Results 221 to 230 of about 47,813 (302)

Age‐Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function

Aging Cell, Volume 25, Issue 6, June 2026.
Sciatic nerve proteome remodeling, particularly of mitochondrial‐centric pathways, occurs at 4 months of age in 5xFAD mice, coinciding with onset of neuromuscular dysfunction. Exercise or the acetylcholinesterase inhibitor donepezil, begun prior to onset, delays these phenotypes, suggesting early peripheral phenotypes of Alzheimer's Disease may have ...
Matthew H. Brisendine, Dijanira Q. Nieves‐Esparcia, Orion S. Willoughby, Brieann Brown, John R. Brown, Daniel S. Braxton, Shelby N. Henry, Colin S. McCoin, John P. Thyfault, Jill K. Morris, Steven Poelzing, Robert W. Grange, Timothy J. Jarome, Charles P. Najt, Joshua C. Drake   +14 more
wiley   +1 more source

Asymmetric Organocatalytic Addition of Malononitrile to Trifluoromethyl Arylketimines: A Viable Entry to Chiral α-CF₃ Quaternary Aminoesters. [PDF]

Molecules
Ivkovic M, Franco F, Rossi S, Ferrario S, Puglisi A, Benaglia M.   +5 more
europepmc   +1 more source

Autoclaved Peanuts Exhibit Reduced Immunoglobulin E Binding and Improved Oral Tolerability

Allergy, Volume 81, Issue 6, Page 2133-2144, June 2026.
This study evaluates the effects of heat and pressure autoclaving on peanut proteins, IgE binding, and oral tolerability. Heat and pressure autoclaving breaks down peanut proteins and allergens, contributing to reduced peanut‐specific IgE binding. Autoclaved peanuts are associated with decreased skin test reactivity and greater oral tolerability in ...
Casey G. Cohen, Diana Toscano‐Rivero, Eisha A. Ahmed, Adnan Al Ali, Wei Zhao, Danbing Ke, Duncan Lejtenyi, Liane Beaudette, Hana Chazbey, Abdulaziz S. Alrafiaah, Carmen H. Li, Kurt Dejgaard, Albert M. Berghuis, Bertrand J. Jean‐Claude, Christine McCusker, Thomas Eiwegger, Moshe Ben‐Shoshan, Bruce D. Mazer   +17 more
wiley   +1 more source

Structure-guided optimization of N-sulfonylpiperidines toward potent multi-target anticancer agents. [PDF]

Sci Rep
Al Jazairi AGS, Elgammal WE, Mohamed MBI, Seleem MA, Bashandy MS.   +4 more
europepmc   +1 more source

Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim Myocardial infarction (MI) is one of the leading causes of death worldwide. MI is associated with cardiac structural and functional alterations. Among these, cardiac fibrosis may be significantly influenced by mitochondrial dysfunction. We sought to evaluate whether the injection of functional mitochondria from healthy muscle could improve
María Cuesta‐Corral, Alejandro Montoro‐Garrido, Ana Romero‐Miranda, Fabián Islas, Bunty Ramchandani, Ricardo Gredilla, Joaquín Fernández‐Irigoyen, Enrique Santamaría, Beatriz Delgado‐Valero, Sara Jiménez‐González, Raquel Rodrigues Díez, María Luisa Nieto, Victoria Cachofeiro, Ernesto Martínez‐Martínez   +13 more
wiley   +1 more source

Photocatalytic generation of amidine carbon radicals for aminodihydroquinoline synthesis. [PDF]

Nat Commun
Yao X, Yu J, Lin G, Mei H, Zhang K, Cai L.   +5 more
europepmc   +1 more source

Design, Synthesis of Novel Quinazolinone Derivatives and Evaluation of EGFR Kinase Inhibition Activity via In Vitro and In Silico Studies

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Seventeen new quinazolinone derivatives were synthesized in pure form. Compound 4j showed the highest inhibitory activity against the A549 cell line and induced apoptosis via caspase‐3 activation in MCF‐7 cells. 4j inhibited EGFR enzyme twice as effectively as gefitinib.
Aybüke Züleyha Kaya, Asaf Evrim Evren, Gülşen Akalın‐Çiftçi, Leyla Yurttaş   +3 more
wiley   +1 more source

A Multiphase Composite for High-Performance Alkaline Zinc Batteries. [PDF]

Molecules
Sun Z, Wang J, Guan J, Mei Y, Song W, Wang H, Luo W, Cai X.   +7 more
europepmc   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Ion-Pair Breakers and Anionic Brønsted Acids for Helmholtz-Layer Catalysis with External Electric Fields in Microfluidic Capacitors. [PDF]

JACS Au
Paraja M, Matile S.
europepmc   +1 more source