Soshi Hashimoto   +4 more
core   +1 more source

New Borane-Protected Derivatives of α-Aminophosphonous Acid as Anti-Osteosarcoma Agents: ADME Analysis and Molecular Modeling, In Vitro Studies on Anti-Cancer Activities, and NEP Inhibition as a Possible Mechanism of Anti-Proliferative Activity. [PDF]

Int J Mol Sci, 2022
Mizerska-Kowalska M, Sowa S, Donarska B, Płaziński W, Sławińska-Brych A, Tomasik A, Ziarkowska A, Łączkowski KZ, Zdzisińska B.   +8 more
europepmc   +1 more source

Spectroscopic and biochemical characterization of metallo-β-lactamase IMP-1 with dicarboxylic, sulfonyl, and thiol inhibitors. [PDF]

Bioorg Med Chem, 2021
Zhang H, Yang K, Cheng Z, Thomas C, Steinbrunner A, Pryor C, Vulcan M, Kemp C, Orea D, Paththamperuma C, Chen AY, Cohen SM, Page RC, Tierney DL, Crowder MW.   +14 more
europepmc   +1 more source

Tripchlorolide attenuates β-amyloid generation by inducing NEP activity in N2a/APP695 cells. [PDF]

Transl Neurosci, 2021
Zeng Y, Li Y, Shen H, Lin N, Zhang J.
europepmc   +1 more source