Results 141 to 150 of about 828,765 (377)

Tissue engineering in cardiovascular surgery: new approach to develop completely human autologous tissue [PDF]

, 2017
Objective: In cardiovascular tissue engineering, three-dimensional scaffolds serve as physical supports and templates for cell attachment and tissue development. Currently used scaffolds are still far from ideal, they are potentially immunogenic and they
Grunenfelder, Jurg, Hoerstrup, Simon P., Jockenhoevel, Stefan, Schoeberlein, Andreina, Turina, Marko, Ye, Qing, Zünd, Gregor   +6 more
core  

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Assessing Receptor Activation in 2D and 3D Cultured Hepatocytes: Responses to a Single Compound and a Complex Mixture

Toxics
Responding to global standards and legislative updates in Canada, including Bill S-5 (2023), toxicity testing is shifting towards more ethical, in vitro methods. Traditional two-dimensional (2D) monolayer cell cultures, limited in replicating the complex
Laiba Jamshed, Shanza Jamshed, Richard A. Frank, L. Mark Hewitt, Philippe J. Thomas, Alison C. Holloway   +5 more
doaj   +1 more source

Three-Dimensional Cell Culture Conditions Affect the Proteome of Cancer-Associated Fibroblasts.

Journal of Proteome Research, 2018
In vitro cell culture systems are an invaluable tool for cell biological research to study molecular pathways and to characterize processes critical in human pathophysiology.
R. Tölle, C. Gaggioli, J. Dengjel
semanticscholar   +1 more source

Actin, α-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells [PDF]

, 1975
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen in the fully spread out cells.
Lazarides, Elias
core   +1 more source

Three-Dimensional Culture of Glioblastoma Cells Using a Tissueoid Cell Culture System

ACTA HISTOCHEMICA ET CYTOCHEMICA
In classical cell culture techniques, cancer cells typically proliferate in a single layer by adhering to the undersurface of laboratory vessels. Consequently, concerns have been raised regarding the fidelity of the morphological and functional characteristics of these cultured cancer cells compared to those of their in vivo counterparts.
Okamoto, Natsume, Taniura, Naoko, Nakayama, Takahisa, Tanaka, Eri, Kageyama, Yusuke, Noujima, Mai, Kushima, Ryoji, Mukaisho, Ken-ichi   +7 more
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Media additives to promote spheroid circularity and compactness in hanging drop platform [PDF]

, 2015
Three-dimensional spheroid cultures have become increasingly popular as drug screening platforms, especially with the advent of different high throughput spheroid forming technologies.
Lesher-Perez, Sasha Cai, Leung, Brendan M., Matsuoka, Toshiki, Moraes, Christopher, Takayama, Shuichi   +4 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Establishment of an Three-Dimensional Vascularized Micro-Tumor Model and Screening of Chemotherapeutic Drugs

Technology in Cancer Research & Treatment
Breast cancer is the most common malignancy in women worldwide, and major challenges in its treatment include drug resistance and metastasis. Three-dimensional cell culture systems have received widespread attention in drug discovery studies but existing
Qian Ye MD, Juanru Wang BS, Boyang Wang BS, Min Zhao BS, Zhengsheng Wu PhD, Xiaoli Liu PhD   +5 more
doaj   +1 more source