Results 31 to 40 of about 5,312,533 (301)

Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway

Cancer Medicine, 2020
Radioresistance was the main reason for local recurrence and metastasis of nasopharyngeal carcinoma. Tetrandrine is reported as an antitumor drug via inducing cell cycle arrest and apoptosis.
Jun Wang, Zhouzhou Yao, Xiaoping Lai, Hongwei Bao, Yue Li, Shuaixiang Li, Lihong Chang, Gehua Zhang   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Tumor-infiltrating CD4+ CD25+ FOXP3+ Treg is associated with plasma EBV DNA and disease progression in nasopharyngeal carcinoma

Infectious Agents and Cancer
Background Regulatory T cells (Tregs) play a significant role in immune evasion within the tumor microenvironment (TME). Nasopharyngeal carcinoma (NPC) is strongly associated with Epstein-Barr virus (EBV) infection.
Enzi Feng, Yaoyu Yang, Jie Yang, Rongyi Hu, Ling Tian, Xinyu Yang, Meng Yang, Qianqian Qu, Yanxin Ren, Xiaojiang Li   +9 more
doaj   +1 more source

Incidence of third head of biceps brachii muscles

Journal of Institute of Medicine Nepal, 1999
This study shows the incidence of extra head of Biceps Brachii which was found during routine dissection by the first year students of MBBS at Sri Devraj Urs Medical College, Tamaka, Kolar, Karnataka (State), India.
Arun Kumar S.Bilodi, M.B. Sanikop, Jeevan Prakash   +2 more
openaire   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Topical Therapies for Management of Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Steroid-Eluting Stents

Ear, Nose & Throat Journal
Objectives: Steroid-eluting stent implantation after endoscopic sinus surgery (ESS) effectively alleviates postoperative symptoms and polyp recurrence in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
Zhidi Zhang MD, Qiang Zuo MD, Yali Du MD, Hailing Jiang BM, Jiayue Wang MD, Furong Ma MD, Yinghong Zhang MD   +6 more
doaj   +1 more source

Avascular Necrosis of the Head of the Third Metacarpal Bone

Journal of the Korean Orthopaedic Association, 2012
Avascular necrosis of the metacarpal head named as ‘Dieterich disease’ is a very rare condition. Because of the lack of information about the natural course and treatment of this disease, the ideal treatment has not been established as yet. We report a case of avascular necrosis that occurred at the 3rd metacarpal head after fractures of the 4th and ...
Youn-Moo Heo, Sang-Bum Kim, Jin-Woong Yi, Kwang-Kyoon Kim, Jung-Bum Lee, Seung-Kwan Ryu   +5 more
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Correlation between hearing loss and mild cognitive impairment in the elderly population: Mendelian randomization and cross-sectional study

Frontiers in Aging Neuroscience
BackgroundHearing loss and tinnitus have been linked to mild cognitive impairment (MCI); however, the evidence is constrained by ethical and temporal constraints, and few prospective studies have definitively established causation.
Tong Xu, Tao Zong, Jing Liu, Le Zhang, Hai Ge, Rong Yang, Zongtao Liu   +6 more
doaj   +1 more source