ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function [PDF]
, 2010 Activating the amyloid cascade by inhibiting the Aβ-degrading enzyme neprilysin in targeted replacement mice, which express either apoE4 or apoE3, results in the specific accumulation of oligomerized Aβ42 in hippocampal CA1 neurons of the apoE4 mice.
Belinson, Haim +6 more
core +4 more sources
Neprilysin inhibitors and risk of Alzheimer's disease: A future perspective
Journal of Cellular and Molecular Medicine, Volume 28, Issue 2, January 2024.Abstract Alzheimer's disease (AD) is a heterogeneous neurodegenerative disease with multifaceted neuropathological disorders. AD is characterized by intracellular accumulation of phosphorylated tau proteins and extracellular deposition of amyloid beta (Aβ).
Naif H. Ali +8 more
wiley +1 more source
Role of endogenous endothelin-1 in the pathogenesis of gastric mucosal injury induced by local ischemia and reperfusion in rats [PDF]
, 1998 Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no.
Hassan Mahmudul
core
Brain Neprilysin Activity and Susceptibility to Transgene-Induced Alzheimer Amyloids [PDF]
, 2005 Neprilysin (NEP) is a zinc metalloproteinase that degrades enkephalins, endothelins, and the Alzheimer’s disease amyloid ß (Aß) peptides. NEP-deficient mice possess increased levels of brain Aß1-40 and Aß1-42. The objective of this study was to determine
Carter, Troy L. +4 more
core +1 more source
Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis [PDF]
, 2018 Alzheimer's disease, responsible for the vast majority of dementia cases in the elderly population, is caused by accumulation of toxic levels of amyloid β peptide (Aβ) in the brain.
Mohajeri, M., Wolfer, David
core
The Analgesic Activity of Bestatin as a Potent APN Inhibitor [PDF]
, 2010 Bestatin, a small molecular weight dipeptide, is a potent inhibitor of various aminopeptidases as well as LTA4 hydrolase. Various physiological functions of Bestatin have been identified, viz.: (1) an immunomodifier for enhancing the proliferation of ...
Jia, Mei-Rong, Wei, Tao, Xu, Wen-Fang
core +3 more sources
Natural Products in Organic Synthesis [PDF]
, 1996 A resume of four lectures presented by the author during a one month visit to BIOTROP in 1995. The seminars were held at the University of Indonesia at Depok, the Technical Institute in Bandung, the Bogor Agricultural Institute and at ...
BURNELL, R. H. (ROBERT)
core +1 more source
Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation [PDF]
, 2000 BACKGROUND: The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization process in response to agonist stimulation.
Gastard, Myriam
core +3 more sources
Neprilysin is a mediator of alternative renin-angiotensin-system activation in the murine and human kidney [PDF]
, 2016 Cardiovascular and renal pathologies are frequently associated with an activated renin-angiotensin-system (RAS) and increased levels of its main effector and vasoconstrictor hormone angiotensin II (Ang II). Angiotensin-converting-enzyme-2 (ACE2) has been
Antlanger, M. +16 more
core +2 more sources
Neprilysin deficiency reduces hepatic gluconeogenesis in high fat-fed mice. [PDF]
Peptides, 2023 Esser N +4 more
europepmc +1 more source