Results 141 to 150 of about 2,776 (198)
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Potentiation of [D-Ala2]enkephalinamide analgesia in rats by thiorphan
European Journal of Pharmacology, 1982The effect of thiorphan, an inhibitor of enkephalin dipeptidyl carboxypeptidase, was tested in the rat tail-flick test. When given alone up to 100 mg/kg s.c., thiorphan had no effect. However, thiorphan (30 mg/kg, s.c.) potentiated intraventricularly administered [D-Ala2,Met5]enkephalinamide (DEAEM) and its [Leu5]-derivative, whereas it had no effect ...
R E, Chipkin +3 more
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Effects of thiorphan on the antinociceptive actions of intrathecal [D-Ala2,Met5]enkephalin
European Journal of Pharmacology, 1982The intrathecal administration of thiorphan (dl-3-mercapto-2-benzylpropranoyl-glycine) had no effect in doses up to 70 microgram on the rat hot plate and tail flick. Administrations of these doses of thiorphan concurrently or up to 1 h prior to the intrathecal administration of [D-Ala2, Met5] enkephalin resulted in a dose dependent, leftward shift in ...
T L, Yaksh, G J, Harty
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Potentiation of stress-induced analgesia (SIA) by thiorphan and its block by naloxone
Life Sciences, 1982Exposure of rats to inescapable footshock produces an analgesic effect. To determine if endogenously released enkephalins play a role in this phenomenom, rats were treated with the enkephalinase inhibitor thiorphan (T), exposed to inescapable stress, and tested in the tail-flick test for antinociception.
R E, Chipkin, M B, Latranyi, L C, Iorio
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Effect of thiorphan on response of the guinea-pig gallbladder to tachykinins
European Journal of Pharmacology, 1989Tachykinins produced a concentration-related contraction of the isolated guinea-pig gallbladder, with a rank order of potency neurokinin A (NKA) greater than Arg-neurokinin B = neurokinin B (NKB) greater than substance P (SP). Only the effect of SP was potentiated by thiorphan (0.1-10 microM).
C. A. Maggi +8 more
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Journal of Cardiovascular Pharmacology, 1989
To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
A J, Trapani +6 more
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To evaluate the role of endopeptidase 24.11 in metabolism of atrial natriuretic peptide (ANP) in vivo, we examined the effect of thiorphan, an inhibitor of this enzyme, on plasma ANP concentrations and the cardiovascular and renal actions of ANP(99-126).
A J, Trapani +6 more
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Neuroscience Letters, 2003
Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD. Decreased degradation of Abeta is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme responsible for Abeta degradation.
Amanda J, Newell +6 more
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Studies on the pathogenesis of Alzheimer's disease (AD) suggest overproduction of amyloid beta (Abeta) may not be the only pathogenic route to AD. Decreased degradation of Abeta is another possible disease mechanism. Neprilysin is a neutral endopeptidase that has been proposed to be the major enzyme responsible for Abeta degradation.
Amanda J, Newell +6 more
openaire +3 more sources
Fundamental & Clinical Pharmacology, 2023
The combined angiotensin receptor neprilysin inhibitor is a promising cardioprotective pharmacological agent. This study investigated the beneficial effects of thiorphan (TH)/irbesartan (IRB), in myocardial ischemia–reperfusion (IR) injury, compared to ...
Takwa Mohammed Abdulsalam +6 more
semanticscholar +1 more source
The combined angiotensin receptor neprilysin inhibitor is a promising cardioprotective pharmacological agent. This study investigated the beneficial effects of thiorphan (TH)/irbesartan (IRB), in myocardial ischemia–reperfusion (IR) injury, compared to ...
Takwa Mohammed Abdulsalam +6 more
semanticscholar +1 more source
Fundamental & Clinical Pharmacology, 2022
Mitochondria‐mediated apoptosis plays a critical role in myocardial ischemia reperfusion (IR) injury and causes a negative impact on cardiac efficiency and function.
Takwa Mohammed Abdulsalam +6 more
semanticscholar +1 more source
Mitochondria‐mediated apoptosis plays a critical role in myocardial ischemia reperfusion (IR) injury and causes a negative impact on cardiac efficiency and function.
Takwa Mohammed Abdulsalam +6 more
semanticscholar +1 more source
European Journal of Pharmacology, 2020
Ventricular arrhythmias are considered as a major risk of sudden cardiac death. This study was designed to investigate the potential effects of angiotensin receptor neprilysin inhibitor; thiorphan/irbesartan (TH/IRB) combination therapy on myocardial ...
Takwa Mohammed Abdulsalam +3 more
semanticscholar +1 more source
Ventricular arrhythmias are considered as a major risk of sudden cardiac death. This study was designed to investigate the potential effects of angiotensin receptor neprilysin inhibitor; thiorphan/irbesartan (TH/IRB) combination therapy on myocardial ...
Takwa Mohammed Abdulsalam +3 more
semanticscholar +1 more source
Study of thiorphan degradation
International Journal of Pharmaceutics, 1988Abstract The degradation of the enkephalinase inhibitor thiorphan was studied. Liquid chromatography UV and electrochemical detections and several techniques of spectrometry showed that the degradation was oxidative and generates diastereoisomers of the corresponding disulfide.
F. Gimenez +6 more
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