Tuning the structure and properties of cell-embedded gelatin hydrogels for tumor organoids [PDF]
Polímeros, 2023 Tumor organoids have great potential as a 3D in vitro system to model cancer. In this work, we studied how the structure of hydrogels based on gelatin with methacryloyl groups (GeIMA) can affect their usage in tumor organoids.
Sarah Oliveira Lamas de Souza +5 more
doaj +1 more source
A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture [PDF]
, 2012 In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds are normally tested using static cell cultures but applied directly to tissue cultures in perfusion bioreactors.
Anderson +31 more
core +2 more sources
Cellular differentiation in three-dimensional lung cell cultures [PDF]
Cancer Biology & Therapy, 2008 Aspects of human biology that are not sufficiently addressed by current cell culture models are cellular differentiation and three-dimensional (3-D) structural organization. A model that more closely associates the presence and biology of organelles to molecular expressions relevant to these organelles may provide evidence of cellular differentiation ...
Roger A, Vertrees +6 more
openaire +2 more sources
Development of a novel 3D culture system for screening features of a complex implantable device for CNS repair [PDF]
, 2013 Tubular scaffolds which incorporate a variety of micro- and nanotopographies have a wide application potential in tissue engineering especially for the repair of spinal cord injury (SCI).
Bereiter-Hahn J. +31 more
core +3 more sources
Three-dimensional cell culture: A powerful tool in tumor research and drug discovery.
Oncology Letters, 2017 In previous years, three-dimensional (3D) cell culture technology has become a focus of research in tumor cell biology, using a variety of methods and materials to mimic the in vivo microenvironment of cultured tumor cells ex vivo.
Donglai Lv +4 more
semanticscholar +1 more source
Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns [PDF]
, 2017 Three-dimensional models of human intestinal epithelium mimic the differentiated form and function of parental tissues often not exhibited by two-dimensional monolayers and respond to Salmonella in key ways that reflect in vivo infections.
Barrila, Jennifer +17 more
core +1 more source
Three-Dimensional Cultures of Mouse Mammary Epithelial Cells [PDF]
, 2012 The mammary gland is an ideal "model organism" for studying tissue specificity and gene expression in mammals: it is one of the few organs that develop after birth and it undergoes multiple cycles of growth, differentiation and regression during the animal's lifetime in preparation for the important function of lactation.
Rana, Mroue, Mina J, Bissell
openaire +2 more sources
In Vitro Three-dimensional (3D) Cell Culture Tools for Spheroid and Organoid Models.
SLAS discovery : advancing life sciences R & D, 2023 Three-dimensional (3D) cell culture technology has been steadily studied since the 1990's due to its superior biocompatibility compared to the conventional two-dimensional (2D) cell culture technology, and has recently developed into an organoid culture ...
Sang‐Yun Lee +3 more
semanticscholar +2 more sources
Two-dimensional and three-dimensional cell culture models in vitro: pros and cons
Бюллетень сибирской медицины, 2018 Discovery and development of new chemical compounds with putative anti-cancer properties requires reliable predictive preclinical models for in vitro screening of efficacy.
E. S. Galimova, M. М. Galagudza
doaj +1 more source
Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]
, 2005 Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R. +4 more
core +1 more source