Results 91 to 100 of about 2,306,059 (316)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Third order distortion and spectacle lens design
, 1985 Third order (primary) aberration theory has had little application to the design of aspheric spectacle lenses. Such an application would be useful because: \ud 1.
Atchison, David A.
core
MathematicsThis paper focuses on the oscillatory properties of the third-order semi-canonical nonlinear delay differential equation. By using the new canonical transform method, we transformed the studied equation into a canonical-type equation, which simplified ...
Ekambaram Chandrasekaran +3 more
doaj +1 more source
Quasi-adjoint third order difference equations: oscillatory and asymptotic behavior
International Journal of Mathematics and Mathematical Sciences, 1986 In this paper, asymptotic properties of solutions ofΔ3Vn+Pn−1Vn+1=0 (E+)are investigated via the quasi-adjoint equationΔ3Un+PnUn+2=0. (E−)A necessary and sufficient condition for the existence of oscillatory solutions of (E+) is ...
B. Smith
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Boundedness and square integrability of solutions of certain third-order differential equations [PDF]
, 2018 summary:We establish some new sufficient conditions which guarantee the boundedness and square integrability of solutions of certain third order differential equation. Example is included to illustrate the results.
Moussadek Remili +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Analýza sociálnej štruktúry stredovekej spoločnosti
Historická sociologie, 2014 This study concentrates on the analysis of social structure of medieval society and accordingly on the acquisition of knowledge (1) about their orderliness, (2) inner processes (3) and least partially their influence on the process of formation of West ...
Margita Minichová
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Third-order nonlinearity OPO: Schmidt Mode Decomposition And Tripartite Entanglement
, 2017 We investigate quantum properties of light in optical parametric oscillators (OPOs) based on four-wave mixing gain in media with third-order non-linearities.
P. Nussenzveig (17501376) +2 more
core +1 more source