Molecular, serological and in vitro culture-based characterization of Bourbon virus, a newly described human pathogen of the genus Thogotovirus [PDF]
Journal of Clinical Virology, 2015 In June of 2014, a previously healthy man from Kansas with a recent history of tick exposure died from complications related to an illness marked by fever, thrombocytopenia and leukopenia. An isolate was derived from the blood of this patient during the course of diagnostic testing.
Amy J. Lambert +7 more
openaire +2 more sources
Mx1 in hematopoietic cells protects against Thogoto virus infection [PDF]
, 2019 Myxovirus resistance 1 (Mx1) is an interferon-induced gene that encodes a GTPase that plays an important role in the defense of mammalian cells against influenza A and other viruses.
Kochs, Georg +4 more
core +2 more sources
Synthesis of IFN-β by Virus-Infected Chicken Embryo Cells Demonstrated with Specific Antisera and a New Bioassay [PDF]
, 2004 Transcripts of interferon-α(IFN-α) and IFN-β genes are present in virus-infected chicken cells, but because of a lack of appropriate assays and reagents, it was unclear if biologically active IFN-β is secreted.
Harlin, Olof +4 more
core +1 more source
Surveillance for Tick-Borne Viruses Near the Location of a Fatal Human Case of Bourbon Virus (Family Orthomyxoviridae: Genus Thogotovirus) in Eastern Kansas, 2015 [PDF]
Journal of Medical Entomology, 2018 Bourbon virus (Family Orthomyxoviridae: Genus Thogotovirus) was first isolated from a human case-patient residing in Bourbon County, Kansas, who subsequently died. Before becoming ill in late spring of 2014, the patient reported several tick bites. In response, we initiated tick surveillance in Bourbon County and adjacent southern Linn County during ...
Harry M, Savage +9 more
openaire +2 more sources
Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains. [PDF]
PLoS ONE, 2014 Orthomyxovirus Influenza A virus (IAV) heterotrimeric polymerase performs transcription of viral mRNAs by cap-snatching, which involves generation of capped primers by host pre-mRNA binding via the PB2 subunit cap-binding site and cleavage 10-13 ...
Delphine Guilligay +7 more
doaj +1 more source
Proteomics computational analyses suggest that the bornavirus glycoprotein is a class III viral fusion protein (γ penetrene) [PDF]
, 2009 Background Borna disease virus (BDV) is the type member of the Bornaviridae, a family of viruses that induce often fatal neurological diseases in horses, sheep and other animals, and have been proposed to have roles in certain psychiatric diseases of ...
Courtney E Garry, Robert F Garry
core +3 more sources
Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction. [PDF]
Sci AdvAntiviral restriction factors such as MxA (myxovirus resistance protein A) inhibit many viruses. Viral escape drives restriction factors to evolve rapidly at virus-binding interfaces to regain defense.
Geiger RA +6 more
europepmc +3 more sources
Detection of Brucella abortus DNA and RNA in different stages of development of the sucking louse Haematopinus tuberculatus [PDF]
, 2013 Background: Brucellosis is considered the world’s most widespread zoonotic infection. It causes abortion and sterility in livestock leading to serious economic losses and has even more serious medical impact in humans, since it can be a trigger to more
Borriello G +8 more
core +1 more source
Humoral immune response after seasonal influenza vaccination [PDF]
, 2023 Introduction: Seasonal vaccination provides short-lasting and strain specific protection. Different factors influence efficacy and effectiveness and are related to the vaccine and the receptor.
Sánchez de Prada, Laura
core +1 more source
Advances in Virology, Volume 2018, Issue 1, 2018., 2018 Advances in the next generation sequencing (NGS) technologies have significantly increased our ability to detect new viral pathogens and systematically determine the spectrum of viruses prevalent in various biological samples. In addition, this approach has also helped in establishing the associations of viromes with many diseases.
Andrey A. Ayginin +10 more
wiley +1 more source