Results 141 to 150 of about 2,711 (217)

Tolerance in Thalamic Paraventricular Nucleus Neurons Following Chronic Treatment of Animals with Morphine. [PDF]

eNeuro
Koita O, Lebowitz JJ, Williams JT.
europepmc   +1 more source

Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice.

Endocrinology
Esser N, Mongovin SM, Barrow BM, Zraika S.   +3 more
europepmc   +1 more source

Asymmetric synthesis of the enkephalinase inhibitor thiorphan

The Journal of Organic Chemistry, 1985
Synthese de la N-[mercaptomethyl-2 phenyl-3 propionyl] glycine(thiorphane) a partir d'oxazolidones-2 ...
David A. Evans, David J. Mathre, William L. Scott   +2 more
semanticscholar   +4 more sources

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Polarization Controlled Assembly of Ultrathin Thiorphan Nanostructures on ZnO Surface Facets.

Langmuir, 2023
Despite the importance of thiorphan as a small molecule with vital biological roles, its interactions with zinc oxide (ZnO) nanomaterials that are prospective in drug delivery and theranostic applications have not yet been sufficiently explored. Here the
E. Ukraintsev, H. Hematian, B. Rezek
semanticscholar   +3 more sources

Thiorphan, an Inhibitor of Endopeptidase 24.11, Potentiates the Natriuretic Activity of Atrial Natriuretic Peptide

Journal of Cardiovascular Pharmacology, 1989
To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
Angelo J. Trapani, Glenn J. Smits, Dean E. McGraw, Kerry L. Spear, J P Koepke, Gillian M. Olins, Edward H. Blaine   +6 more
semanticscholar   +5 more sources

Thiorphan and retro-thiorphan display equivalent interactions when bound to crystalline thermolysin.

Biochemistry, 1989
The three-dimensional structures of (S)-thiorphan and (R)-retro-thiorphan bound to thermolysin have been determined crystallographically and refined to residuals of 0.183 and 0.187 at 1.7-A resolution. Thiorphan [N-[(S)-2-(mercaptomethyl)-1-oxo-3-phenylpropyl]glycine] [HSCH2CH(CH2C6H5)CONHC-H2COOH] and retro-thiorphan [[[(R)-1-(mercaptomethyl)-2 ...
S. Roderick, M. Fournie-Zaluski, B. Roques, B. Matthews   +3 more
semanticscholar   +4 more sources

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

Nature, 1980
There is both theoretical and therapeutic interest in establishing whether the signals conveyed by the enkephalins are turned off under the action of a specific peptidase which might, in this case, represent a target for a new class of psychoactive agents.
B. Roques, M. Fournie-Zaluski, E. Soroca, J. Lecomte, Bernard Malfroy, C. Llorens, Jean-Charles Schwartz   +6 more
semanticscholar   +3 more sources

A comparative study between angiotensin receptor neprilysin inhibitor (thiorphan/irbesartan) with each of nitrate and carvedilol in a rat model of myocardial ischemic reperfusion injury

Fundamental & Clinical Pharmacology, 2023
The combined angiotensin receptor neprilysin inhibitor is a promising cardioprotective pharmacological agent. This study investigated the beneficial effects of thiorphan (TH)/irbesartan (IRB), in myocardial ischemia–reperfusion (IR) injury, compared to ...
Takwa Mohammed Abdulsalam, A. Hasanin, R. H. Mohamed, Eman Y Khairy, Dalia Mahmoud, Eman K. Habib, A. Badawy   +6 more
semanticscholar   +1 more source

Angiotensin receptor–neprilysin inhibitor (thiorphan/irbesartan) improved cardiac function in a rat model of myocardial ischemic reperfusion injury

Fundamental & Clinical Pharmacology, 2022
Mitochondria‐mediated apoptosis plays a critical role in myocardial ischemia reperfusion (IR) injury and causes a negative impact on cardiac efficiency and function.
Takwa Mohammed Abdulsalam, A. Hasanin, R. H. Mohamed, Eman Y Khairy, Dalia Mahmoud, Eman K. Habib, A. Badawy   +6 more
semanticscholar   +1 more source

Enantiomers of [R,S]-thiorphan: Dissociation of analgesia from enkephalinase a inhibition

Life Sciences, 1985
The [R] and [S] enantiomers of the enkephalinase A inhibitor [R,S]-thiorphan have been prepared by asymmetric synthesis. The [S] isomer is principally responsible for the angiotensin converting enzyme inhibitory activity of [R,S]-thiorphan, whereas there were only small differences in the ability of the [R] and [S] isomers to inhibit enkephalinase both
William L. Scott, Laurane G. Mendelsohn, Marlene L. Cohen, David A. Evans, Robert C.A. Frederickson   +4 more
openalex   +4 more sources