Results 71 to 80 of about 1,390,349 (298)

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Three-dimensional quantitative structure–activity relationship and docking studies in a series of anthocyanin derivatives as cytochrome P450 3A4 inhibitors

Advances and Applications in Bioinformatics and Chemistry, 2014
Sergey Shityakov,1 István Puskás,2 Norbert Roewer,1 Carola Förster,1 Jens Broscheit11Department of Anesthesia and Critical Care, University of Würzburg, Würzburg, Germany; 2CycloLab Cyclodextrin Research and Development ...
Shityakov S, Puskás I, Roewer N, Förster C, Broscheit J   +4 more
doaj  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

A scoping review on the potential of three-dimensional bioprinting in auricular cartilage regeneration

SRM Journal of Research in Dental Sciences
Background The human ear significantly influences facial appearance. Auricular abnormalities can arise from many causes, and the cartilage cannot self-regenerate.
Eman Assem Ibrahim, Moamen Mohsen Sarhan, Salah Ezzelarab, Mona K. Marei   +3 more
doaj   +1 more source

Surface Scanning-Based Texture Atlas for Voxelized 3D Object

IEEE Access, 2020
The representation of voxel colors has become crucial because voxelized 3D data are used in a variety of applications. In particular, texture atlases are widely used for representing voxel colors.
Tae Young Jang, Seong Dae Kim, Sung Soo Hwang   +2 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Application of Three-Dimensional Technology for the Preoperative Evaluation of Retroperitoneal Tumors

IEEE Access, 2019
With the development of computer medical imaging technology, three-dimensional technology has been gradually applied in medicine. We try to investigate the application value of 3D technology in the preoperative evaluation of retroperitoneal tumors.
Zhaojie Su, Jiajia Chen, Zhiyuan Shi, Xiaogang Xia, Fuzhen Chen, Boliang Wang, Zhihai Peng, Wengang Li   +7 more
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Comparative Analysis of Object Digitization Techniques Applied to the Characterization of Deformed Materials in Ballistic Tests

Sensors, 2020
Several three-dimensional scanning methods have been developed and improved over the past 40 years. The peculiarities of each technique, associated with the computational advances of the period, allowed the increasing application and diffusion of the ...
Filipe Dmengeon Pedreiro Balbino, Khrissy Aracélly Reis Medeiros, Carlos Roberto Hall Barbosa   +2 more
doaj   +1 more source