Results 71 to 80 of about 8,993,640 (291)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Uniformly boundedness of a class of non-linear differential equations of third order with multiple deviating arguments

Cubo, 2012
This paper deals with a certain third-order non-linear differential equation with multiple deviating arguments. Some sufficient conditions are set up for all solutions and their derivatives to be uniformly bounded.En este artículo se estudia un tipo de ...
Cemil Tunc, Hilmi Ergören
doaj  

Quasi-adjoint third order difference equations: oscillatory and asymptotic behavior

International Journal of Mathematics and Mathematical Sciences, 1986
In this paper, asymptotic properties of solutions ofΔ3Vn+Pn−1Vn+1=0          (E+)are investigated via the quasi-adjoint equationΔ3Un+PnUn+2=0.             (E−)A necessary and sufficient condition for the existence of oscillatory solutions of (E+) is ...
B. Smith
doaj   +1 more source

Third-order integrable difference equations generated by a pair of second-order equations

, 2005
We show that the third-order difference equations proposed by Hirota, Kimura and Yahagi are generated by a pair of second-order difference equations. In some cases, the pair of the second-order equations are equivalent to the Quispel-Robert-Thomson(QRT)
Daisuke Takahashi, Hirota R, Junta Matsukidaira, Kajiwara K, Ramani A, Takenawa T, Tsuda T   +6 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Third order matching is decidable

Annals of Pure and Applied Logic, 1994
The higher order matching problem is the problem of determining whether a term is an instance of another in the simply typed $λ$-calculus, i.e. to solve the equation a = b where a and b are simply typed $λ$-terms and b is ground. The decidability of this problem is still open.
openaire   +3 more sources

The Longitudinal Structure Function at the Third Order

, 2004
We compute the complete third-order contributions to the coefficient functions for the longitudinal structure function F_L, thus completing the next-to-next-to-leading order (NNLO) description of unpolarized electromagnetic deep-inelastic scattering in ...
A. Vogt, Adloff, Adloff, Akhoury, Akhoury, Alekhin, Bauerdick, Blümlein, Catani, Chekanov, Eidelman, Gehrmann, Guillen, J.A.M. Vermaseren, Kazakov, Kazakov, Klein, Kotikov, Larin, Larin, Lobodzinska, Martin, Moch, Moch, Moch, Moch, Pumplin, Remiddi, Retey, S. Moch, van Neerven, van Neerven, van Neerven, van Neerven, Vogt, Vogt, Vogt, Vollinga, Zijlstra, Zijlstra, Zijlstra   +40 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Towards an understanding of third-order galaxy-galaxy lensing

, 2012
Third-order galaxy-galaxy lensing (G3L) is a next generation galaxy-galaxy lensing technique that either measures the excess shear about lens pairs or the excess shear-shear correlations about lenses.
Bartelmann, Bartelmann, Bower, Brainerd, Cooray, D. Kübler, De Lucia, Fischer, Griffiths, Guzik, Hoekstra, Hoekstra, Johnston, Kaiser, Kleinheinrich, Mandelbaum, Mandelbaum, Mandelbaum, P. Schneider, P. Simon, Parker, Pen, Scherrer, Schneider, Schrabback, Seljak, Sheldon, Simon, Simon, Tyson, van Uitert, Weinberg   +31 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source