Results 41 to 50 of about 20,905,469 (291)
BioSig3D: High Content Screening of Three-Dimensional Cell Culture Models.
PLoS ONE, 2016 BioSig3D is a computational platform for high-content screening of three-dimensional (3D) cell culture models that are imaged in full 3D volume. It provides an end-to-end solution for designing high content screening assays, based on colony organization ...
Cemal Cagatay Bilgin +5 more
doaj +1 more source
The Role of Patient-Derived Organoids in Triple-Negative Breast Cancer Drug Screening
Biomedicines, 2023 Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes, with a grave prognosis and few effective treatment options.
Iason Psilopatis +3 more
doaj +1 more source
Three-Dimensional Cell Culture Matrices: State of the Art [PDF]
Tissue Engineering Part B: Reviews, 2008 Traditional methods of cell growth and manipulation on 2-dimensional (2D) surfaces have been shown to be insufficient for new challenges of cell biology and biochemistry, as well as in pharmaceutical assays. Advances in materials chemistry, materials fabrication and processing technologies, and developmental biology have led to the design of 3D cell ...
Lee, Jungwoo +2 more
openaire +3 more sources
Three‑dimensional culture of tumor cells (Review)
Oncology LettersWhile conventional two-dimensional (2D) cell cultures and animal models have been cornerstone technologies in cancer research, they possess limitations in replicating human tumor pathophysiology. Notably, 2D models fail to capture key tissue-level architecture and cell-cell interactions, whereas animal models are often constrained by species-specific ...
Du, Shiyao +5 more
openaire +3 more sources
Three-dimensional human airway epithelial cell cultures [PDF]
Journal of Cystic Fibrosis, 2004 An epithelial airway-derived 3-D cell culture model is described. The long lifetime of this model, compared to monolayer cultures of primary cells, allows many experiments with material from one single patient to be performed.
Ulrich, M., Döring, G.
openaire +2 more sources
Drug discovery approaches utilizing three-dimensional cell culture
, 2016 Historically, two-dimensional (2D) cell culture has been the preferred method of producing disease models in vitro. Recently, there has been a move away from 2D culture in favor of generating three-dimensional (3D) multicellular structures, which are ...
Davies, Anthony +7 more
core +1 more source
Applied Sciences, 2023 The characteristics of 3-dimensional (3D) cultured periodontal ligament stem cells derived from permanent teeth (pPDLSCs) and supernumerary teeth (sPDLSCs) were compared and evaluated in this study.
Heejin Kim +7 more
doaj +1 more source
Three-dimensional cell culture and tissue engineering in a T-CUP (tissue culture under perfusion) [PDF]
, 2007 The aim of this study was to develop and validate a simple and compact bioreactor system for perfusion cell seeding and culture through 3-dimensional porous scaffolds.
Früh, Jennifer-Annika +5 more
core
Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids
Pediatric Blood &Cancer, EarlyView.ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz +12 more
wiley +1 more source
PuraMatrix hydrogel enhances the expression of motor neuron progenitor marker and improves adhesion and proliferation of motor neuron-like cells [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Cell therapy has provided clinical applications to the treatment of motor neuron diseases. The current obstacle in stem cell therapy is to direct differentiation of stem cells into neurons in the neurodegenerative disorders.
Marzieh Darvishi +7 more
doaj +1 more source