Results 71 to 80 of about 1,518,426 (249)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Three dimensional visualization of histopathological data

TASK Quarterly
The histopathological examination provides information about the spatial assessment of pathological changes in the tissue. The authors present a method of extending this histopathological spatial assessment with a 3D view consisting of images of ...
Aleksandra Podwójcik
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

3D Sapiotyping: A Three Dimensional Definition

Journal of the Pakistan Medical Association
Precision medicine and personalized care have been at centre-stage in diabetology, and rightfully so. Various means of classification and clustering have been proposed to help identify clinical features, causative factors and ‘curative’ strategies for ...
Sanjay Kalra, Atul Dhingra, Nitin Kapoor
doaj   +1 more source

Effects of three-dimensionally printed polycaprolactone/β-tricalcium phosphate scaffold on osteogenic differentiation of adipose tissue- and bone marrow-derived stem cells [PDF]

, 2018
Hannara Park, Jin Soo Kim, Eun Jung Oh, Tae Jung Kim, Hyun Mi Kim, Jin Hyung Shim, Won Soo Yoon, Jung Bo Huh, Sung‐Hwan Moon, Seong Soo Kang, Ho Yun Chung   +10 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Modified continuity equation using left ventricular outflow tract three‐dimensional imaging for aortic valve area estimation [PDF]

, 2017
Pedro Pinto Teixeira, Rúben Ramos, Pedro Rio, Luísa Moura Branco, Guilherme Portugal, Ana Abreu, Ana Galrinho, Hugo Marques, Luísa Figueiredo, Filipa Ferreira   +9 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Can keratin scaffolds be used for creating three-dimensional cell cultures? [PDF]

, 2020
Marta Bochyńska-Czyż, Patrycja Redkiewicz, H. Kozłowska, Joanna Matalińska, Marek Konop, Piotr Kossoń   +5 more
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source